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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RORC

Z-value: 0.35

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804314_151804348-0.414.2e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_71485681 0.34 ENST00000391684.1
AC120194.1
AC120194.1
chr14_-_68157084 0.22 ENST00000557564.1
RP11-1012A1.4
RP11-1012A1.4
chr19_+_39759154 0.18 ENST00000331982.5
IFNL2
interferon, lambda 2
chrX_+_69501943 0.17 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr8_-_95449155 0.16 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr9_-_35042824 0.16 ENST00000595331.1
FLJ00273
FLJ00273
chr17_+_47439733 0.16 ENST00000507337.1
RP11-1079K10.3
RP11-1079K10.3
chr17_-_46623441 0.15 ENST00000330070.4
HOXB2
homeobox B2
chr4_+_85504075 0.15 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr19_-_49140609 0.14 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr1_-_211752073 0.14 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chrX_-_102531717 0.14 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5
chr2_+_160590469 0.12 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr20_-_44007014 0.12 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr14_-_54418598 0.11 ENST00000609748.1
ENST00000558961.1
BMP4
bone morphogenetic protein 4
chr19_-_49140692 0.10 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr3_-_45957088 0.10 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr19_-_46580352 0.10 ENST00000601672.1
IGFL4
IGF-like family member 4
chr14_+_23025534 0.09 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr8_+_124780672 0.08 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr11_+_13299186 0.08 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr12_+_4671352 0.08 ENST00000542744.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr3_-_45957534 0.08 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr2_-_148778323 0.08 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr6_+_89855765 0.08 ENST00000275072.4
PM20D2
peptidase M20 domain containing 2
chr3_+_187461442 0.08 ENST00000450760.1
RP11-211G3.2
RP11-211G3.2
chr11_-_10822029 0.07 ENST00000528839.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr17_+_44679808 0.07 ENST00000571172.1
NSF
N-ethylmaleimide-sensitive factor
chr18_-_23671139 0.07 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr4_-_1188922 0.06 ENST00000515004.1
ENST00000502483.1
SPON2
spondin 2, extracellular matrix protein
chr16_-_69385681 0.05 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr17_-_37764128 0.05 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr1_-_157069590 0.05 ENST00000454449.2
ETV3L
ets variant 3-like
chr4_-_87770416 0.05 ENST00000273905.6
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr7_+_112063192 0.04 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr14_-_23451467 0.04 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr19_-_10450287 0.04 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr12_+_93963590 0.03 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr3_+_160559931 0.03 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr1_-_150207017 0.03 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_+_140586922 0.03 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr13_+_109248500 0.03 ENST00000356711.2
MYO16
myosin XVI
chr2_+_162016827 0.03 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr4_-_159094194 0.03 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr10_-_103578182 0.03 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr2_+_162016916 0.03 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr1_-_217311090 0.02 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr1_+_171810606 0.02 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr14_-_23755297 0.02 ENST00000357460.5
HOMEZ
homeobox and leucine zipper encoding
chr17_-_48785216 0.02 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr1_+_114447763 0.02 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr10_-_105845674 0.02 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr12_+_56414795 0.02 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_62190793 0.02 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr1_+_205197304 0.01 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr1_+_104198377 0.01 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr4_-_170948361 0.01 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr1_-_153522562 0.01 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr17_-_10707410 0.01 ENST00000581851.1
LINC00675
long intergenic non-protein coding RNA 675
chr1_+_154540246 0.01 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr10_-_103578162 0.01 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr1_-_145826450 0.01 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr9_-_110251836 0.01 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr1_+_26869597 0.01 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_-_111927062 0.01 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr1_-_185286461 0.00 ENST00000367498.3
IVNS1ABP
influenza virus NS1A binding protein
chr12_+_93964158 0.00 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr3_-_65583561 0.00 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr14_-_23451845 0.00 ENST00000262713.2
AJUBA
ajuba LIM protein

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)