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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SMAD1
Z-value: 1.74
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402346_146402563 | -0.84 | 3.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.1 | 5.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 2.4 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.4 | 2.3 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.4 | 2.2 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 2.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.4 | 2.1 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.2 | 2.0 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.3 | 1.7 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 1.7 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 2.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 1.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.4 | 1.6 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 1.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.5 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 1.4 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 7.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.3 | 3.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 3.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 3.1 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.2 | 2.9 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.3 | 2.4 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 2.1 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 2.1 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 2.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.7 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.4 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 1.4 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.2 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 2.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |