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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RXRA_NR2F6_NR2C2
Z-value: 1.32
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Transcription factors associated with RXRA_NR2F6_NR2C2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000186350.8 | retinoid X receptor alpha | |
| ENSG00000160113.5 | nuclear receptor subfamily 2 group F member 6 | |
| ENSG00000177463.11 | nuclear receptor subfamily 2 group C member 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RXRA | hg19_v2_chr9_+_137218362_137218426 | 0.49 | 3.2e-01 | Click! |
| NR2C2 | hg19_v2_chr3_+_14989076_14989113 | -0.43 | 4.0e-01 | Click! |
| NR2F6 | hg19_v2_chr19_-_17356697_17356762 | 0.10 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39616410 Show fit | 1.08 |
ENST00000602004.1
ENST00000599470.1 ENST00000321944.4 ENST00000593480.1 ENST00000358301.3 ENST00000593690.1 ENST00000599386.1 |
p21 protein (Cdc42/Rac)-activated kinase 4 |
|
| chr17_+_37821593 Show fit | 1.00 |
ENST00000578283.1
|
titin-cap |
|
| chr5_+_172484377 Show fit | 0.93 |
ENST00000523161.1
|
CREB3 regulatory factor |
|
| chr14_-_24729251 Show fit | 0.93 |
ENST00000559136.1
|
transglutaminase 1 |
|
| chr19_-_48867291 Show fit | 0.87 |
ENST00000435956.3
|
transmembrane protein 143 |
|
| chr8_-_8639956 Show fit | 0.84 |
ENST00000522213.1
|
RP11-211C9.1 |
|
| chr17_-_2615031 Show fit | 0.82 |
ENST00000576885.1
ENST00000574426.2 |
clustered mitochondria (cluA/CLU1) homolog |
|
| chr14_-_69350920 Show fit | 0.80 |
ENST00000553290.1
|
actinin, alpha 1 |
|
| chr12_+_132413798 Show fit | 0.79 |
ENST00000440818.2
ENST00000542167.2 ENST00000538037.1 ENST00000456665.2 |
pseudouridylate synthase 1 |
|
| chr3_-_49203744 Show fit | 0.79 |
ENST00000321895.6
|
coiled-coil domain containing 71 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRA_NR2F6_NR2C2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0070902 | mitochondrial tRNA pseudouridine synthesis(GO:0070902) |
| 0.1 | 1.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 1.5 | GO:0003068 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 1.4 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 1.3 | GO:0038202 | TORC1 signaling(GO:0038202) |
| 0.0 | 1.3 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.4 | 1.1 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.2 | 1.1 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.1 | 1.1 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 1.4 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 1.4 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.8 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 0.8 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.8 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.7 | GO:0097165 | nuclear stress granule(GO:0097165) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0004730 | pseudouridylate synthase activity(GO:0004730) |
| 0.0 | 1.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 1.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 1.3 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 1.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 1.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 1.0 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 1.0 | GO:0005497 | androgen binding(GO:0005497) |
| 0.0 | 1.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 0.9 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.9 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.9 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.1 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.8 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |