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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRDM4

Z-value: 0.29

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154705_1081547760.815.2e-02Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_42634844 0.19 ENST00000315323.3
FZD2
frizzled family receptor 2
chr11_-_85393886 0.17 ENST00000534224.1
CREBZF
CREB/ATF bZIP transcription factor
chr20_-_49639631 0.16 ENST00000424171.1
ENST00000439216.1
ENST00000371571.4
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr19_+_41117770 0.15 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr19_-_11639910 0.14 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chrX_+_115567767 0.13 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr19_-_11639931 0.11 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr10_+_88728189 0.10 ENST00000416348.1
ADIRF
adipogenesis regulatory factor
chr1_+_6511651 0.10 ENST00000434576.1
ESPN
espin
chr22_-_39636914 0.09 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr15_+_66797627 0.09 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chr20_-_49639612 0.09 ENST00000396017.3
ENST00000433903.1
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr14_-_24732738 0.09 ENST00000558074.1
ENST00000560226.1
TGM1
transglutaminase 1
chr22_+_38864041 0.08 ENST00000216014.4
ENST00000409006.3
KDELR3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr1_+_172502244 0.08 ENST00000610051.1
SUCO
SUN domain containing ossification factor
chr3_-_169381166 0.07 ENST00000486748.1
MECOM
MDS1 and EVI1 complex locus
chr6_+_26045603 0.07 ENST00000540144.1
HIST1H3C
histone cluster 1, H3c
chr20_+_62697564 0.07 ENST00000458442.1
TCEA2
transcription elongation factor A (SII), 2
chr4_+_667307 0.07 ENST00000506838.1
MYL5
myosin, light chain 5, regulatory
chr2_+_219264762 0.05 ENST00000452977.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr6_-_32160622 0.05 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr7_+_143078652 0.05 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr6_-_24721054 0.05 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr1_+_54359854 0.05 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chrX_-_73072534 0.05 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr2_+_234296792 0.04 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr5_+_159343688 0.04 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr2_+_219264466 0.04 ENST00000273062.2
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr15_+_74287035 0.04 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr7_+_143079000 0.04 ENST00000392910.2
ZYX
zyxin
chr5_+_80256453 0.04 ENST00000265080.4
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr19_+_50180317 0.04 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr11_-_441964 0.04 ENST00000332826.6
ANO9
anoctamin 9
chr1_+_172502336 0.04 ENST00000263688.3
SUCO
SUN domain containing ossification factor
chr19_+_42724423 0.04 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr5_+_102455968 0.03 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr4_-_83295296 0.03 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr14_+_24025345 0.03 ENST00000557630.1
THTPA
thiamine triphosphatase
chr2_-_179343268 0.03 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr9_+_139560197 0.02 ENST00000371698.3
EGFL7
EGF-like-domain, multiple 7
chr5_+_145317356 0.02 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr5_-_180688105 0.02 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr4_+_667686 0.02 ENST00000505477.1
MYL5
myosin, light chain 5, regulatory
chr12_+_69979446 0.02 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr19_-_49371711 0.02 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr1_-_161168834 0.02 ENST00000367995.3
ENST00000367996.5
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr8_+_81397846 0.02 ENST00000379091.4
ZBTB10
zinc finger and BTB domain containing 10
chr20_-_61569296 0.02 ENST00000370371.4
DIDO1
death inducer-obliterator 1
chr5_+_102455853 0.02 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr4_-_83295103 0.02 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr15_-_66797172 0.02 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr9_+_17135016 0.02 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr11_+_47279504 0.02 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr8_+_94712732 0.02 ENST00000518322.1
FAM92A1
family with sequence similarity 92, member A1
chr14_+_32030582 0.01 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr19_-_35264089 0.01 ENST00000588760.1
ENST00000329285.8
ENST00000587354.2
ZNF599
zinc finger protein 599
chr16_+_29823552 0.00 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr1_-_35497283 0.00 ENST00000373333.1
ZMYM6
zinc finger, MYM-type 6
chr11_-_40314652 0.00 ENST00000527150.1
LRRC4C
leucine rich repeat containing 4C
chr20_+_30555805 0.00 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr16_+_15068831 0.00 ENST00000535621.2
ENST00000566426.1
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr16_+_29674540 0.00 ENST00000436527.1
ENST00000360121.3
ENST00000449759.1
SPN
QPRT
sialophorin
quinolinate phosphoribosyltransferase
chr5_-_102455801 0.00 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1905176 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.0 GO:1990828 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.0 0.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.1 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.0 GO:0010360 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0072719 cellular response to cisplatin(GO:0072719) regulation of response to drug(GO:2001023)
0.0 0.1 GO:0030046 parallel actin filament bundle assembly(GO:0030046)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)