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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SPDEF
Z-value: 0.96
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg19_v2_chr6_-_34524049_34524091 | -0.97 | 1.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_105212297 Show fit | 0.74 |
ENST00000556623.1
ENST00000555674.1 |
adenylosuccinate synthase like 1 |
|
| chr5_+_158690089 Show fit | 0.70 |
ENST00000296786.6
|
ubiquitin-like domain containing CTD phosphatase 1 |
|
| chr4_+_141445333 Show fit | 0.54 |
ENST00000507667.1
|
ELMO/CED-12 domain containing 2 |
|
| chr7_-_77427676 Show fit | 0.49 |
ENST00000257663.3
|
transmembrane protein 60 |
|
| chr4_-_153700864 Show fit | 0.47 |
ENST00000304337.2
|
tigger transposable element derived 4 |
|
| chr14_-_31926623 Show fit | 0.46 |
ENST00000356180.4
|
D-tyrosyl-tRNA deacylase 2 (putative) |
|
| chr8_-_100025238 Show fit | 0.44 |
ENST00000521696.1
|
RP11-410L14.2 |
|
| chr17_-_56065540 Show fit | 0.44 |
ENST00000583932.1
|
vascular endothelial zinc finger 1 |
|
| chr18_-_19180681 Show fit | 0.43 |
ENST00000269214.5
|
establishment of sister chromatid cohesion N-acetyltransferase 1 |
|
| chr14_-_67826538 Show fit | 0.41 |
ENST00000553687.1
|
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 0.7 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.1 | 0.7 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 0.6 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 0.6 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 0.6 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.0 | 0.6 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.1 | 0.5 | GO:0010166 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.0 | 0.5 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 0.5 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.1 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 0.7 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.2 | 0.6 | GO:0034455 | t-UTP complex(GO:0034455) |
| 0.0 | 0.6 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 0.6 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.4 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 0.7 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
| 0.2 | 0.7 | GO:0051500 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.1 | 0.7 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.7 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.6 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.6 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 0.5 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.0 | 0.5 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 0.4 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.0 | 0.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.7 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.5 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.4 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |