ISMARA results: RUNX1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RUNX1_RUNX2

Z-value: 1.38

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Transcription factors associated with RUNX1_RUNX2

Gene Symbol	Gene ID	Gene Info
RUNX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000159216.14	RUNX family transcription factor 1
RUNX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000124813.16	RUNX family transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RUNX1	hg19_v2_chr21_-_36259445_36259519	0.73	9.7e-02	Click!
RUNX2	hg19_v2_chr6_+_45390222_45390298	-0.31	5.5e-01	Click!

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_1606513 Show fit	1.64	ENST00000382171.2	KRTAP5-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 5-1
chr1_-_235098935 Show fit	1.13	ENST00000423175.1	RP11-443B7.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-443B7.1
chr1_+_149239529 Show fit	1.12	ENST00000457216.2	RP11-403I13.4 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-403I13.4
chr6_-_152623231 Show fit	0.84	ENST00000540663.1 ENST00000537033.1	SYNE1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin repeat containing, nuclear envelope 1
chr19_+_56989609 Show fit	0.79	ENST00000601875.1	ZNF667-AS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ZNF667 antisense RNA 1 (head to head)
chr22_+_21996549 Show fit	0.77	ENST00000248958.4	SDF2L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	stromal cell-derived factor 2-like 1
chr10_+_104221137 Show fit	0.63	ENST00000366277.2 ENST00000238936.4 ENST00000369931.3	TMEM180 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 180
chr11_-_64885111 Show fit	0.62	ENST00000528598.1 ENST00000310597.4	ZNHIT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger, HIT-type containing 2
chr18_+_52385068 Show fit	0.59	ENST00000586570.1	RAB27B Ensembl NCBI GeneCards UniProt NextProt Show fit	RAB27B, member RAS oncogene family
chr17_+_78193443 Show fit	0.58	ENST00000577155.1	SLC26A11 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 26 (anion exchanger), member 11

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0007340	acrosome reaction(GO:0007340)
0.1	0.9	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.8	GO:0046618	drug export(GO:0046618)
0.1	0.8	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.6	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.6	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1	0.5	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.1	0.5	GO:0051673	membrane disruption in other organism(GO:0051673)
0.1	0.5	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.5	GO:0015889	cobalamin transport(GO:0015889)

Showing 1 to 10 of 245 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0045095	keratin filament(GO:0045095)
0.0	1.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.9	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.5	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.0	0.5	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.5	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.4	GO:0035976	AP1 complex(GO:0035976)
0.0	0.4	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.9	GO:0005521	lamin binding(GO:0005521)
0.1	0.8	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.6	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.6	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.6	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	0.5	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.5	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.5	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.5	GO:0031419	cobalamin binding(GO:0031419)

Showing 1 to 10 of 146 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	ST GA13 PATHWAY	G alpha 13 Pathway
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.4	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.3	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Showing 1 to 10 of 17 entries

Results for RUNX1_RUNX2

Z-value: 1.38

Motif logo

Transcription factors associated with RUNX1_RUNX2

Activity-expression correlation:

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: