ISMARA results: PPARG

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARG

Z-value: 0.90

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Transcription factors associated with PPARG

Gene Symbol	Gene ID	Gene Info
PPARG Ensembl NCBI GeneCards UniProt NextProt	ENSG00000132170.15	peroxisome proliferator activated receptor gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PPARG	hg19_v2_chr3_+_12329397_12329433	-0.71	1.1e-01	Click!

Activity profile of PPARG motif

Sorted Z-values of PPARG motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_153433120 Show fit	0.83	ENST00000368723.3	S100A7 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A7
chr19_+_49661037 Show fit	0.77	ENST00000427978.2	TRPM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transient receptor potential cation channel, subfamily M, member 4
chr19_-_1592828 Show fit	0.74	ENST00000592012.1	MBD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	methyl-CpG binding domain protein 3
chr5_+_131409476 Show fit	0.71	ENST00000296871.2	CSF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 2 (granulocyte-macrophage)
chr5_-_150460539 Show fit	0.64	ENST00000520931.1 ENST00000520695.1 ENST00000521591.1 ENST00000518977.1	TNIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TNFAIP3 interacting protein 1
chr19_+_49660997 Show fit	0.53	ENST00000598691.1 ENST00000252826.5	TRPM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transient receptor potential cation channel, subfamily M, member 4
chr19_+_49661079 Show fit	0.52	ENST00000355712.5	TRPM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transient receptor potential cation channel, subfamily M, member 4
chr8_-_10336885 Show fit	0.45	ENST00000520494.1	RP11-981G7.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-981G7.3
chr4_+_57371509 Show fit	0.44	ENST00000360096.2	ARL9 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADP-ribosylation factor-like 9
chr14_+_24630465 Show fit	0.44	ENST00000557894.1 ENST00000559284.1 ENST00000560275.1	IRF9 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon regulatory factor 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.8	GO:1990736	positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.0	1.0	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.1	0.8	GO:0010820	positive regulation of T cell chemotaxis(GO:0010820)
0.0	0.8	GO:0007620	copulation(GO:0007620)
0.2	0.7	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.2	0.7	GO:0034224	cellular response to zinc ion starvation(GO:0034224)
0.1	0.6	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.1	0.6	GO:0052027	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0	0.6	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	0.5	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)

Showing 1 to 10 of 79 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0034706	sodium channel complex(GO:0034706)
0.0	1.1	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.4	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.3	GO:0033263	CORVET complex(GO:0033263)
0.1	0.2	GO:0036025	protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0	0.2	GO:0097513	myosin II filament(GO:0097513)
0.0	0.2	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.2	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.2	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	1.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.8	GO:0050786	RAGE receptor binding(GO:0050786)
0.1	0.6	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.6	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	0.5	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.4	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	0.4	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0	0.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.3	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)

Showing 1 to 10 of 53 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.4	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.8	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.5	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels

Showing 1 to 5 of 5 entries

Results for PPARG

Z-value: 0.90

Motif logo

Transcription factors associated with PPARG

Activity-expression correlation:

Activity profile of PPARG motif

Sorted Z-values of PPARG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: