ISMARA results: PITX3

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX3

Z-value: 1.48

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Transcription factors associated with PITX3

Gene Symbol	Gene ID	Gene Info
PITX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000107859.5	paired like homeodomain 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PITX3	hg19_v2_chr10_-_104001231_104001274	0.21	7.0e-01	Click!

Activity profile of PITX3 motif

Sorted Z-values of PITX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_153013588 Show fit	2.14	ENST00000360379.3	SPRR2D Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2D
chr15_-_80263506 Show fit	1.13	ENST00000335661.6	BCL2A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	BCL2-related protein A1
chr12_+_22852791 Show fit	0.99	ENST00000413794.2	RP11-114G22.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-114G22.1
chr17_-_38859996 Show fit	0.88	ENST00000264651.2	KRT24 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 24
chr6_-_10694766 Show fit	0.84	ENST00000460742.2 ENST00000259983.3 ENST00000379586.1	C6orf52 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 6 open reading frame 52
chr1_-_153363452 Show fit	0.83	ENST00000368732.1 ENST00000368733.3	S100A8 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A8
chr1_-_153113927 Show fit	0.79	ENST00000368752.4	SPRR2B Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2B
chr19_-_6690723 Show fit	0.79	ENST00000601008.1	C3 Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 3
chr8_-_25281747 Show fit	0.77	ENST00000421054.2	GNRH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr8_-_150563 Show fit	0.72	ENST00000523795.2	RP11-585F1.10 Ensembl NCBI GeneCards UniProt NextProt Show fit	Protein LOC100286914

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0018149	peptide cross-linking(GO:0018149)
0.0	1.3	GO:0048246	macrophage chemotaxis(GO:0048246)
0.0	1.2	GO:0050962	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	1.2	GO:0008053	mitochondrial fusion(GO:0008053)
0.1	0.9	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.9	GO:0035455	response to interferon-alpha(GO:0035455)
0.3	0.8	GO:0001798	positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2	0.8	GO:1990637	response to prolactin(GO:1990637)
0.1	0.8	GO:0018377	protein myristoylation(GO:0018377)
0.2	0.7	GO:0030450	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)

Showing 1 to 10 of 327 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:0001533	cornified envelope(GO:0001533)
0.0	1.7	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	1.1	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.1	0.8	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0	0.8	GO:0042627	chylomicron(GO:0042627)
0.0	0.7	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.7	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	0.6	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.6	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.1	0.5	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)

Showing 1 to 10 of 112 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0051400	BH domain binding(GO:0051400)
0.0	1.0	GO:0042056	chemoattractant activity(GO:0042056)
0.0	1.0	GO:0005179	hormone activity(GO:0005179)
0.1	0.8	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	0.7	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.7	GO:0031369	translation initiation factor binding(GO:0031369)
0.2	0.6	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.1	0.6	GO:0004874	aryl hydrocarbon receptor activity(GO:0004874)
0.1	0.6	GO:0017159	pantetheine hydrolase activity(GO:0017159)

Showing 1 to 10 of 225 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
2.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.7	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.6	PID CONE PATHWAY	Visual signal transduction: Cones
0.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	1.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	1.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.9	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.8	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	0.7	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 10 of 42 entries

Results for PITX3

Z-value: 1.48

Motif logo

Transcription factors associated with PITX3

Activity-expression correlation:

Activity profile of PITX3 motif

Sorted Z-values of PITX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: