ISMARA results: RFX3

Project

NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for RFX3_RFX2

Z-value: 1.76

Motif logo

Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000080298.11	regulatory factor X3
RFX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000087903.8	regulatory factor X2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX2	hg19_v2_chr19_-_6057282_6057313	-0.51	3.0e-01	Click!
RFX3	hg19_v2_chr9_-_3489428_3489437	0.39	4.5e-01	Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_154178803 Show fit	1.36	ENST00000368525.3	C1orf189 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 189
chr1_+_161068179 Show fit	1.34	ENST00000368011.4 ENST00000392192.2	KLHDC9 Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch domain containing 9
chr17_-_7108436 Show fit	1.11	ENST00000493294.1	DLG4 Ensembl NCBI GeneCards UniProt NextProt Show fit	discs, large homolog 4 (Drosophila)
chr2_-_74648702 Show fit	0.98	ENST00000518863.1	C2orf81 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 2 open reading frame 81
chr14_+_52313833 Show fit	0.94	ENST00000553560.1	GNG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanine nucleotide binding protein (G protein), gamma 2
chr1_-_86861660 Show fit	0.93	ENST00000486215.1	ODF2L Ensembl NCBI GeneCards UniProt NextProt Show fit	outer dense fiber of sperm tails 2-like
chr19_-_51017881 Show fit	0.89	ENST00000601207.1 ENST00000598657.1 ENST00000376916.3	ASPDH Ensembl NCBI GeneCards UniProt NextProt Show fit	aspartate dehydrogenase domain containing
chr14_+_78227105 Show fit	0.85	ENST00000439131.2 ENST00000355883.3 ENST00000557011.1 ENST00000556047.1	C14orf178 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 14 open reading frame 178
chr1_-_173638976 Show fit	0.84	ENST00000333279.2	ANKRD45 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat domain 45
chr2_-_202222091 Show fit	0.78	ENST00000405148.2 ENST00000392257.3 ENST00000439709.1	ALS2CR12 Ensembl NCBI GeneCards UniProt NextProt Show fit	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.3	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.4	1.2	GO:0006742	NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1	1.2	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.1	1.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	1.1	GO:0044375	regulation of peroxisome size(GO:0044375)
0.1	1.1	GO:0097113	AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0	1.1	GO:0035082	axoneme assembly(GO:0035082)
0.0	1.0	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	0.9	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1	0.8	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0098839	postsynaptic density membrane(GO:0098839)
0.0	1.1	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	1.1	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	0.8	GO:0033503	HULC complex(GO:0033503)
0.2	0.7	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.5	GO:0034464	BBSome(GO:0034464)
0.0	0.5	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.5	GO:0016342	catenin complex(GO:0016342)
0.0	0.5	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	1.2	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.3	1.1	GO:0031812	G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1	0.9	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.8	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.8	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	0.7	GO:0070568	guanylyltransferase activity(GO:0070568)
0.0	0.7	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.7	GO:0045503	dynein light chain binding(GO:0045503)

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Total log-likelihood	Term	Description
1.5	PID RAS PATHWAY	Regulation of Ras family activation
1.2	ST ADRENERGIC	Adrenergic Pathway
1.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.9	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.9	PID ARF6 PATHWAY	Arf6 signaling events
0.6	PID IL3 PATHWAY	IL3-mediated signaling events

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Total log-likelihood	Term	Description
1.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.7	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.7	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.6	REACTOME KINESINS	Genes involved in Kinesins
0.4	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.3	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation

Showing 1 to 10 of 10 entries

Results for RFX3_RFX2

Z-value: 1.76

Motif logo

Transcription factors associated with RFX3_RFX2

Activity-expression correlation:

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: