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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RCOR1_MTA3
Z-value: 1.33
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.92 | 9.4e-03 | Click! |
| MTA3 | hg19_v2_chr2_+_42795745_42795824 | 0.83 | 4.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_48673465 Show fit | 2.12 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr21_+_38338737 Show fit | 2.08 |
ENST00000430068.1
|
AP000704.5 |
|
| chr21_+_37529055 Show fit | 1.76 |
ENST00000270190.4
|
dopey family member 2 |
|
| chr9_+_96928516 Show fit | 1.48 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr6_-_110500826 Show fit | 1.42 |
ENST00000265601.3
ENST00000447287.1 ENST00000444391.1 |
WAS protein family, member 1 |
|
| chr10_-_126849626 Show fit | 1.37 |
ENST00000530884.1
|
C-terminal binding protein 2 |
|
| chr3_+_121554046 Show fit | 1.29 |
ENST00000273668.2
ENST00000451944.2 |
ELL associated factor 2 |
|
| chr2_-_178129551 Show fit | 1.27 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
|
| chr9_-_4679419 Show fit | 1.22 |
ENST00000609131.1
ENST00000607997.1 |
RP11-6J24.6 |
|
| chr17_-_72968837 Show fit | 1.18 |
ENST00000581676.1
|
HID1 domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 4.0 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 3.7 | GO:0051383 | kinetochore organization(GO:0051383) |
| 0.0 | 3.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 3.4 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.1 | 3.1 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 3.0 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 2.9 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.2 | 2.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 2.8 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 6.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 5.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 5.1 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.0 | 4.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 4.5 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 4.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 4.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 3.9 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 3.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 6.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 6.1 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 5.8 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 4.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 4.1 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 4.0 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 3.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 3.7 | GO:0030276 | clathrin binding(GO:0030276) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 8.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 7.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.5 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 9.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 5.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 5.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 5.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 3.9 | REACTOME NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Neurotransmitter Release Cycle |
| 0.0 | 3.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 3.4 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |