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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPDEF

Z-value: 0.96

Motif logo

Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524049_34524091-0.971.2e-03Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_105212297 0.74 ENST00000556623.1
ENST00000555674.1
adenylosuccinate synthase like 1
chr5_+_158690089 0.70 ENST00000296786.6
ubiquitin-like domain containing CTD phosphatase 1
chr4_+_141445333 0.54 ENST00000507667.1
ELMO/CED-12 domain containing 2
chr7_-_77427676 0.49 ENST00000257663.3
transmembrane protein 60
chr4_-_153700864 0.47 ENST00000304337.2
tigger transposable element derived 4
chr14_-_31926623 0.46 ENST00000356180.4
D-tyrosyl-tRNA deacylase 2 (putative)
chr8_-_100025238 0.44 ENST00000521696.1
RP11-410L14.2
chr17_-_56065540 0.44 ENST00000583932.1
vascular endothelial zinc finger 1
chr18_-_19180681 0.43 ENST00000269214.5
establishment of sister chromatid cohesion N-acetyltransferase 1
chr14_-_67826538 0.41 ENST00000553687.1
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr4_+_48833312 0.41 ENST00000508293.1
ENST00000513391.2
OCIA domain containing 1
chr15_-_65282274 0.36 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_+_84629976 0.35 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_71751715 0.34 ENST00000535947.1
nuclear mitotic apparatus protein 1
chr2_-_63815628 0.34 ENST00000409562.3
WD repeat containing planar cell polarity effector
chr4_+_166128735 0.34 ENST00000226725.6
kelch-like family member 2
chr1_+_67395922 0.34 ENST00000401042.3
ENST00000355356.3
mesoderm induction early response 1, transcriptional regulator
chr15_-_65282232 0.33 ENST00000416889.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_+_84630053 0.33 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_119806085 0.33 ENST00000355624.3
RAB11 family interacting protein 2 (class I)
chr1_+_193028552 0.33 ENST00000400968.2
ENST00000432079.1
TROVE domain family, member 2
chr7_-_38948774 0.33 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr14_-_31926595 0.32 ENST00000547378.1
Uncharacterized protein
chr14_+_60716276 0.32 ENST00000528241.2
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr17_+_65714018 0.32 ENST00000581106.1
ENST00000535137.1
nucleolar protein 11
chr9_-_72374848 0.32 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
protein prenyltransferase alpha subunit repeat containing 1
chr17_+_65713925 0.31 ENST00000253247.4
nucleolar protein 11
chr14_-_64010006 0.31 ENST00000555899.1
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr15_-_59949667 0.31 ENST00000396061.1
general transcription factor IIA, 2, 12kDa
chr12_+_102513950 0.31 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chr3_+_32023232 0.31 ENST00000360311.4
zinc finger protein 860
chr12_-_57914275 0.30 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DNA-damage-inducible transcript 3
chr7_-_91875109 0.30 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1, ankyrin repeat containing
chr7_+_77428066 0.30 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr15_-_64648273 0.29 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
casein kinase 1, gamma 1
chr8_-_124665190 0.29 ENST00000325995.7
kelch-like family member 38
chr5_-_114961858 0.29 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr4_+_48833183 0.28 ENST00000503016.1
OCIA domain containing 1
chr10_-_14996070 0.28 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DNA cross-link repair 1C
chr12_+_102514019 0.27 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARP1 binding protein
chr12_+_29302119 0.27 ENST00000536681.3
fatty acyl CoA reductase 2
chr7_+_77428149 0.27 ENST00000415251.2
ENST00000275575.7
putative homeodomain transcription factor 2
chr8_+_15397732 0.27 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
tumor suppressor candidate 3
chr3_-_139108463 0.26 ENST00000512242.1
coatomer protein complex, subunit beta 2 (beta prime)
chr2_+_198380289 0.26 ENST00000233892.4
ENST00000409916.1
MOB family member 4, phocein
chr6_+_134274354 0.26 ENST00000367869.1
TBP-like 1
chr1_+_235492300 0.25 ENST00000476121.1
ENST00000497327.1
geranylgeranyl diphosphate synthase 1
chr2_+_162016827 0.25 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TRAF family member-associated NFKB activator
chr15_+_80987617 0.25 ENST00000258884.4
ENST00000558464.1
abhydrolase domain containing 17C
chr2_+_63816126 0.25 ENST00000454035.1
malate dehydrogenase 1, NAD (soluble)
chr19_-_45004556 0.25 ENST00000587047.1
ENST00000391956.4
ENST00000221327.4
ENST00000586637.1
ENST00000591064.1
ENST00000592529.1
zinc finger protein 180
chr8_-_77912431 0.25 ENST00000357039.4
ENST00000522527.1
peroxisomal biogenesis factor 2
chr14_-_31926701 0.24 ENST00000310850.4
D-tyrosyl-tRNA deacylase 2 (putative)
chr12_+_29302023 0.24 ENST00000551451.1
fatty acyl CoA reductase 2
chr4_+_39640787 0.24 ENST00000532680.1
RP11-539G18.2
chr7_-_91875358 0.24 ENST00000458177.1
ENST00000394507.1
ENST00000340022.2
ENST00000444960.1
KRIT1, ankyrin repeat containing
chr1_-_193028426 0.24 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
ubiquitin carboxyl-terminal hydrolase L5
chr13_+_25670268 0.24 ENST00000281589.3
poly(A) binding protein, cytoplasmic 3
chr1_+_170501270 0.23 ENST00000367763.3
ENST00000367762.1
golgin, RAB6-interacting
chr4_-_83812157 0.23 ENST00000513323.1
SEC31 homolog A (S. cerevisiae)
chr14_+_60716159 0.23 ENST00000325658.3
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_+_144106063 0.23 ENST00000510377.1
ubiquitin specific peptidase 38
chr14_-_69263043 0.23 ENST00000408913.2
ZFP36 ring finger protein-like 1
chr1_-_193028621 0.22 ENST00000367455.4
ENST00000367454.1
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_48833119 0.22 ENST00000444354.2
ENST00000509963.1
ENST00000509246.1
OCIA domain containing 1
chr2_-_54014127 0.22 ENST00000394717.2
GPR75-ASB3 readthrough
chrX_-_131352152 0.22 ENST00000342983.2
RAP2C, member of RAS oncogene family
chr5_+_110074685 0.22 ENST00000355943.3
ENST00000447245.2
solute carrier family 25, member 46
chr8_-_56986768 0.22 ENST00000523936.1
ribosomal protein S20
chr18_+_48556470 0.21 ENST00000589076.1
ENST00000590061.1
ENST00000591914.1
ENST00000342988.3
SMAD family member 4
chr8_-_130951940 0.21 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
family with sequence similarity 49, member B
chr20_-_34287220 0.21 ENST00000306750.3
NFS1 cysteine desulfurase
chr6_-_143832793 0.21 ENST00000438118.2
fucosidase, alpha-L- 2, plasma
chr19_+_38880695 0.21 ENST00000587947.1
ENST00000338502.4
sprouty-related, EVH1 domain containing 3
chr12_+_49961990 0.21 ENST00000551063.1
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr14_-_64010046 0.20 ENST00000337537.3
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_+_27805880 0.20 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
zinc finger protein 512
chr9_+_36190853 0.20 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
clathrin, light chain A
chr18_+_11851383 0.20 ENST00000526991.2
charged multivesicular body protein 1B
chr2_+_101618691 0.20 ENST00000409000.1
ENST00000409028.4
ENST00000409320.3
ENST00000409733.1
ENST00000409650.1
ENST00000409038.1
ribosomal protein L31
chr3_-_133380731 0.20 ENST00000260810.5
topoisomerase (DNA) II binding protein 1
chr10_-_15902449 0.19 ENST00000277632.3
family with sequence similarity 188, member A
chr16_-_25122785 0.19 ENST00000563962.1
ENST00000569920.1
RP11-449H11.1
chr7_-_135662056 0.19 ENST00000393085.3
ENST00000435723.1
myotrophin
chr19_-_53696587 0.19 ENST00000396424.3
ENST00000600412.1
zinc finger protein 665
chr9_+_36190905 0.19 ENST00000345519.5
ENST00000470744.1
ENST00000242285.6
ENST00000466396.1
ENST00000396603.2
clathrin, light chain A
chr4_+_48833015 0.19 ENST00000509122.1
ENST00000509664.1
ENST00000505922.2
ENST00000514981.1
OCIA domain containing 1
chr12_-_64616019 0.19 ENST00000311915.8
ENST00000398055.3
ENST00000544871.1
chromosome 12 open reading frame 66
chr1_+_235491714 0.19 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
geranylgeranyl diphosphate synthase 1
chr17_-_33905521 0.19 ENST00000225873.4
peroxisomal biogenesis factor 12
chr2_+_217363793 0.19 ENST00000456586.1
ENST00000598925.1
ENST00000427280.2
ribosomal protein L37a
chr15_-_59949693 0.19 ENST00000396063.1
ENST00000396064.3
ENST00000484743.1
ENST00000559706.1
ENST00000396060.2
general transcription factor IIA, 2, 12kDa
chr7_+_93551011 0.19 ENST00000248564.5
guanine nucleotide binding protein (G protein), gamma 11
chr2_+_162016804 0.18 ENST00000392749.2
ENST00000440506.1
TRAF family member-associated NFKB activator
chr11_-_118122996 0.18 ENST00000525386.1
ENST00000527472.1
ENST00000278949.4
myelin protein zero-like 3
chr1_+_193028717 0.18 ENST00000415442.2
ENST00000506303.1
TROVE domain family, member 2
chr17_-_7108436 0.18 ENST00000493294.1
discs, large homolog 4 (Drosophila)
chr1_-_169337176 0.18 ENST00000472647.1
ENST00000367811.3
NME/NM23 family member 7
chr14_+_60715928 0.18 ENST00000395076.4
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr8_-_101964738 0.18 ENST00000523938.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_48833160 0.18 ENST00000506801.1
OCIA domain containing 1
chr14_+_67826709 0.17 ENST00000256383.4
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_63816087 0.17 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
malate dehydrogenase 1, NAD (soluble)
chr3_-_37217736 0.17 ENST00000438374.1
leucine rich repeat (in FLII) interacting protein 2
chr2_-_54014055 0.17 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3 readthrough
chr1_+_22351977 0.17 ENST00000420503.1
ENST00000416769.1
ENST00000404210.2
long intergenic non-protein coding RNA 339
chr5_+_76326187 0.17 ENST00000312916.7
ENST00000506806.1
angiogenic factor with G patch and FHA domains 1
chr3_+_197464046 0.17 ENST00000428738.1
forty-two-three domain containing 1
chr2_+_162016916 0.16 ENST00000405852.1
TRAF family member-associated NFKB activator
chr14_-_69864993 0.16 ENST00000555373.1
enhancer of rudimentary homolog (Drosophila)
chr2_+_37311588 0.16 ENST00000409774.1
ENST00000608836.1
G patch domain containing 11
chr2_+_39103103 0.16 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN repeat containing 2
chr20_+_60962143 0.16 ENST00000343986.4
ribosomal protein S21
chr4_+_48833234 0.16 ENST00000510824.1
ENST00000425583.2
OCIA domain containing 1
chr11_-_119993734 0.16 ENST00000533302.1
tripartite motif containing 29
chr14_+_21566980 0.16 ENST00000418511.2
ENST00000554329.2
transmembrane protein 253
chr1_+_84630574 0.16 ENST00000413538.1
ENST00000417530.1
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_99613195 0.15 ENST00000324306.6
zinc finger with KRAB and SCAN domains 1
chr12_+_106751436 0.15 ENST00000228347.4
polymerase (RNA) III (DNA directed) polypeptide B
chr4_-_44728559 0.15 ENST00000509756.1
ENST00000507917.1
ENST00000295448.3
glucosamine-6-phosphate deaminase 2
chr12_+_50135351 0.15 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
transmembrane BAX inhibitor motif containing 6
chr8_-_56987061 0.15 ENST00000009589.3
ENST00000524349.1
ENST00000519606.1
ENST00000519807.1
ENST00000521262.1
ENST00000520627.1
ribosomal protein S20
chr2_+_48667898 0.15 ENST00000281394.4
ENST00000294952.8
protein phosphatase 1, regulatory subunit 21
chr15_-_65809581 0.15 ENST00000341861.5
dipeptidyl-peptidase 8
chr21_-_46221684 0.15 ENST00000330942.5
ubiquitin-conjugating enzyme E2G 2
chr4_+_144106080 0.15 ENST00000307017.4
ubiquitin specific peptidase 38
chr18_+_21032781 0.15 ENST00000339486.3
RIO kinase 3
chr17_-_56082455 0.15 ENST00000578794.1
Uncharacterized protein
chr3_-_156272924 0.15 ENST00000467789.1
ENST00000265044.2
signal sequence receptor, gamma (translocon-associated protein gamma)
chr4_+_41992489 0.14 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr14_+_24701870 0.14 ENST00000561035.1
ENST00000559409.1
ENST00000558865.1
ENST00000558279.1
guanosine monophosphate reductase 2
chr7_+_114562172 0.14 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr3_+_29322437 0.14 ENST00000434693.2
RNA binding motif, single stranded interacting protein 3
chr6_-_150039249 0.14 ENST00000543571.1
large tumor suppressor kinase 1
chr8_+_8860314 0.14 ENST00000250263.7
ENST00000519292.1
exoribonuclease 1
chr2_+_27805971 0.14 ENST00000413371.2
zinc finger protein 512
chrX_-_122866874 0.14 ENST00000245838.8
ENST00000355725.4
THO complex 2
chr2_+_65454926 0.13 ENST00000542850.1
ENST00000377982.4
ARP2 actin-related protein 2 homolog (yeast)
chr12_-_69080590 0.13 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2
chr8_-_101964832 0.13 ENST00000523131.1
ENST00000418997.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_159593418 0.13 ENST00000507475.1
ENST00000307738.5
electron-transferring-flavoprotein dehydrogenase
chr6_-_150039170 0.13 ENST00000458696.2
ENST00000392273.3
large tumor suppressor kinase 1
chr2_+_47596634 0.13 ENST00000419334.1
epithelial cell adhesion molecule
chr7_+_99613212 0.13 ENST00000426572.1
ENST00000535170.1
zinc finger with KRAB and SCAN domains 1
chr1_-_235324772 0.13 ENST00000408888.3
RNA binding motif protein 34
chr12_+_69080734 0.13 ENST00000378905.2
nucleoporin 107kDa
chr1_+_65886244 0.13 ENST00000344610.8
leptin receptor
chr14_-_24615523 0.13 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr18_+_21033239 0.13 ENST00000581585.1
ENST00000577501.1
RIO kinase 3
chr1_+_84630645 0.13 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_19321281 0.12 ENST00000261537.6
mindbomb E3 ubiquitin protein ligase 1
chr2_+_65454863 0.12 ENST00000260641.5
ARP2 actin-related protein 2 homolog (yeast)
chr3_-_37218023 0.12 ENST00000416425.1
leucine rich repeat (in FLII) interacting protein 2
chr12_+_50135327 0.12 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
transmembrane BAX inhibitor motif containing 6
chr5_+_93954039 0.12 ENST00000265140.5
ankyrin repeat domain 32
chr11_-_61197406 0.12 ENST00000541963.1
ENST00000477890.2
cleavage and polyadenylation specific factor 7, 59kDa
chr14_+_24701819 0.11 ENST00000560139.1
ENST00000559910.1
guanosine monophosphate reductase 2
chr12_-_120663792 0.11 ENST00000546532.1
ENST00000548912.1
paxillin
chr2_+_37311645 0.11 ENST00000281932.5
G patch domain containing 11
chr15_-_44092295 0.11 ENST00000249714.3
ENST00000299969.6
ENST00000319327.6
serine incorporator 4
chr10_+_5726764 0.11 ENST00000328090.5
ENST00000496681.1
family with sequence similarity 208, member B
chr1_+_24829384 0.11 ENST00000374395.4
ENST00000436717.2
RCAN family member 3
chr18_-_55288973 0.11 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
asparaginyl-tRNA synthetase
chr17_-_47755436 0.10 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr3_-_69101461 0.10 ENST00000543976.1
TATA element modulatory factor 1
chr16_-_70557430 0.10 ENST00000393612.4
ENST00000564653.1
ENST00000323786.5
component of oligomeric golgi complex 4
chr12_+_132434439 0.10 ENST00000333577.4
ENST00000389561.2
ENST00000389562.2
ENST00000332482.4
ENST00000330386.6
E1A binding protein p400
chr19_-_8579030 0.10 ENST00000255616.8
ENST00000393927.4
zinc finger protein 414
chr5_-_114961673 0.10 ENST00000333314.3
TMED7-TICAM2 readthrough
chr6_+_7541808 0.10 ENST00000379802.3
desmoplakin
chr1_+_213224572 0.10 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr1_+_169337172 0.10 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
basic leucine zipper nuclear factor 1
chr11_+_36616355 0.09 ENST00000532470.2
chromosome 11 open reading frame 74
chr22_-_41215291 0.09 ENST00000542412.1
ENST00000544408.1
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr11_+_61197508 0.09 ENST00000541135.1
ENST00000301761.2
Uncharacterized protein
succinate dehydrogenase complex assembly factor 2
chr21_-_36421626 0.09 ENST00000300305.3
runt-related transcription factor 1
chr1_-_193028632 0.09 ENST00000421683.1
ubiquitin carboxyl-terminal hydrolase L5
chr6_-_116381918 0.09 ENST00000606080.1
fyn-related kinase
chr10_-_14996017 0.09 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DNA cross-link repair 1C
chr11_-_46142948 0.09 ENST00000257821.4
PHD finger protein 21A
chr8_-_101734170 0.09 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr1_+_43124087 0.09 ENST00000304979.3
ENST00000372550.1
ENST00000440068.1
peptidylprolyl isomerase H (cyclophilin H)
chr4_-_159592996 0.09 ENST00000508457.1
chromosome 4 open reading frame 46
chr19_-_56632592 0.09 ENST00000587279.1
ENST00000270459.3
zinc finger protein 787
chr5_+_31532373 0.09 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
chromosome 5 open reading frame 22
chr11_+_57480046 0.09 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr20_+_49126881 0.09 ENST00000371621.3
ENST00000541713.1
protein tyrosine phosphatase, non-receptor type 1
chr11_-_61129306 0.08 ENST00000544118.1
cytochrome b561 family, member A3
chr14_+_24702073 0.08 ENST00000399440.2
guanosine monophosphate reductase 2
chr6_-_143832820 0.08 ENST00000002165.6
fucosidase, alpha-L- 2, plasma
chr12_+_118814185 0.08 ENST00000543473.1
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr16_-_2318111 0.08 ENST00000301730.8
ENST00000564822.1
RNA binding protein S1, serine-rich domain
chr3_-_69101413 0.08 ENST00000398559.2
TATA element modulatory factor 1
chr15_-_55700457 0.08 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
cell cycle progression 1
chr1_+_169337412 0.08 ENST00000426663.1
basic leucine zipper nuclear factor 1
chr8_-_101965104 0.08 ENST00000437293.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr11_-_57479673 0.08 ENST00000337672.2
ENST00000431606.2
mediator complex subunit 19
chr2_+_187350883 0.08 ENST00000337859.6
zinc finger CCCH-type containing 15
chr11_-_94706705 0.08 ENST00000279839.6
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr12_-_102513843 0.08 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.4 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 1.1 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 0.5 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.3 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 0.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:0006043 glucosamine catabolic process(GO:0006043)
0.1 0.2 GO:0035262 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) gonad morphogenesis(GO:0035262)
0.1 0.3 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.3 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 0.3 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.2 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.1 0.2 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.0 0.3 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0043132 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.2 GO:2000843 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.2 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.3 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.3 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.3 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.6 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.2 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.2 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.3 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.4 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.0 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.4 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.2 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0090383 phagosome acidification(GO:0090383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.4 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0071439 clathrin complex(GO:0071439)
0.0 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.2 0.7 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.4 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.3 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 0.4 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.5 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.4 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.2 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.3 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes