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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU2F2_POU3F1
Z-value: 1.21
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636543_42636607 | 0.42 | 4.1e-01 | Click! |
| POU3F1 | hg19_v2_chr1_-_38512450_38512474 | -0.06 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_26251835 Show fit | 2.00 |
ENST00000356350.2
|
histone cluster 1, H2bh |
|
| chr17_+_38171681 Show fit | 1.90 |
ENST00000225474.2
ENST00000331769.2 ENST00000394148.3 ENST00000577675.1 |
colony stimulating factor 3 (granulocyte) |
|
| chr17_+_38171614 Show fit | 1.71 |
ENST00000583218.1
ENST00000394149.3 |
colony stimulating factor 3 (granulocyte) |
|
| chr2_+_89952792 Show fit | 1.20 |
ENST00000390265.2
|
immunoglobulin kappa variable 1D-33 |
|
| chr1_+_149822620 Show fit | 1.17 |
ENST00000369159.2
|
histone cluster 2, H2aa4 |
|
| chr9_+_136325089 Show fit | 1.01 |
ENST00000291722.7
ENST00000316948.4 ENST00000540581.1 |
calcium channel flower domain containing 1 |
|
| chr1_-_153044083 Show fit | 0.99 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr6_-_27860956 Show fit | 0.97 |
ENST00000359611.2
|
histone cluster 1, H2am |
|
| chr1_-_149814478 Show fit | 0.92 |
ENST00000369161.3
|
histone cluster 2, H2aa3 |
|
| chr6_+_27861190 Show fit | 0.85 |
ENST00000303806.4
|
histone cluster 1, H2bo |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.6 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.0 | 3.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.4 | 1.8 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.1 | 1.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 1.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 1.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 1.0 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 1.0 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.3 | 0.8 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.3 | 0.8 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.6 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.4 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 0.4 | GO:0036128 | CatSper complex(GO:0036128) meiotic spindle(GO:0072687) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.0 | 1.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 1.0 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 1.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 0.7 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 0.6 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 0.6 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.0 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.4 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |