Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for RELA
Z-value: 3.58
Motif logo
Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | 0.28 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 40.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 8.7 | 26.2 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 3.5 | 17.7 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 1.2 | 12.3 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.1 | 11.2 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 2.3 | 9.3 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 2.9 | 8.7 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.2 | 8.2 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 1.8 | 7.2 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 1.3 | 6.7 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 20.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 1.3 | 12.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 11.1 | GO:0045121 | membrane raft(GO:0045121) |
| 2.3 | 9.3 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.3 | 8.3 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 1.4 | 7.2 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 4.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 4.0 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.8 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 42.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.5 | 28.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 17.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 11.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.3 | 11.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 2.9 | 8.7 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.2 | 7.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.7 | 7.2 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 6.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 5.1 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 55.9 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 45.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 13.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.5 | 11.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 8.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 7.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 5.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 3.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 51.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 41.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.6 | 22.0 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.3 | 11.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.4 | 8.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 5.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 3.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 3.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.2 | 1.8 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |