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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPI1

Z-value: 0.92

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Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
SPI1
ENSG00000066336.7 Spi-1 proto-oncogene

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_38171681 2.30 ENST00000225474.2
ENST00000331769.2
ENST00000394148.3
ENST00000577675.1
CSF3
colony stimulating factor 3 (granulocyte)
chr17_+_38171614 1.63 ENST00000583218.1
ENST00000394149.3
CSF3
colony stimulating factor 3 (granulocyte)
chr17_+_67590125 1.60 ENST00000591334.1
AC003051.1
AC003051.1
chr2_+_228678550 1.31 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr5_+_159895275 1.25 ENST00000517927.1
MIR146A
microRNA 146a
chr15_-_80263506 1.17 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_+_31543334 0.90 ENST00000449264.2
TNF
tumor necrosis factor
chr6_+_31895467 0.66 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr1_-_114429997 0.66 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr11_+_18154059 0.65 ENST00000531264.1
MRGPRX3
MAS-related GPR, member X3
chr6_+_26156551 0.65 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr6_+_31895480 0.60 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
C2
CFB
complement component 2
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr5_-_150460914 0.54 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr11_-_102826434 0.52 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr6_+_144980954 0.50 ENST00000367525.3
UTRN
utrophin
chr1_+_153330322 0.48 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr22_-_30642728 0.48 ENST00000403987.3
LIF
leukemia inhibitory factor
chr1_-_183560011 0.45 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr5_+_35856951 0.45 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr8_-_42065075 0.44 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
PLAT
plasminogen activator, tissue
chr11_+_102188272 0.41 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr6_-_11382478 0.41 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr8_-_42065187 0.40 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT
plasminogen activator, tissue
chr10_-_75532373 0.39 ENST00000595757.1
AC022400.2
Uncharacterized protein; cDNA FLJ44715 fis, clone BRACE3021430
chr17_+_45908974 0.38 ENST00000269025.4
LRRC46
leucine rich repeat containing 46
chr14_-_69445793 0.38 ENST00000538545.2
ENST00000394419.4
ACTN1
actinin, alpha 1
chr16_+_4845379 0.38 ENST00000588606.1
ENST00000586005.1
SMIM22
small integral membrane protein 22
chr8_-_82395461 0.37 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr11_+_102188224 0.37 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr7_+_105172612 0.37 ENST00000493041.1
RINT1
RAD50 interactor 1
chr8_+_61592073 0.36 ENST00000526846.1
CHD7
chromodomain helicase DNA binding protein 7
chr11_-_102714534 0.36 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr2_+_138721850 0.36 ENST00000329366.4
ENST00000280097.3
HNMT
histamine N-methyltransferase
chr2_-_153573965 0.35 ENST00000448428.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr1_-_235098935 0.35 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr17_-_38859996 0.34 ENST00000264651.2
KRT24
keratin 24
chr1_+_152881014 0.34 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr3_+_119013185 0.34 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr6_-_34524049 0.33 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr14_-_69445968 0.33 ENST00000438964.2
ACTN1
actinin, alpha 1
chr3_+_142838091 0.32 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr17_+_44668387 0.32 ENST00000576040.1
NSF
N-ethylmaleimide-sensitive factor
chr9_+_108424738 0.32 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr17_-_1463095 0.31 ENST00000575895.1
ENST00000573056.1
PITPNA
phosphatidylinositol transfer protein, alpha
chr11_-_3862059 0.31 ENST00000396978.1
RHOG
ras homolog family member G
chr1_-_183559693 0.30 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
NCF2
neutrophil cytosolic factor 2
chr17_-_40134339 0.30 ENST00000587727.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr6_-_41908428 0.30 ENST00000505064.1
CCND3
cyclin D3
chr1_+_152943122 0.29 ENST00000328051.2
SPRR4
small proline-rich protein 4
chr19_+_6772710 0.29 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
VAV1
vav 1 guanine nucleotide exchange factor
chr17_+_6918064 0.28 ENST00000546760.1
ENST00000552402.1
C17orf49
chromosome 17 open reading frame 49
chr18_-_72264805 0.28 ENST00000577806.1
LINC00909
long intergenic non-protein coding RNA 909
chr12_+_96588143 0.28 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr6_+_139349903 0.28 ENST00000461027.1
ABRACL
ABRA C-terminal like
chr17_-_48277552 0.28 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr14_-_69446034 0.28 ENST00000193403.6
ACTN1
actinin, alpha 1
chr1_-_159880159 0.28 ENST00000599780.1
AL590560.1
HCG1995379; Uncharacterized protein
chr6_-_32811771 0.27 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr17_-_4710288 0.27 ENST00000571067.1
RP11-81A22.5
RP11-81A22.5
chr8_+_124194875 0.27 ENST00000522648.1
ENST00000276699.6
FAM83A
family with sequence similarity 83, member A
chr17_+_6918093 0.26 ENST00000439424.2
C17orf49
chromosome 17 open reading frame 49
chr6_-_34524093 0.26 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr8_-_25281747 0.26 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr3_+_9774164 0.26 ENST00000426583.1
BRPF1
bromodomain and PHD finger containing, 1
chr11_-_64815333 0.25 ENST00000533842.1
ENST00000532802.1
ENST00000530139.1
ENST00000526516.1
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr4_+_103422499 0.25 ENST00000511926.1
ENST00000507079.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_-_32160622 0.25 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr2_+_37571717 0.25 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr17_+_7461580 0.24 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_+_12391685 0.24 ENST00000378845.1
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr4_-_40516560 0.24 ENST00000513473.1
RBM47
RNA binding motif protein 47
chr15_+_90544532 0.24 ENST00000268154.4
ZNF710
zinc finger protein 710
chr9_+_134001455 0.24 ENST00000531584.1
NUP214
nucleoporin 214kDa
chr2_-_96811170 0.23 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr16_-_30125177 0.23 ENST00000406256.3
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_+_152214098 0.23 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_5569588 0.23 ENST00000417101.1
ACTB
actin, beta
chr9_-_139268068 0.23 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr4_-_77819002 0.23 ENST00000334306.2
SOWAHB
sosondowah ankyrin repeat domain family member B
chr20_+_31823792 0.23 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPIFA1
BPI fold containing family A, member 1
chr19_+_15218180 0.23 ENST00000342784.2
ENST00000597977.1
ENST00000600440.1
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr6_-_43595039 0.23 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr11_-_6502534 0.22 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
ARFIP2
ADP-ribosylation factor interacting protein 2
chr6_+_30951487 0.22 ENST00000486149.2
ENST00000376296.3
MUC21
mucin 21, cell surface associated
chr1_-_52520828 0.22 ENST00000610127.1
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr18_+_22040593 0.22 ENST00000256906.4
HRH4
histamine receptor H4
chr12_-_92539614 0.22 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr9_-_134145880 0.21 ENST00000372269.3
ENST00000464831.1
FAM78A
family with sequence similarity 78, member A
chr19_-_12792585 0.21 ENST00000351660.5
DHPS
deoxyhypusine synthase
chr16_+_2732476 0.21 ENST00000301738.4
ENST00000564195.1
KCTD5
potassium channel tetramerization domain containing 5
chr17_+_41561317 0.21 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chrX_-_55020511 0.21 ENST00000375006.3
ENST00000374992.2
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_-_58343319 0.21 ENST00000395074.2
LPXN
leupaxin
chr3_-_121379739 0.21 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_156786634 0.21 ENST00000392306.2
ENST00000368199.3
SH2D2A
SH2 domain containing 2A
chr1_-_161039647 0.21 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr7_-_27135591 0.21 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr20_+_3767547 0.20 ENST00000344256.6
ENST00000379598.5
CDC25B
cell division cycle 25B
chr17_-_1029052 0.20 ENST00000574437.1
ABR
active BCR-related
chr10_-_75351088 0.20 ENST00000451492.1
ENST00000413442.1
USP54
ubiquitin specific peptidase 54
chr20_+_2633269 0.20 ENST00000445139.1
NOP56
NOP56 ribonucleoprotein
chr3_+_47324424 0.20 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
KLHL18
kelch-like family member 18
chr15_-_64386120 0.20 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr6_+_30689350 0.20 ENST00000330914.3
TUBB
tubulin, beta class I
chr10_-_75676400 0.20 ENST00000412307.2
C10orf55
chromosome 10 open reading frame 55
chr7_+_114055052 0.20 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr15_-_40398812 0.20 ENST00000561360.1
BMF
Bcl2 modifying factor
chr11_-_6502580 0.20 ENST00000423813.2
ENST00000396777.3
ARFIP2
ADP-ribosylation factor interacting protein 2
chr21_+_17909594 0.20 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_-_982198 0.19 ENST00000571945.1
ENST00000536794.2
ABR
active BCR-related
chr6_+_33589161 0.19 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr4_+_103423055 0.19 ENST00000505458.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_-_161695042 0.19 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr19_-_6481776 0.19 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr19_+_45251804 0.19 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chrX_+_154114635 0.19 ENST00000369446.2
F8A1
coagulation factor VIII-associated 1
chr6_+_30689401 0.19 ENST00000396389.1
ENST00000396384.1
TUBB
tubulin, beta class I
chr1_-_150738261 0.19 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr8_-_28965684 0.19 ENST00000523130.1
KIF13B
kinesin family member 13B
chrX_-_19689106 0.19 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr2_+_219262948 0.19 ENST00000443891.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr7_+_106505696 0.19 ENST00000440650.2
ENST00000496166.1
ENST00000473541.1
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr6_-_161695074 0.19 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr1_-_161039753 0.18 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr8_+_99076509 0.18 ENST00000318528.3
C8orf47
chromosome 8 open reading frame 47
chr17_+_43299241 0.18 ENST00000328118.3
FMNL1
formin-like 1
chr17_+_6918354 0.18 ENST00000552775.1
C17orf49
chromosome 17 open reading frame 49
chr2_+_198669365 0.18 ENST00000428675.1
PLCL1
phospholipase C-like 1
chr5_-_40835303 0.18 ENST00000509877.1
ENST00000508493.1
ENST00000274242.5
RPL37
ribosomal protein L37
chr4_+_81256871 0.18 ENST00000358105.3
ENST00000508675.1
C4orf22
chromosome 4 open reading frame 22
chr1_-_235098861 0.18 ENST00000458044.1
RP11-443B7.1
RP11-443B7.1
chr7_+_106505912 0.18 ENST00000359195.3
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr15_+_75074915 0.18 ENST00000567123.1
ENST00000569462.1
CSK
c-src tyrosine kinase
chr16_-_28506840 0.18 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_-_159924006 0.18 ENST00000368092.3
ENST00000368093.3
SLAMF9
SLAM family member 9
chr15_+_90744533 0.18 ENST00000411539.2
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr1_-_155947951 0.18 ENST00000313695.7
ENST00000497907.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_-_43833628 0.18 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr7_+_157129660 0.18 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr6_-_167040731 0.18 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr16_+_69373323 0.17 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr8_+_56792355 0.17 ENST00000519728.1
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr15_+_75074410 0.17 ENST00000439220.2
CSK
c-src tyrosine kinase
chr20_+_5731083 0.17 ENST00000445603.1
ENST00000442185.1
C20orf196
chromosome 20 open reading frame 196
chr1_-_205912577 0.17 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr17_-_6917755 0.17 ENST00000593646.1
AC040977.1
Uncharacterized protein
chr2_+_169659121 0.17 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
NOSTRIN
nitric oxide synthase trafficking
chr12_+_96588368 0.17 ENST00000547860.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr7_-_45957011 0.17 ENST00000417621.1
IGFBP3
insulin-like growth factor binding protein 3
chr17_-_7760457 0.17 ENST00000576384.1
LSMD1
LSM domain containing 1
chr8_+_24151553 0.17 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr17_-_18907463 0.17 ENST00000585154.2
ENST00000345041.4
FAM83G
family with sequence similarity 83, member G
chr17_-_40913029 0.17 ENST00000592195.1
ENST00000592670.1
ENST00000587694.1
ENST00000591082.1
RAMP2-AS1
RAMP2 antisense RNA 1
chr11_-_8739383 0.17 ENST00000531060.1
ST5
suppression of tumorigenicity 5
chr7_-_45956856 0.17 ENST00000428530.1
IGFBP3
insulin-like growth factor binding protein 3
chr22_+_38004723 0.17 ENST00000381756.5
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr8_+_56792377 0.17 ENST00000520220.2
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr16_-_279405 0.17 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7L
LUC7-like (S. cerevisiae)
chr1_+_179851893 0.17 ENST00000531630.2
TOR1AIP1
torsin A interacting protein 1
chr4_+_103422471 0.17 ENST00000226574.4
ENST00000394820.4
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_8201091 0.17 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr16_-_66968055 0.17 ENST00000568572.1
FAM96B
family with sequence similarity 96, member B
chr11_-_47270341 0.17 ENST00000529444.1
ENST00000530453.1
ENST00000537863.1
ENST00000529788.1
ENST00000444355.2
ENST00000527256.1
ENST00000529663.1
ENST00000256997.3
ACP2
acid phosphatase 2, lysosomal
chr3_-_16555150 0.17 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr15_+_77713299 0.17 ENST00000559099.1
HMG20A
high mobility group 20A
chr2_+_68962014 0.16 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr15_-_64385981 0.16 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr17_+_7462103 0.16 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_-_98031155 0.16 ENST00000495266.1
BLNK
B-cell linker
chr7_-_45018686 0.16 ENST00000258787.7
MYO1G
myosin IG
chr12_-_123201337 0.16 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr6_-_159466136 0.16 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr11_-_102401469 0.16 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr6_-_154751629 0.16 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr5_-_43412418 0.16 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr1_-_212588157 0.16 ENST00000261455.4
ENST00000535273.1
TMEM206
transmembrane protein 206
chr16_-_66968265 0.16 ENST00000567511.1
ENST00000422424.2
FAM96B
family with sequence similarity 96, member B
chr11_+_131781290 0.16 ENST00000425719.2
ENST00000374784.1
NTM
neurotrimin
chr1_-_207095324 0.16 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chrX_-_100662881 0.16 ENST00000218516.3
GLA
galactosidase, alpha
chr4_+_2626988 0.16 ENST00000509050.1
FAM193A
family with sequence similarity 193, member A
chr11_+_64794875 0.16 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
SNX15
sorting nexin 15
chr21_+_33671160 0.16 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr6_-_155635583 0.16 ENST00000367166.4
TFB1M
transcription factor B1, mitochondrial
chr1_-_161039456 0.16 ENST00000368016.3
ARHGAP30
Rho GTPase activating protein 30
chr17_+_7255208 0.16 ENST00000333751.3
KCTD11
potassium channel tetramerization domain containing 11
chr14_+_102276192 0.16 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_+_50388126 0.16 ENST00000425346.1
ENST00000424512.1
ENST00000232508.5
ENST00000418577.1
ENST00000606589.1
CYB561D2
XXcos-LUCA11.5
cytochrome b561 family, member D2
Uncharacterized protein
chr5_-_131826457 0.16 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr3_-_161089289 0.16 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr17_-_40913275 0.16 ENST00000589716.1
ENST00000360166.3
RAMP2-AS1
RAMP2 antisense RNA 1
chr1_+_41174988 0.15 ENST00000372652.1
NFYC
nuclear transcription factor Y, gamma
chr5_+_139505520 0.15 ENST00000333305.3
IGIP
IgA-inducing protein
chr11_+_120081475 0.15 ENST00000328965.4
OAF
OAF homolog (Drosophila)
chr8_+_124194752 0.15 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr3_-_192445289 0.15 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr6_-_33290580 0.15 ENST00000446511.1
ENST00000446403.1
ENST00000414083.2
ENST00000266000.6
ENST00000374542.5
DAXX
death-domain associated protein
chr17_+_18218587 0.15 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr16_-_67693846 0.15 ENST00000602850.1
ACD
adrenocortical dysplasia homolog (mouse)
chr22_-_31328881 0.15 ENST00000445980.1
MORC2
MORC family CW-type zinc finger 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 0.9 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.3 3.9 GO:0030223 neutrophil differentiation(GO:0030223)
0.2 0.6 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.2 0.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 0.5 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.4 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.4 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.3 GO:0070666 regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.5 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.6 GO:0060481 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.1 0.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.5 GO:0046203 spermidine catabolic process(GO:0046203)
0.1 0.4 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.1 0.4 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.3 GO:1990637 response to prolactin(GO:1990637)
0.1 0.5 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.3 GO:0044691 tooth eruption(GO:0044691)
0.1 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.3 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) peptidyl-glutamine modification(GO:0018199) isopeptide cross-linking(GO:0018262)
0.1 0.7 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.2 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.1 0.2 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.2 GO:1900191 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.1 0.9 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.1 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.5 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.1 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 0.2 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.1 0.2 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.4 GO:0030578 PML body organization(GO:0030578)
0.0 0.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.6 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.0 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.3 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 1.1 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.0 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.3 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.0 1.2 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.1 GO:0098751 megakaryocyte development(GO:0035855) bone cell development(GO:0098751)
0.0 0.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:1904457 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.0 0.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.2 GO:0016139 glycoside catabolic process(GO:0016139) glycosylceramide catabolic process(GO:0046477)
0.0 0.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.4 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.2 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.1 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.1 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 1.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0033590 response to cobalamin(GO:0033590) response to erythropoietin(GO:0036017) cellular response to erythropoietin(GO:0036018) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.1 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.0 0.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.2 GO:0021603 cranial nerve formation(GO:0021603)
0.0 0.1 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.5 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.4 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 0.4 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:0060178 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
0.0 0.1 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0061354 chemoattraction of serotonergic neuron axon(GO:0036517) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.0 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.0 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.2 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.1 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.2 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.4 GO:0071801 regulation of podosome assembly(GO:0071801)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.0 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.2 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.3 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0070092 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0 0.1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.0 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.0 GO:0008355 olfactory learning(GO:0008355)
0.0 0.1 GO:1904874 positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.0 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.0 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.0 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.1 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0046874 quinolinate metabolic process(GO:0046874) pyridine-containing compound catabolic process(GO:0072526)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 0.3 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.9 GO:0032010 phagolysosome(GO:0032010)
0.1 0.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.3 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.7 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.1 GO:0005916 fascia adherens(GO:0005916)
0.1 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.1 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.3 GO:0071817 MMXD complex(GO:0071817)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.0 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.1 GO:0043257 laminin-8 complex(GO:0043257)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.0 GO:0042022 interleukin-12 receptor complex(GO:0042022)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0034709 methylosome(GO:0034709)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 0.5 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.2 0.5 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.2 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.4 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.3 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.1 0.6 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.3 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.1 GO:0001846 opsonin binding(GO:0001846)
0.1 1.2 GO:0051400 BH domain binding(GO:0051400)
0.1 0.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.0 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.4 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 1.3 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.2 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 2.8 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0005549 odorant binding(GO:0005549)
0.0 0.0 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.2 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.4 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.0 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0050321 tau-protein kinase activity(GO:0050321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 6.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 ST ADRENERGIC Adrenergic Pathway
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 0.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets