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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PLAGL1
Z-value: 4.00
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144329384_144329405 | 0.38 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_65686952 Show fit | 3.41 |
ENST00000527119.1
|
DR1-associated protein 1 (negative cofactor 2 alpha) |
|
| chr17_-_79304150 Show fit | 2.91 |
ENST00000574093.1
|
transmembrane protein 105 |
|
| chr2_+_74212073 Show fit | 2.65 |
ENST00000441217.1
|
AC073046.25 |
|
| chr11_-_795400 Show fit | 2.55 |
ENST00000526152.1
ENST00000456706.2 ENST00000528936.1 |
solute carrier family 25 (mitochondrial carrier: glutamate), member 22 |
|
| chr11_+_64052692 Show fit | 2.46 |
ENST00000377702.4
|
G protein-coupled receptor 137 |
|
| chr11_+_66624527 Show fit | 2.43 |
ENST00000393952.3
|
leucine rich repeat and fibronectin type III domain containing 4 |
|
| chr19_-_50990785 Show fit | 2.42 |
ENST00000595005.1
|
CTD-2545M3.8 |
|
| chr19_-_1592652 Show fit | 2.39 |
ENST00000156825.1
ENST00000434436.3 |
methyl-CpG binding domain protein 3 |
|
| chr19_+_54372877 Show fit | 2.34 |
ENST00000414489.1
|
myeloid-associated differentiation marker |
|
| chr17_+_27895609 Show fit | 2.31 |
ENST00000581411.2
ENST00000301057.7 |
tumor protein p53 inducible protein 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0006414 | translational elongation(GO:0006414) |
| 0.2 | 6.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 5.8 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.7 | 5.5 | GO:0043585 | nose morphogenesis(GO:0043585) |
| 0.2 | 5.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 5.2 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 4.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.1 | 4.3 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.4 | 4.3 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 4.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 22.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 14.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 11.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 11.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 10.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 6.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 6.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.2 | 5.2 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 8.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 6.9 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.2 | 6.8 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.2 | 6.8 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 6.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 6.1 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.6 | 5.9 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 10.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 8.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 7.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 6.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 6.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 5.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 5.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 11.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 7.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 6.8 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 6.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 6.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 5.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 5.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 5.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |