ISMARA results: SP3

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SP3

Z-value: 2.15

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Transcription factors associated with SP3

Gene Symbol	Gene ID	Gene Info
SP3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172845.9	Sp3 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP3	hg19_v2_chr2_-_174828892_174828972	-0.10	8.5e-01	Click!

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_144651024 Show fit	3.36	ENST00000524906.1 ENST00000532862.1 ENST00000534459.1	MROH6 Ensembl NCBI GeneCards UniProt NextProt Show fit	maestro heat-like repeat family member 6
chr19_-_4065730 Show fit	3.16	ENST00000601588.1	ZBTB7A Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 7A
chr19_-_2015699 Show fit	2.74	ENST00000255608.4	BTBD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	BTB (POZ) domain containing 2
chr12_+_113012831 Show fit	2.59	ENST00000547686.1 ENST00000543106.2 ENST00000551593.1 ENST00000546426.1 ENST00000551748.1	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)
chr11_+_65686952 Show fit	2.40	ENST00000527119.1	DRAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	DR1-associated protein 1 (negative cofactor 2 alpha)
chr14_+_105559784 Show fit	2.27	ENST00000548104.1	RP11-44N21.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-44N21.1
chr9_+_140317802 Show fit	2.23	ENST00000341349.2 ENST00000392815.2	NOXA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NADPH oxidase activator 1
chr7_+_149411860 Show fit	2.22	ENST00000486744.1	KRBA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	KRAB-A domain containing 1
chr18_+_11981547 Show fit	2.19	ENST00000588927.1	IMPA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol(myo)-1(or 4)-monophosphatase 2
chr2_-_178129551 Show fit	2.19	ENST00000430047.1	NFE2L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear factor, erythroid 2-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	8.4	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.7	6.7	GO:0006021	inositol biosynthetic process(GO:0006021)
0.0	5.9	GO:1902476	chloride transmembrane transport(GO:1902476)
0.2	5.5	GO:0032094	response to food(GO:0032094)
0.4	5.3	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	5.3	GO:0036503	ERAD pathway(GO:0036503)
0.0	5.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.3	4.6	GO:0006228	UTP biosynthetic process(GO:0006228)
0.6	4.5	GO:0030200	heparan sulfate proteoglycan catabolic process(GO:0030200)

Showing 1 to 10 of 1,256 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	12.1	GO:0005796	Golgi lumen(GO:0005796)
0.3	9.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	7.4	GO:0016324	apical plasma membrane(GO:0016324)
0.1	7.0	GO:0005604	basement membrane(GO:0005604)
0.0	6.8	GO:0031901	early endosome membrane(GO:0031901)
0.0	6.7	GO:0055037	recycling endosome(GO:0055037)
0.0	6.7	GO:0030133	transport vesicle(GO:0030133)
0.0	5.9	GO:0005903	brush border(GO:0005903)
0.0	5.2	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Showing 1 to 10 of 380 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.5	GO:0030695	GTPase regulator activity(GO:0030695)
0.0	9.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	7.3	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.2	6.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.3	5.6	GO:0017154	semaphorin receptor activity(GO:0017154)
0.4	5.5	GO:0019826	oxygen sensor activity(GO:0019826)
0.6	5.4	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.2	5.4	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	5.0	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	4.7	GO:0003823	antigen binding(GO:0003823)

Showing 1 to 10 of 705 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	9.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	8.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	6.5	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.1	5.5	PID LKB1 PATHWAY	LKB1 signaling events
0.1	5.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	5.3	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	4.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	4.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	4.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 95 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.4	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	7.1	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.1	6.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	5.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	5.0	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	4.7	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	4.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	4.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	3.7	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	3.7	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters

Showing 1 to 10 of 151 entries

Results for SP3

Z-value: 2.15

Motif logo

Transcription factors associated with SP3

Activity-expression correlation:

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: