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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RBPJ
Z-value: 1.03
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Transcription factors associated with RBPJ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RBPJ | hg19_v2_chr4_+_26165074_26165110 | 0.49 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_55467072 Show fit | 0.90 |
ENST00000602362.1
|
RP11-53M11.3 |
|
| chr17_-_70417365 Show fit | 0.79 |
ENST00000580948.1
|
long intergenic non-protein coding RNA 511 |
|
| chr10_-_4285923 Show fit | 0.73 |
ENST00000418372.1
ENST00000608792.1 |
long intergenic non-protein coding RNA 702 |
|
| chr11_+_64053311 Show fit | 0.64 |
ENST00000540370.1
|
G protein-coupled receptor 137 |
|
| chr4_-_87515202 Show fit | 0.60 |
ENST00000502302.1
ENST00000513186.1 |
mitogen-activated protein kinase 10 |
|
| chr8_-_80680078 Show fit | 0.57 |
ENST00000337919.5
ENST00000354724.3 |
hes-related family bHLH transcription factor with YRPW motif 1 |
|
| chr8_+_55466915 Show fit | 0.56 |
ENST00000522711.2
|
RP11-53M11.3 |
|
| chr2_-_25451065 Show fit | 0.48 |
ENST00000606328.1
|
RP11-458N5.1 |
|
| chr1_-_2461684 Show fit | 0.45 |
ENST00000378453.3
|
hes family bHLH transcription factor 5 |
|
| chr1_-_197744763 Show fit | 0.42 |
ENST00000422998.1
|
DENN/MADD domain containing 1B |
Network of associatons between targets according to the STRING database.
First level regulatory network of RBPJ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820) |
| 0.0 | 0.6 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 0.5 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
| 0.1 | 0.4 | GO:1902530 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.1 | 0.4 | GO:1904835 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) sensory neuron axon guidance(GO:0097374) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.0 | 0.4 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.1 | 0.3 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.0 | 0.3 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.0 | 0.2 | GO:2001183 | negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.0 | 0.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 0.1 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
| 0.0 | 0.1 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.1 | GO:0031417 | NatC complex(GO:0031417) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 0.6 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.4 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.0 | 0.3 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.0 | 0.3 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 0.1 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 0.1 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.0 | 0.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |