Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for REL
Z-value: 2.09
Motif logo
Transcription factors associated with REL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REL | hg19_v2_chr2_+_61108771_61108791 | -0.56 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_138188351 Show fit | 5.39 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr6_+_138188551 Show fit | 5.25 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr6_+_138188378 Show fit | 4.91 |
ENST00000420009.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr4_-_74864386 Show fit | 3.91 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr2_+_228678550 Show fit | 3.83 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr5_-_150467221 Show fit | 2.80 |
ENST00000522226.1
|
TNFAIP3 interacting protein 1 |
|
| chr4_+_74735102 Show fit | 2.61 |
ENST00000395761.3
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
| chr11_+_102188272 Show fit | 2.59 |
ENST00000532808.1
|
baculoviral IAP repeat containing 3 |
|
| chr14_+_103589789 Show fit | 2.48 |
ENST00000558056.1
ENST00000560869.1 |
tumor necrosis factor, alpha-induced protein 2 |
|
| chr5_-_150460914 Show fit | 2.41 |
ENST00000389378.2
|
TNFAIP3 interacting protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of REL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 15.5 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.4 | 10.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.4 | 7.2 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.4 | 4.9 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 1.3 | 3.8 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.8 | 3.0 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 2.5 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 2.4 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 2.0 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 1.8 | GO:0007620 | copulation(GO:0007620) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.8 | 3.0 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 3.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 2.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 1.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 1.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 0.9 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 0.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.7 | GO:0035631 | CD40 receptor complex(GO:0035631) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.8 | 10.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 7.2 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 4.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 1.3 | 3.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 2.6 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.1 | 2.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 1.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.7 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 1.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 13.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.0 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 3.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.9 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 0.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.3 | 15.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.4 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.0 | 2.1 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 1.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 1.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 1.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |