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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX7

Z-value: 0.50

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.6 SRY-box transcription factor 7
SOX7
ENSG00000258724.1 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg19_v2_chr8_-_10588010_105880300.483.3e-01Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_65235916 0.44 ENST00000579861.1
HELZ
helicase with zinc finger
chr4_+_75174180 0.43 ENST00000413830.1
EPGN
epithelial mitogen
chr21_+_34144411 0.26 ENST00000382375.4
ENST00000453404.1
ENST00000382378.1
ENST00000477513.1
C21orf49
chromosome 21 open reading frame 49
chr1_-_152061537 0.25 ENST00000368806.1
TCHHL1
trichohyalin-like 1
chr15_+_63414760 0.24 ENST00000557972.1
LACTB
lactamase, beta
chr12_-_123728548 0.24 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr1_-_43751230 0.23 ENST00000523677.1
C1orf210
chromosome 1 open reading frame 210
chr1_+_100598742 0.22 ENST00000370139.1
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr8_+_74271144 0.21 ENST00000519134.1
ENST00000518355.1
RP11-434I12.3
RP11-434I12.3
chr3_-_123411191 0.19 ENST00000354792.5
ENST00000508240.1
MYLK
myosin light chain kinase
chr8_-_102803163 0.19 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr4_-_39034542 0.19 ENST00000344606.6
TMEM156
transmembrane protein 156
chr18_+_32820990 0.18 ENST00000601719.1
ENST00000591206.1
ENST00000330501.7
ENST00000261333.6
ENST00000355632.4
ENST00000585800.1
ZNF397
zinc finger protein 397
chr15_+_66585950 0.17 ENST00000525109.1
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr12_-_57443886 0.13 ENST00000300119.3
MYO1A
myosin IA
chr4_-_4544061 0.12 ENST00000507908.1
STX18
syntaxin 18
chr3_+_107318157 0.12 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr2_-_190445499 0.11 ENST00000261024.2
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr6_+_80129989 0.11 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chr6_-_111804905 0.11 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr19_-_38916839 0.11 ENST00000433821.2
ENST00000426920.2
ENST00000587753.1
ENST00000454404.2
ENST00000293062.9
RASGRP4
RAS guanyl releasing protein 4
chr4_+_76995855 0.10 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr6_-_86303833 0.10 ENST00000505648.1
SNX14
sorting nexin 14
chr14_+_60712463 0.10 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr16_-_21442874 0.08 ENST00000534903.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr2_-_88285309 0.07 ENST00000420840.2
RGPD2
RANBP2-like and GRIP domain containing 2
chr1_+_100598691 0.07 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr14_-_102771462 0.07 ENST00000522874.1
MOK
MOK protein kinase
chr16_+_22518495 0.06 ENST00000541154.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr10_-_12084770 0.06 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr9_-_70465758 0.06 ENST00000489273.1
CBWD5
COBW domain containing 5
chr14_+_50291993 0.06 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr10_-_96829246 0.06 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr6_+_150690028 0.06 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr10_-_5046042 0.05 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr10_+_5005445 0.05 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr2_+_87144738 0.05 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr4_-_47983519 0.05 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr5_+_175511859 0.05 ENST00000503724.2
ENST00000253490.4
FAM153B
family with sequence similarity 153, member B
chr1_-_43751276 0.04 ENST00000423420.1
C1orf210
chromosome 1 open reading frame 210
chr15_+_75639372 0.04 ENST00000566313.1
ENST00000568059.1
ENST00000568881.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr14_-_31856397 0.04 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr1_-_54303934 0.04 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr6_+_42531798 0.04 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr6_+_29555683 0.04 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr16_-_28303360 0.03 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr19_-_38916822 0.03 ENST00000586305.1
RASGRP4
RAS guanyl releasing protein 4
chr12_-_90049878 0.03 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr21_-_15918618 0.03 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr13_-_28024681 0.03 ENST00000381116.1
ENST00000381120.3
ENST00000431572.2
MTIF3
mitochondrial translational initiation factor 3
chr10_-_17243579 0.02 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr10_+_96162242 0.02 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr11_+_3011093 0.02 ENST00000332881.2
AC131971.1
HCG1782999; PRO0943; Uncharacterized protein
chr6_-_46048116 0.01 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr1_+_223101757 0.01 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr12_-_57328187 0.01 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr6_+_147527103 0.01 ENST00000179882.6
STXBP5
syntaxin binding protein 5 (tomosyn)
chr11_+_7618413 0.01 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_176778803 0.01 ENST00000303127.7
LMAN2
lectin, mannose-binding 2
chr12_+_64173583 0.01 ENST00000261234.6
TMEM5
transmembrane protein 5
chr13_-_37633567 0.01 ENST00000464744.1
SUPT20H
suppressor of Ty 20 homolog (S. cerevisiae)
chr12_-_90049828 0.01 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_158901329 0.00 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr19_-_38916802 0.00 ENST00000587738.1
RASGRP4
RAS guanyl releasing protein 4
chr17_-_39623681 0.00 ENST00000225899.3
KRT32
keratin 32
chr6_+_150690133 0.00 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr10_-_61495760 0.00 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr14_+_101361107 0.00 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:0070839 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)