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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU4F2

Z-value: 0.48

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_1475600460.824.7e-02Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_134914673 0.60 ENST00000512158.1
CXCL14
chemokine (C-X-C motif) ligand 14
chr4_+_141264597 0.40 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr8_+_97773202 0.31 ENST00000519484.1
CPQ
carboxypeptidase Q
chr4_+_104346194 0.28 ENST00000510200.1
RP11-328K4.1
RP11-328K4.1
chrX_+_3189861 0.25 ENST00000457435.1
ENST00000420429.2
CXorf28
chromosome X open reading frame 28
chr2_+_17997763 0.24 ENST00000281047.3
MSGN1
mesogenin 1
chr3_+_121774202 0.23 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr5_+_102200948 0.23 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr8_+_97773457 0.21 ENST00000521142.1
CPQ
carboxypeptidase Q
chr20_+_5987890 0.21 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr10_-_116444371 0.19 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr1_+_193028717 0.19 ENST00000415442.2
ENST00000506303.1
TROVE2
TROVE domain family, member 2
chr12_-_118796910 0.19 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr13_-_36050819 0.17 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr20_+_48909240 0.17 ENST00000371639.3
RP11-290F20.1
RP11-290F20.1
chr4_+_169013666 0.16 ENST00000359299.3
ANXA10
annexin A10
chr6_-_111804905 0.16 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr8_-_18541603 0.15 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr14_-_51027838 0.15 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_-_118796971 0.15 ENST00000542902.1
TAOK3
TAO kinase 3
chr6_-_111136513 0.14 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr4_-_36245561 0.13 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_5830768 0.13 ENST00000381506.3
ERMP1
endoplasmic reticulum metallopeptidase 1
chr17_+_61151306 0.13 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr12_+_64798826 0.12 ENST00000540203.1
XPOT
exportin, tRNA
chr1_+_193028552 0.12 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr1_-_193028621 0.12 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr1_-_204183071 0.12 ENST00000308302.3
GOLT1A
golgi transport 1A
chr6_-_111136299 0.11 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr11_+_31531291 0.09 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chrX_+_68835911 0.09 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr3_+_147657764 0.09 ENST00000467198.1
ENST00000485006.1
RP11-71N10.1
RP11-71N10.1
chr1_-_193028426 0.09 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr19_-_38344165 0.09 ENST00000592714.1
ENST00000587395.1
AC016582.2
AC016582.2
chr12_+_109577202 0.08 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr11_-_96076334 0.08 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr13_-_34250861 0.08 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr1_+_160370344 0.07 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr1_-_193028632 0.07 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr2_+_172309634 0.07 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr9_+_125133315 0.07 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_49834299 0.06 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr4_-_47983519 0.06 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr14_-_70883708 0.06 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr2_+_191792376 0.06 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr16_+_89228757 0.06 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr6_+_151042224 0.06 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr7_+_142982023 0.05 ENST00000359333.3
ENST00000409244.1
ENST00000409541.1
ENST00000410004.1
TMEM139
transmembrane protein 139
chr17_-_33390667 0.05 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr11_-_795170 0.05 ENST00000481290.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr5_-_87516448 0.05 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr1_+_198608146 0.04 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_-_98417780 0.04 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr9_+_125132803 0.04 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_144354644 0.04 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr16_+_28505955 0.04 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
APOBR
apolipoprotein B receptor
chr17_+_48243352 0.03 ENST00000344627.6
ENST00000262018.3
ENST00000543315.1
ENST00000451235.2
ENST00000511303.1
SGCA
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
chr16_+_19422035 0.03 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr11_-_107729504 0.03 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr14_-_90085458 0.03 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr10_+_123951957 0.03 ENST00000514539.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_138820624 0.03 ENST00000343505.5
NHSL1
NHS-like 1
chr16_+_19421803 0.03 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr15_-_37393406 0.03 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr2_+_44502597 0.03 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr14_+_32030582 0.03 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr15_-_74421477 0.03 ENST00000514871.1
RP11-247C2.2
HCG2004779; Uncharacterized protein
chr18_+_74240610 0.03 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr4_-_169401628 0.03 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr2_-_122262593 0.03 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chr12_-_118797475 0.03 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr6_+_12717892 0.02 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr9_+_12685439 0.02 ENST00000473763.1
TYRP1
tyrosinase-related protein 1
chr11_-_107729887 0.02 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr8_-_49833978 0.02 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr2_-_158300556 0.02 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr6_+_39760129 0.02 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr10_+_99205959 0.02 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr13_+_36050881 0.02 ENST00000537702.1
NBEA
neurobeachin
chrX_-_133931164 0.02 ENST00000370790.1
ENST00000298090.6
FAM122B
family with sequence similarity 122B
chr12_-_89746173 0.02 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr9_+_125133467 0.02 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_-_10446449 0.01 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr10_-_21186144 0.01 ENST00000377119.1
NEBL
nebulette
chrX_-_99987088 0.01 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr3_-_58613323 0.01 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr18_+_28898052 0.01 ENST00000257192.4
DSG1
desmoglein 1
chr13_+_46039037 0.01 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr2_-_70780572 0.01 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr12_-_7596735 0.01 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1
chr6_+_130339710 0.01 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr20_-_50418972 0.01 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr17_-_39623681 0.00 ENST00000225899.3
KRT32
keratin 32
chr4_+_169418195 0.00 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr10_+_99205894 0.00 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.2 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.3 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.1 0.5 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.6 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG