Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for SHOX2_HOXC5
Z-value: 1.11
Motif logo
Transcription factors associated with SHOX2_HOXC5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SHOX2 | hg19_v2_chr3_-_157823839_157824078 | 0.73 | 9.6e-02 | Click! |
| HOXC5 | hg19_v2_chr12_+_54426637_54426637 | 0.56 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_119669160 Show fit | 1.04 |
ENST00000514240.1
|
CTC-552D5.1 |
|
| chr11_-_104817919 Show fit | 0.90 |
ENST00000533252.1
|
caspase 4, apoptosis-related cysteine peptidase |
|
| chr1_+_81001398 Show fit | 0.79 |
ENST00000418041.1
ENST00000443104.1 |
RP5-887A10.1 |
|
| chr8_-_65730127 Show fit | 0.66 |
ENST00000522106.1
|
RP11-1D12.2 |
|
| chr22_+_46476192 Show fit | 0.62 |
ENST00000443490.1
|
hsa-mir-4763 |
|
| chr8_+_105235572 Show fit | 0.56 |
ENST00000523362.1
|
regulating synaptic membrane exocytosis 2 |
|
| chr5_-_126409159 Show fit | 0.56 |
ENST00000607731.1
ENST00000535381.1 ENST00000296662.5 ENST00000509733.3 |
chromosome 5 open reading frame 63 |
|
| chr13_-_46742630 Show fit | 0.56 |
ENST00000416500.1
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr2_-_55496476 Show fit | 0.55 |
ENST00000441307.1
|
mitochondrial translational initiation factor 2 |
|
| chrX_+_13671225 Show fit | 0.52 |
ENST00000545566.1
ENST00000544987.1 ENST00000314720.4 |
transcription elongation factor A (SII) N-terminal and central domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of SHOX2_HOXC5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.0 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.7 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.0 | 0.7 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.0 | 0.6 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.0 | 0.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 0.5 | GO:0046356 | acetyl-CoA catabolic process(GO:0046356) |
| 0.1 | 0.5 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.1 | 0.5 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.0 | 0.5 | GO:0002438 | acute inflammatory response to antigenic stimulus(GO:0002438) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 1.2 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 0.4 | GO:0005715 | late recombination nodule(GO:0005715) |
| 0.1 | 0.4 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.1 | 0.4 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.4 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.7 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.1 | 0.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.0 | 0.6 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.2 | 0.5 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.0 | 0.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.4 | GO:1901375 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.0 | 0.4 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.4 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 0.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |