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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU3F2
Z-value: 1.89
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | 0.65 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_124824000 Show fit | 1.26 |
ENST00000529051.1
ENST00000344762.5 |
coiled-coil domain containing 15 |
|
| chr6_+_71104588 Show fit | 1.14 |
ENST00000418403.1
|
RP11-462G2.1 |
|
| chr7_-_35013217 Show fit | 1.08 |
ENST00000446375.1
|
dpy-19-like 1 (C. elegans) |
|
| chr8_+_74903580 Show fit | 1.06 |
ENST00000284818.2
ENST00000518893.1 |
lymphocyte antigen 96 |
|
| chr3_+_111697843 Show fit | 1.01 |
ENST00000534857.1
ENST00000273359.3 ENST00000494817.1 |
abhydrolase domain containing 10 |
|
| chr6_-_113953705 Show fit | 0.96 |
ENST00000452675.1
|
RP11-367G18.1 |
|
| chr2_-_188312971 Show fit | 0.90 |
ENST00000410068.1
ENST00000447403.1 ENST00000410102.1 |
calcitonin receptor-like |
|
| chr8_+_97597148 Show fit | 0.89 |
ENST00000521590.1
|
syndecan 2 |
|
| chr9_+_131684027 Show fit | 0.88 |
ENST00000426694.1
|
phytanoyl-CoA dioxygenase domain containing 1 |
|
| chr1_+_78470530 Show fit | 0.87 |
ENST00000370763.5
|
DnaJ (Hsp40) homolog, subfamily B, member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0018317 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 1.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 1.5 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.2 | 1.4 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 1.4 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.2 | GO:0042737 | drug catabolic process(GO:0042737) |
| 0.3 | 1.1 | GO:0042231 | interleukin-13 biosynthetic process(GO:0042231) |
| 0.2 | 1.1 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) detection of lipopolysaccharide(GO:0032497) |
| 0.0 | 1.1 | GO:0009452 | 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 1.6 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 1.3 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.2 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 1.2 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 1.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 1.3 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.2 | 1.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.0 | 1.2 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.2 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 1.1 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 0.1 | 1.1 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 1.1 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 1.1 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 1.2 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 1.2 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 1.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.2 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.1 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |