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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SCRT1_SCRT2
Z-value: 1.14
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Transcription factors associated with SCRT1_SCRT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SCRT1 | hg19_v2_chr8_-_145559943_145559943 | -0.16 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_165675197 Show fit | 1.40 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr4_-_6675550 Show fit | 0.85 |
ENST00000513179.1
ENST00000515205.1 |
RP11-539L10.3 |
|
| chr9_+_69650263 Show fit | 0.58 |
ENST00000322495.3
|
Protein LOC100996643 |
|
| chr4_+_165675269 Show fit | 0.55 |
ENST00000507311.1
|
RP11-294O2.2 |
|
| chr8_-_110988070 Show fit | 0.52 |
ENST00000524391.1
|
potassium channel, subfamily V, member 1 |
|
| chr3_+_181429704 Show fit | 0.48 |
ENST00000431565.2
ENST00000325404.1 |
SRY (sex determining region Y)-box 2 |
|
| chr15_+_76352178 Show fit | 0.47 |
ENST00000388942.3
|
chromosome 15 open reading frame 27 |
|
| chr13_+_96743093 Show fit | 0.46 |
ENST00000376705.2
|
heparan sulfate 6-O-sulfotransferase 3 |
|
| chr14_-_81902516 Show fit | 0.42 |
ENST00000554710.1
|
stonin 2 |
|
| chr8_-_33330595 Show fit | 0.41 |
ENST00000524021.1
ENST00000335589.3 |
fucosyltransferase 10 (alpha (1,3) fucosyltransferase) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SCRT1_SCRT2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.7 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.0 | 0.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.6 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.5 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.1 | 0.5 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
| 0.1 | 0.4 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.0 | 0.4 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.0 | 0.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 0.3 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 0.4 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 0.3 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 0.0 | 0.3 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.2 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.1 | GO:0070695 | FHF complex(GO:0070695) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.1 | 0.5 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.0 | 0.5 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.0 | 0.3 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.0 | 0.3 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 0.0 | 0.3 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.0 | 0.3 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |