Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for RUNX3_BCL11A
Z-value: 1.13
Motif logo
Transcription factors associated with RUNX3_BCL11A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL11A | hg19_v2_chr2_-_60780536_60780541 | -0.77 | 7.1e-02 | Click! |
| RUNX3 | hg19_v2_chr1_-_25291475_25291511 | 0.42 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.1 | 1.2 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 1.0 | GO:0002335 | mature B cell differentiation(GO:0002335) |
| 0.1 | 0.9 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 0.9 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 0.9 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.3 | 0.8 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.2 | 0.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.1 | 0.6 | GO:1904141 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141) |
| 0.0 | 0.6 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.9 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 0.5 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.5 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.3 | 1.0 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.1 | 1.0 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 0.9 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.3 | 0.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.3 | 0.8 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.1 | 0.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.6 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.0 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |