Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for SMAD4
Z-value: 1.82
Motif logo
Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg19_v2_chr18_+_48556470_48556640 | -0.91 | 1.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_30752606 Show fit | 1.81 |
ENST00000399824.2
ENST00000405659.1 ENST00000338306.3 |
coiled-coil domain containing 157 |
|
| chr4_+_71384257 Show fit | 1.38 |
ENST00000339336.4
|
amelotin |
|
| chr2_+_113735575 Show fit | 1.24 |
ENST00000376489.2
ENST00000259205.4 |
interleukin 36, gamma |
|
| chr6_+_116937636 Show fit | 1.04 |
ENST00000368581.4
ENST00000229554.5 ENST00000368580.4 |
radial spoke head 4 homolog A (Chlamydomonas) |
|
| chr8_-_73793975 Show fit | 0.98 |
ENST00000523881.1
|
RP11-1145L24.1 |
|
| chr6_+_27791862 Show fit | 0.88 |
ENST00000355057.1
|
histone cluster 1, H4j |
|
| chr4_+_74606223 Show fit | 0.87 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr4_+_71384300 Show fit | 0.82 |
ENST00000504451.1
|
amelotin |
|
| chr8_+_104383759 Show fit | 0.82 |
ENST00000415886.2
|
collagen triple helix repeat containing 1 |
|
| chr22_+_38382163 Show fit | 0.80 |
ENST00000333418.4
ENST00000427034.1 |
polymerase (RNA) II (DNA directed) polypeptide F |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.8 | GO:0042488 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) |
| 0.2 | 1.9 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.2 | 1.5 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.0 | 1.3 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.3 | 1.0 | GO:0014028 | notochord formation(GO:0014028) |
| 0.3 | 1.0 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.3 | 0.9 | GO:0019364 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.2 | 0.9 | GO:1904806 | regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808) |
| 0.0 | 0.9 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.3 | 0.8 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.8 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 1.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.1 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 1.1 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 1.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.9 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 0.7 | GO:0034706 | sodium channel complex(GO:0034706) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.1 | 1.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 1.2 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.3 | 1.0 | GO:0015067 | amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068) |
| 0.0 | 1.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.9 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.9 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 0.7 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.6 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |