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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARD

Z-value: 0.39

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310391_353104100.128.1e-01Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_172484377 0.34 ENST00000523161.1
CREBRF
CREB3 regulatory factor
chrX_-_108868390 0.24 ENST00000372101.2
KCNE1L
KCNE1-like
chr1_+_6511651 0.17 ENST00000434576.1
ESPN
espin
chr7_-_34978980 0.17 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chr11_+_66624527 0.17 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_111169565 0.16 ENST00000528846.1
COLCA2
colorectal cancer associated 2
chr15_+_82555125 0.15 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B
family with sequence similarity 154, member B
chr14_+_32546145 0.14 ENST00000556611.1
ENST00000539826.2
ARHGAP5
Rho GTPase activating protein 5
chr2_+_159651821 0.14 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr12_+_121163602 0.13 ENST00000411593.2
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr12_+_121163538 0.13 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr6_+_33172407 0.12 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr2_+_228190066 0.12 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr17_+_48610074 0.12 ENST00000503690.1
ENST00000514874.1
ENST00000537145.1
ENST00000541226.1
EPN3
epsin 3
chr4_+_159593418 0.11 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr14_+_32546274 0.11 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr14_+_74551650 0.11 ENST00000554938.1
LIN52
lin-52 homolog (C. elegans)
chr3_+_48507210 0.10 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr17_+_7123207 0.10 ENST00000584103.1
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase, very long chain
chr12_-_109797249 0.09 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr2_-_28113217 0.08 ENST00000444339.2
RBKS
ribokinase
chr11_+_111169976 0.08 ENST00000398035.2
COLCA2
colorectal cancer associated 2
chr4_+_159593271 0.08 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr2_+_198365122 0.08 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_-_45939374 0.08 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chr2_+_178257372 0.08 ENST00000264167.4
ENST00000409888.1
AGPS
alkylglycerone phosphate synthase
chr2_+_219433588 0.08 ENST00000295701.5
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr1_+_202317815 0.07 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr10_+_94050913 0.07 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr2_-_178257401 0.07 ENST00000464747.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr12_-_95467267 0.07 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr5_-_16509101 0.07 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr3_-_50605077 0.07 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr9_+_131901661 0.06 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr19_-_49339080 0.05 ENST00000595764.1
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr1_+_244998602 0.05 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr5_+_14664762 0.05 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr17_-_4464081 0.05 ENST00000574154.1
GGT6
gamma-glutamyltransferase 6
chr12_-_56727676 0.05 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_+_115142217 0.05 ENST00000398805.3
ENST00000398803.1
ENST00000262542.7
ENST00000539114.1
HSDL2
hydroxysteroid dehydrogenase like 2
chr6_+_143999072 0.05 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2
phosphatase and actin regulator 2
chr1_+_156123318 0.05 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr8_-_116681686 0.04 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr3_-_49314640 0.04 ENST00000436325.1
C3orf62
chromosome 3 open reading frame 62
chr8_+_145065705 0.04 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr2_-_99871570 0.04 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr6_+_88299833 0.04 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr10_-_94050820 0.04 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr2_+_219283815 0.04 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr17_+_4802713 0.04 ENST00000521575.1
ENST00000381365.3
C17orf107
chromosome 17 open reading frame 107
chr9_+_35042205 0.04 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr20_-_44485835 0.04 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr4_+_174089904 0.04 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr19_-_3062465 0.04 ENST00000327141.4
AES
amino-terminal enhancer of split
chr6_+_142468383 0.03 ENST00000367621.1
ENST00000452973.2
VTA1
vesicle (multivesicular body) trafficking 1
chr17_+_48610042 0.03 ENST00000503246.1
EPN3
epsin 3
chr8_+_145065521 0.03 ENST00000534791.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr11_+_17281900 0.03 ENST00000530527.1
NUCB2
nucleobindin 2
chr3_+_186383741 0.03 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr12_-_6665200 0.03 ENST00000336604.4
ENST00000396840.2
ENST00000356896.4
IFFO1
intermediate filament family orphan 1
chr4_-_108204904 0.03 ENST00000510463.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr2_+_219433281 0.03 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr15_-_43865633 0.03 ENST00000437065.1
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr20_+_46130601 0.03 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr19_+_29493456 0.02 ENST00000591143.1
ENST00000592653.1
CTD-2081K17.2
CTD-2081K17.2
chr15_+_82555169 0.02 ENST00000565432.1
ENST00000427381.2
FAM154B
family with sequence similarity 154, member B
chr2_+_95940186 0.02 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr4_-_108204846 0.02 ENST00000513208.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr20_+_42187682 0.02 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_19870167 0.02 ENST00000440354.2
RIN2
Ras and Rab interactor 2
chr1_+_202317855 0.02 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr1_-_160253998 0.02 ENST00000392220.2
PEX19
peroxisomal biogenesis factor 19
chr2_+_39117010 0.02 ENST00000409978.1
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr12_-_109219937 0.02 ENST00000546697.1
SSH1
slingshot protein phosphatase 1
chr15_+_43885252 0.01 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr20_+_32077880 0.01 ENST00000342704.6
ENST00000375279.2
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr16_-_75285380 0.01 ENST00000393420.6
ENST00000162330.5
BCAR1
breast cancer anti-estrogen resistance 1
chr1_+_62417957 0.01 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr21_+_27107672 0.01 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr2_+_120125245 0.01 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr16_+_2255841 0.01 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr15_+_91449971 0.01 ENST00000557865.1
MAN2A2
mannosidase, alpha, class 2A, member 2
chr12_-_53320245 0.01 ENST00000552150.1
KRT8
keratin 8
chr1_-_11863171 0.01 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr6_+_142468361 0.01 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr20_+_42187608 0.01 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr7_+_7222233 0.01 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr7_+_100663353 0.01 ENST00000306151.4
MUC17
mucin 17, cell surface associated
chr15_-_82555000 0.01 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
EFTUD1
elongation factor Tu GTP binding domain containing 1
chr1_-_11107280 0.01 ENST00000400897.3
ENST00000400898.3
MASP2
mannan-binding lectin serine peptidase 2
chr15_+_43985084 0.01 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr12_-_56727487 0.01 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr1_-_161102367 0.01 ENST00000464113.1
DEDD
death effector domain containing
chr12_+_96252706 0.01 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_+_7222157 0.01 ENST00000419721.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr2_-_219433014 0.01 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr2_-_198364581 0.01 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr11_-_47470682 0.01 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr8_-_80942467 0.01 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr11_-_47470591 0.01 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr11_-_119599794 0.00 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr6_+_143999185 0.00 ENST00000542769.1
ENST00000397980.3
PHACTR2
phosphatase and actin regulator 2
chr5_-_143550159 0.00 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr21_-_27107881 0.00 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr6_+_31637944 0.00 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr16_+_81272287 0.00 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr21_-_27107283 0.00 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr19_+_10197463 0.00 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr1_-_29508321 0.00 ENST00000546138.1
SRSF4
serine/arginine-rich splicing factor 4
chr3_-_125094093 0.00 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr6_-_33547975 0.00 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr22_-_29784519 0.00 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr11_-_45939565 0.00 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr6_-_88299678 0.00 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr11_-_47470703 0.00 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.2 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.1 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0046223 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation