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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PRRX1_ALX4_PHOX2A
Z-value: 0.90
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Transcription factors associated with PRRX1_ALX4_PHOX2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX1 | hg19_v2_chr1_+_170633047_170633084 | 0.53 | 2.8e-01 | Click! |
| ALX4 | hg19_v2_chr11_-_44331679_44331716 | -0.29 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_107235331 Show fit | 1.10 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr5_+_36606700 Show fit | 1.06 |
ENST00000416645.2
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
|
| chr8_+_86999516 Show fit | 0.82 |
ENST00000521564.1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 |
|
| chr10_+_69865866 Show fit | 0.65 |
ENST00000354393.2
|
myopalladin |
|
| chr14_+_95078714 Show fit | 0.65 |
ENST00000393078.3
ENST00000393080.4 ENST00000467132.1 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
|
| chr18_+_20714525 Show fit | 0.60 |
ENST00000400473.2
|
Cdk5 and Abl enzyme substrate 1 |
|
| chr1_+_50459990 Show fit | 0.60 |
ENST00000448346.1
|
AL645730.2 |
|
| chr2_-_114461655 Show fit | 0.57 |
ENST00000424612.1
|
AC017074.2 |
|
| chr4_-_103940791 Show fit | 0.56 |
ENST00000510559.1
ENST00000394789.3 ENST00000296422.7 |
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 |
|
| chr13_-_81801115 Show fit | 0.48 |
ENST00000567258.1
|
long intergenic non-protein coding RNA 564 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRRX1_ALX4_PHOX2A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.9 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.7 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.7 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 0.6 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.1 | 0.5 | GO:0042710 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.1 | 0.4 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.0 | 0.4 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.3 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.2 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.2 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.0 | 0.2 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 0.1 | GO:0043614 | multi-eIF complex(GO:0043614) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 0.9 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.6 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 0.3 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |