ISMARA results: RORA

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RORA

Z-value: 0.84

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Transcription factors associated with RORA

Gene Symbol	Gene ID	Gene Info
RORA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000069667.11	RAR related orphan receptor A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RORA	hg19_v2_chr15_-_60885287_60885325	-0.58	2.2e-01	Click!

Activity profile of RORA motif

Sorted Z-values of RORA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_49140692 Show fit	0.74	ENST00000222122.5	DBP Ensembl NCBI GeneCards UniProt NextProt Show fit	D site of albumin promoter (albumin D-box) binding protein
chrX_-_43741594 Show fit	0.63	ENST00000536181.1 ENST00000378069.4	MAOB Ensembl NCBI GeneCards UniProt NextProt Show fit	monoamine oxidase B
chr5_-_126409159 Show fit	0.62	ENST00000607731.1 ENST00000535381.1 ENST00000296662.5 ENST00000509733.3	C5orf63 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 5 open reading frame 63
chr1_-_85156417 Show fit	0.45	ENST00000422026.1	SSX2IP Ensembl NCBI GeneCards UniProt NextProt Show fit	synovial sarcoma, X breakpoint 2 interacting protein
chr12_+_25205155 Show fit	0.41	ENST00000550945.1	LRMP Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphoid-restricted membrane protein
chr3_+_46449049 Show fit	0.41	ENST00000357392.4 ENST00000400880.3 ENST00000433848.1	CCRL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) receptor-like 2
chr3_-_123339343 Show fit	0.40	ENST00000578202.1	MYLK Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain kinase
chr2_-_177502659 Show fit	0.38	ENST00000295549.4	AC017048.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 1116
chr15_+_76352178 Show fit	0.37	ENST00000388942.3	C15orf27 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 15 open reading frame 27
chr16_-_4164027 Show fit	0.35	ENST00000572288.1	ADCY9 Ensembl NCBI GeneCards UniProt NextProt Show fit	adenylate cyclase 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.1	0.7	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.6	GO:0014063	negative regulation of serotonin secretion(GO:0014063)
0.1	0.5	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.5	GO:0007340	acrosome reaction(GO:0007340)
0.1	0.4	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.1	0.3	GO:0090299	regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0	0.3	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.3	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.3	GO:0006477	protein sulfation(GO:0006477)

Showing 1 to 10 of 39 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.4	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1	0.3	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.0	0.3	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	0.3	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	0.3	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:1990584	cardiac Troponin complex(GO:1990584)
0.0	0.1	GO:0005927	muscle tendon junction(GO:0005927)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0008131	primary amine oxidase activity(GO:0008131)
0.1	0.7	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.5	GO:0004887	thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.0	0.5	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.5	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	0.4	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.4	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.4	GO:0004383	guanylate cyclase activity(GO:0004383)
0.1	0.3	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0	0.3	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	0.3	REACTOME OPSINS	Genes involved in Opsins
0.0	0.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 4 of 4 entries

Results for RORA

Z-value: 0.84

Motif logo

Transcription factors associated with RORA

Activity-expression correlation:

Activity profile of RORA motif

Sorted Z-values of RORA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: