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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RELA

Z-value: 3.58

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Transcription factors associated with RELA

Gene Symbol Gene ID Gene Info
RELA
ENSG00000173039.14 RELA proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELAhg19_v2_chr11_-_65430554_654305790.285.9e-01Click!

Activity profile of RELA motif

Sorted Z-values of RELA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74904398 11.95 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr6_+_138188551 8.98 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_+_138188351 8.98 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr4_-_74864386 8.75 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr2_+_228678550 8.66 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr6_+_138188378 8.25 ENST00000420009.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr5_+_159895275 7.90 ENST00000517927.1
MIR146A
microRNA 146a
chr4_-_74964904 7.86 ENST00000508487.2
CXCL2
chemokine (C-X-C motif) ligand 2
chr7_+_22766766 7.24 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr14_-_35873856 6.73 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr11_+_102188272 6.58 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr5_-_150460914 5.78 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr4_+_74735102 5.75 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr11_+_102188224 5.72 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr10_+_104154229 5.35 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr5_-_150467221 4.62 ENST00000522226.1
TNIP1
TNFAIP3 interacting protein 1
chr11_+_18287801 4.18 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr11_+_18287721 4.16 ENST00000356524.4
SAA1
serum amyloid A1
chr6_-_31550192 4.16 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr14_+_103589789 4.04 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr5_-_150460539 3.90 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNIP1
TNFAIP3 interacting protein 1
chr4_+_74702214 3.87 ENST00000226317.5
ENST00000515050.1
CXCL6
chemokine (C-X-C motif) ligand 6
chr19_+_10381769 3.82 ENST00000423829.2
ENST00000588645.1
ICAM1
intercellular adhesion molecule 1
chr10_+_30723045 3.70 ENST00000542547.1
ENST00000415139.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr10_+_30723105 3.68 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr12_-_49259643 3.66 ENST00000309739.5
RND1
Rho family GTPase 1
chr19_+_45504688 3.62 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr4_-_76944621 3.48 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr5_-_150466692 3.41 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr3_+_101546827 3.34 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr10_+_30722866 3.34 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr14_+_103243813 2.72 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr17_+_40440481 2.56 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr14_+_75988851 2.52 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr10_+_104155450 2.43 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr4_+_103422471 2.19 ENST00000226574.4
ENST00000394820.4
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_-_30712313 1.94 ENST00000376377.2
ENST00000259874.5
IER3
immediate early response 3
chr3_-_4793274 1.74 ENST00000414938.1
EGOT
eosinophil granule ontogeny transcript (non-protein coding)
chr4_+_103422499 1.57 ENST00000511926.1
ENST00000507079.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_+_45251804 1.55 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr1_-_89738528 1.47 ENST00000343435.5
GBP5
guanylate binding protein 5
chr6_+_106534192 1.46 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr8_+_72755367 1.42 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr5_-_149792295 1.39 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr10_+_12391685 1.38 ENST00000378845.1
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr17_+_40440094 1.33 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr20_-_62203808 1.32 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr1_-_186649543 1.23 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_67632083 1.18 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr2_-_191885686 1.17 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr10_+_75668916 1.16 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr6_+_33378517 1.14 ENST00000428274.1
PHF1
PHD finger protein 1
chr6_-_29527702 1.12 ENST00000377050.4
UBD
ubiquitin D
chr6_+_29691198 1.08 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr11_-_57194111 1.08 ENST00000529112.1
ENST00000529896.1
SLC43A3
solute carrier family 43, member 3
chr11_-_128392085 1.03 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr16_+_50730910 1.02 ENST00000300589.2
NOD2
nucleotide-binding oligomerization domain containing 2
chr15_+_42066888 1.01 ENST00000510535.1
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr2_-_163175133 1.00 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr9_-_136344197 0.97 ENST00000414172.1
ENST00000371897.4
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
chr4_-_122085469 0.95 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr11_+_73000449 0.94 ENST00000535931.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_-_4338838 0.94 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr12_-_62997214 0.93 ENST00000408887.2
C12orf61
chromosome 12 open reading frame 61
chr5_-_141338377 0.92 ENST00000510041.1
PCDH12
protocadherin 12
chr11_-_58345569 0.90 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr17_-_4852332 0.89 ENST00000572383.1
PFN1
profilin 1
chr19_+_40873617 0.89 ENST00000599353.1
PLD3
phospholipase D family, member 3
chr19_-_4338783 0.88 ENST00000601482.1
ENST00000600324.1
STAP2
signal transducing adaptor family member 2
chr1_-_209825674 0.88 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr19_+_4229495 0.87 ENST00000221847.5
EBI3
Epstein-Barr virus induced 3
chr6_-_32122106 0.86 ENST00000428778.1
PRRT1
proline-rich transmembrane protein 1
chr1_+_110453203 0.85 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr14_-_69446034 0.85 ENST00000193403.6
ACTN1
actinin, alpha 1
chr2_+_64681641 0.84 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr12_-_49581152 0.82 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr20_+_44746885 0.81 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr17_-_61776522 0.80 ENST00000582055.1
LIMD2
LIM domain containing 2
chr10_+_99609996 0.80 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr1_+_6845384 0.79 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr20_-_43977055 0.77 ENST00000372733.3
ENST00000537976.1
SDC4
syndecan 4
chr16_+_53242350 0.77 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr7_-_93520259 0.76 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr5_+_118604385 0.76 ENST00000274456.6
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_+_50775948 0.73 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr6_+_30297306 0.72 ENST00000420746.1
ENST00000513556.1
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr3_+_184033551 0.70 ENST00000456033.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_+_110407390 0.70 ENST00000344895.3
TSLP
thymic stromal lymphopoietin
chr5_+_118604439 0.69 ENST00000388882.5
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr1_-_155947951 0.69 ENST00000313695.7
ENST00000497907.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_+_184032919 0.69 ENST00000427845.1
ENST00000342981.4
ENST00000319274.6
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_-_138842286 0.69 ENST00000515823.1
ECSCR
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr6_+_29691056 0.69 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr9_-_117568365 0.68 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr19_-_46272106 0.64 ENST00000560168.1
SIX5
SIX homeobox 5
chr2_-_240230890 0.64 ENST00000446876.1
HDAC4
histone deacetylase 4
chr12_-_28124903 0.63 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr12_-_48499826 0.62 ENST00000551798.1
SENP1
SUMO1/sentrin specific peptidase 1
chr7_+_143771275 0.62 ENST00000408898.2
OR2A25
olfactory receptor, family 2, subfamily A, member 25
chr17_-_61777090 0.62 ENST00000578061.1
LIMD2
LIM domain containing 2
chr3_-_156878482 0.61 ENST00000295925.4
CCNL1
cyclin L1
chr16_-_66959429 0.61 ENST00000420652.1
ENST00000299759.6
RRAD
Ras-related associated with diabetes
chr10_+_30723533 0.61 ENST00000413724.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr18_+_32290218 0.61 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr21_+_34775698 0.60 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr19_-_4831701 0.59 ENST00000248244.5
TICAM1
toll-like receptor adaptor molecule 1
chr1_+_110453462 0.59 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr19_-_46145696 0.58 ENST00000588172.1
EML2
echinoderm microtubule associated protein like 2
chr3_+_157154578 0.57 ENST00000295927.3
PTX3
pentraxin 3, long
chrX_+_48755183 0.57 ENST00000376563.1
ENST00000376566.4
PQBP1
polyglutamine binding protein 1
chr4_-_76957214 0.56 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_+_169077133 0.56 ENST00000494797.1
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr16_+_50775971 0.56 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr22_+_41347363 0.56 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr4_-_185395191 0.55 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr3_+_184033135 0.54 ENST00000424196.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr19_-_47734448 0.53 ENST00000439096.2
BBC3
BCL2 binding component 3
chrX_-_48901012 0.53 ENST00000315869.7
TFE3
transcription factor binding to IGHM enhancer 3
chr7_-_100881109 0.53 ENST00000308344.5
CLDN15
claudin 15
chr16_+_50776021 0.52 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr1_-_204436344 0.51 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr1_-_155959853 0.51 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr16_+_53738053 0.50 ENST00000394647.3
FTO
fat mass and obesity associated
chr19_-_4182530 0.50 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr1_-_39395165 0.50 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr21_+_34775772 0.50 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr7_+_18548924 0.50 ENST00000524023.1
HDAC9
histone deacetylase 9
chr19_+_3721719 0.49 ENST00000589378.1
ENST00000382008.3
TJP3
tight junction protein 3
chr7_+_18548878 0.49 ENST00000456174.2
HDAC9
histone deacetylase 9
chr9_-_140115775 0.48 ENST00000391553.1
ENST00000392827.1
RNF208
ring finger protein 208
chr11_+_10476851 0.48 ENST00000396553.2
AMPD3
adenosine monophosphate deaminase 3
chr1_+_155657737 0.47 ENST00000471642.2
ENST00000471214.1
DAP3
death associated protein 3
chr4_-_103749179 0.47 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_-_155658085 0.47 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr5_-_43313269 0.47 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_-_94079648 0.47 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr3_+_119814070 0.46 ENST00000469070.1
RP11-18H7.1
RP11-18H7.1
chr2_+_97202480 0.46 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr11_+_72525353 0.45 ENST00000321297.5
ENST00000534905.1
ENST00000540567.1
ATG16L2
autophagy related 16-like 2 (S. cerevisiae)
chr5_+_14143728 0.45 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr17_+_21191341 0.45 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr10_+_89124746 0.45 ENST00000465545.1
NUTM2D
NUT family member 2D
chr14_-_24616426 0.45 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr7_-_93520191 0.44 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr6_+_292253 0.44 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22
dual specificity phosphatase 22
chr9_-_32526184 0.43 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_146560245 0.43 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr8_+_38758845 0.43 ENST00000519640.1
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr7_+_44663908 0.42 ENST00000543843.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr19_-_11688951 0.41 ENST00000589792.1
ACP5
acid phosphatase 5, tartrate resistant
chr1_-_38100539 0.40 ENST00000401069.1
RSPO1
R-spondin 1
chr21_+_34775181 0.40 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr3_+_197518100 0.40 ENST00000438796.2
ENST00000414675.2
ENST00000441090.2
ENST00000334859.4
ENST00000425562.2
LRCH3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr9_-_32526299 0.38 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_48499883 0.38 ENST00000546755.1
ENST00000549366.1
ENST00000552792.1
PFKM
phosphofructokinase, muscle
chr12_-_76425368 0.37 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr17_-_46682321 0.37 ENST00000225648.3
ENST00000484302.2
HOXB6
homeobox B6
chr1_-_209824643 0.37 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr1_+_169077172 0.37 ENST00000499679.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr14_-_21852119 0.37 ENST00000555943.1
SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr12_+_110011571 0.37 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr5_-_132112921 0.36 ENST00000378721.4
ENST00000378701.1
SEPT8
septin 8
chr16_+_67571351 0.36 ENST00000428437.2
ENST00000569253.1
FAM65A
family with sequence similarity 65, member A
chr2_-_206950996 0.36 ENST00000414320.1
INO80D
INO80 complex subunit D
chr1_-_113249678 0.36 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
RHOC
ras homolog family member C
chr6_+_135502466 0.35 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr18_+_3450161 0.35 ENST00000551402.1
ENST00000577543.1
TGIF1
TGFB-induced factor homeobox 1
chr15_-_42302445 0.35 ENST00000413860.2
PLA2G4E
phospholipase A2, group IVE
chr5_-_58652788 0.34 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_18488137 0.34 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr19_-_39390212 0.33 ENST00000437828.1
SIRT2
sirtuin 2
chr1_-_65432171 0.33 ENST00000342505.4
JAK1
Janus kinase 1
chr5_+_133984462 0.33 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr16_-_28223166 0.33 ENST00000304658.5
XPO6
exportin 6
chr5_-_132112907 0.33 ENST00000458488.2
SEPT8
septin 8
chr17_+_40719073 0.33 ENST00000435881.2
ENST00000246912.4
ENST00000346833.4
ENST00000591024.1
MLX
MLX, MAX dimerization protein
chr20_-_2451395 0.33 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr19_-_54984354 0.33 ENST00000301200.2
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr12_+_49761147 0.33 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr16_-_28222797 0.32 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chr11_+_6624955 0.32 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr12_+_49761273 0.32 ENST00000551540.1
ENST00000552918.1
ENST00000548777.1
ENST00000547865.1
ENST00000552171.1
SPATS2
spermatogenesis associated, serine-rich 2
chr3_-_49131473 0.31 ENST00000430979.1
ENST00000357496.2
ENST00000437939.1
QRICH1
glutamine-rich 1
chr20_+_18488528 0.31 ENST00000377465.1
SEC23B
Sec23 homolog B (S. cerevisiae)
chr7_+_143078652 0.30 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr17_+_16318850 0.30 ENST00000338560.7
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr5_-_54468974 0.29 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B
cell division cycle 20B
chr12_+_11802753 0.29 ENST00000396373.4
ETV6
ets variant 6
chr1_+_8021954 0.29 ENST00000377491.1
ENST00000377488.1
PARK7
parkinson protein 7
chr16_+_3096638 0.29 ENST00000336577.4
MMP25
matrix metallopeptidase 25
chr3_+_9439400 0.29 ENST00000450326.1
ENST00000402198.1
ENST00000402466.1
SETD5
SET domain containing 5
chr10_+_13142075 0.29 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
OPTN
optineurin
chr1_-_46664074 0.29 ENST00000371986.3
ENST00000371984.3
POMGNT1
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
chr7_+_143013198 0.28 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr19_-_51471381 0.28 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr1_-_113249734 0.28 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
RHOC
ras homolog family member C
chr8_-_93115445 0.28 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_61108449 0.28 ENST00000439412.1
ENST00000452343.1
AC010733.4
AC010733.4
chr2_+_201987200 0.28 ENST00000425030.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_+_26872324 0.28 ENST00000531382.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 26.2 GO:0034148 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
3.5 17.7 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
2.9 8.7 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
2.3 9.3 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
1.8 7.2 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
1.5 40.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
1.3 6.7 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.3 3.8 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
1.2 12.3 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.8 3.9 GO:0000255 allantoin metabolic process(GO:0000255)
0.7 4.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.6 3.8 GO:0097368 membrane to membrane docking(GO:0022614) establishment of Sertoli cell barrier(GO:0097368)
0.6 1.8 GO:1990108 protein linear deubiquitination(GO:1990108)
0.5 1.0 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.5 1.5 GO:0072616 interleukin-18 secretion(GO:0072616)
0.5 1.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.5 1.8 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.4 4.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.4 1.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.4 2.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.3 1.6 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.3 1.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.3 1.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 0.6 GO:0001878 response to yeast(GO:0001878)
0.2 4.0 GO:0051601 exocyst localization(GO:0051601)
0.2 1.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.2 8.2 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.2 0.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 1.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 3.7 GO:0016322 neuron remodeling(GO:0016322)
0.2 6.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 0.5 GO:1903093 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.2 0.5 GO:0042245 RNA repair(GO:0042245)
0.2 1.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.2 0.8 GO:0033590 response to cobalamin(GO:0033590)
0.2 0.8 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 1.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.4 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.1 0.9 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.1 11.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.9 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 1.0 GO:0030578 PML body organization(GO:0030578)
0.1 1.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.4 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.6 GO:0045080 positive regulation of chemokine biosynthetic process(GO:0045080)
0.1 0.4 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 1.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.4 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.9 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.4 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.5 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.5 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.5 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.4 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.4 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 0.3 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 0.6 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.3 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.6 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 1.5 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.3 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.0 0.4 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 0.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.7 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.5 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.1 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.2 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.4 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0036343 psychomotor behavior(GO:0036343)
0.0 1.2 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.3 GO:0030091 protein repair(GO:0030091)
0.0 1.0 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.3 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.1 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.3 GO:0060022 hard palate development(GO:0060022)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782)
0.0 1.3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.1 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.0 0.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
1.4 7.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.3 12.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 8.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.2 1.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 1.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.2 0.6 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 1.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 2.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 1.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.4 GO:0035101 FACT complex(GO:0035101)
0.1 1.2 GO:0005610 laminin-5 complex(GO:0005610)
0.1 4.0 GO:0000145 exocyst(GO:0000145)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.8 GO:0001772 immunological synapse(GO:0001772)
0.1 4.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.2 GO:0097342 ripoptosome(GO:0097342)
0.0 0.4 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.8 GO:0005916 fascia adherens(GO:0005916)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 1.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 2.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 20.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 11.1 GO:0045121 membrane raft(GO:0045121)
0.0 40.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0044449 contractile fiber part(GO:0044449)
0.0 1.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 42.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.9 8.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.5 28.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.7 7.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 17.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.3 11.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 1.8 GO:0046979 TAP2 binding(GO:0046979)
0.2 1.5 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.2 1.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.2 1.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 1.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.2 11.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.4 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 1.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 2.7 GO:0031996 thioesterase binding(GO:0031996)
0.2 7.8 GO:0042056 chemoattractant activity(GO:0042056)
0.1 6.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.9 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.5 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.1 0.4 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.1 0.4 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.9 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 3.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0046790 complement component C1q binding(GO:0001849) virion binding(GO:0046790)
0.1 0.3 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1 0.6 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.6 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.9 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 0.3 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 1.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.5 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 2.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.4 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.0 1.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.7 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 1.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 2.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 4.0 GO:0000149 SNARE binding(GO:0000149)
0.0 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 5.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 55.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.5 11.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 13.1 PID IL27 PATHWAY IL27-mediated signaling events
0.2 8.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 7.1 PID IL23 PATHWAY IL23-mediated signaling events
0.1 45.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 3.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 5.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 ST ADRENERGIC Adrenergic Pathway
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.9 ST GAQ PATHWAY G alpha q Pathway
0.0 1.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 PID P73PATHWAY p73 transcription factor network
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 51.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.7 41.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.6 22.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.4 8.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 11.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 3.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 1.8 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 1.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 5.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix