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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SP1
Z-value: 2.54
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53774423_53774658 | 0.76 | 8.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_96928516 Show fit | 6.71 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr21_+_37529055 Show fit | 4.37 |
ENST00000270190.4
|
dopey family member 2 |
|
| chr19_-_48673465 Show fit | 4.08 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr8_-_99837856 Show fit | 3.28 |
ENST00000518165.1
ENST00000419617.2 |
serine/threonine kinase 3 |
|
| chr2_+_30369859 Show fit | 3.18 |
ENST00000402003.3
|
yippee-like 5 (Drosophila) |
|
| chr19_+_47760777 Show fit | 2.58 |
ENST00000599398.1
ENST00000595659.1 |
coiled-coil domain containing 9 |
|
| chr2_+_99758161 Show fit | 2.24 |
ENST00000409684.1
|
Uncharacterized protein C2orf15 |
|
| chr1_+_6845578 Show fit | 2.17 |
ENST00000467404.2
ENST00000439411.2 |
calmodulin binding transcription activator 1 |
|
| chr10_-_126849626 Show fit | 2.17 |
ENST00000530884.1
|
C-terminal binding protein 2 |
|
| chr16_-_81129845 Show fit | 2.15 |
ENST00000569885.1
ENST00000566566.1 |
glycine cleavage system protein H (aminomethyl carrier) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.5 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 6.7 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 5.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 5.1 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 4.8 | GO:0007031 | peroxisome organization(GO:0007031) |
| 0.4 | 4.7 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.5 | 4.3 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 4.2 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 4.2 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.5 | 4.1 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 8.0 | GO:1903293 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.1 | 8.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 6.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 6.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 6.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 6.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 5.6 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 5.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 5.0 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 7.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 7.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.5 | 6.6 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 5.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 5.6 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.0 | 5.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 5.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 5.1 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 4.9 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 9.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 4.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 4.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 4.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 3.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 6.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 5.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 5.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 5.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 5.0 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 5.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 4.9 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 4.8 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.1 | 4.7 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |