ISMARA results: SOX18

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX18

Z-value: 0.73

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Transcription factors associated with SOX18

Gene Symbol	Gene ID	Gene Info
SOX18 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000203883.5	SRY-box transcription factor 18

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX18	hg19_v2_chr20_-_62680984_62680999	-0.27	6.1e-01	Click!

Activity profile of SOX18 motif

Sorted Z-values of SOX18 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_42192189 Show fit	0.61	ENST00000401731.1 ENST00000338196.4 ENST00000006724.3	CEACAM7 Ensembl NCBI GeneCards UniProt NextProt Show fit	carcinoembryonic antigen-related cell adhesion molecule 7
chr1_+_37947257 Show fit	0.42	ENST00000471012.1	ZC3H12A Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 12A
chr2_+_101591314 Show fit	0.41	ENST00000450763.1	NPAS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal PAS domain protein 2
chr8_+_86999516 Show fit	0.41	ENST00000521564.1	ATP6V0D2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr5_-_146461027 Show fit	0.40	ENST00000394410.2 ENST00000508267.1 ENST00000504198.1	PPP2R2B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 2, regulatory subunit B, beta
chr17_+_41158742 Show fit	0.40	ENST00000415816.2 ENST00000438323.2	IFI35 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon-induced protein 35
chr10_-_4285923 Show fit	0.36	ENST00000418372.1 ENST00000608792.1	LINC00702 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 702
chr8_+_40010989 Show fit	0.34	ENST00000315792.3	C8orf4 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 8 open reading frame 4
chr6_-_133035185 Show fit	0.33	ENST00000367928.4	VNN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	vanin 1
chr19_-_12708113 Show fit	0.32	ENST00000440366.1	ZNF490 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 490

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX18

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:2000627	regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.0	0.4	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.0	0.4	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.3	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.3	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.3	GO:0051775	response to redox state(GO:0051775)
0.0	0.2	GO:0052565	response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.0	0.2	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.2	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.0	0.2	GO:0010819	regulation of T cell chemotaxis(GO:0010819)

Showing 1 to 10 of 30 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.4	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.3	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.3	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.0	0.2	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.1	GO:1903095	microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0	0.1	GO:0072517	viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0	0.1	GO:0009328	phenylalanine-tRNA ligase complex(GO:0009328)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0033186	CAF-1 complex(GO:0033186)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1	0.3	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.3	GO:0019826	oxygen sensor activity(GO:0019826)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.2	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.1	GO:0047389	glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0	0.1	GO:0004356	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation

Showing 1 to 3 of 3 entries

Results for SOX18

Z-value: 0.73

Motif logo

Transcription factors associated with SOX18

Activity-expression correlation:

Activity profile of SOX18 motif

Sorted Z-values of SOX18 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX18

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category: