ISMARA results: PITX1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX1

Z-value: 2.21

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Transcription factors associated with PITX1

Gene Symbol	Gene ID	Gene Info
PITX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000069011.11	paired like homeodomain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PITX1	hg19_v2_chr5_-_134369973_134369988	0.13	8.1e-01	Click!

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_46531127 Show fit	2.18	ENST00000601033.1	CTC-344H19.4 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTC-344H19.4
chr14_-_90097910 Show fit	1.76	ENST00000550332.2	RP11-944C7.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Protein LOC100506792
chr17_+_7253667 Show fit	1.59	ENST00000570504.1 ENST00000574499.1	ACAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr3_-_182881595 Show fit	1.55	ENST00000476015.1	LAMP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	lysosomal-associated membrane protein 3
chr5_+_131409476 Show fit	1.50	ENST00000296871.2	CSF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 2 (granulocyte-macrophage)
chr19_+_7745708 Show fit	1.34	ENST00000596148.1 ENST00000317378.5 ENST00000426877.2	TRAPPC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	trafficking protein particle complex 5
chr4_+_57371509 Show fit	1.33	ENST00000360096.2	ARL9 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADP-ribosylation factor-like 9
chr19_-_50990785 Show fit	1.28	ENST00000595005.1	CTD-2545M3.8 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2545M3.8
chr16_+_47496023 Show fit	1.23	ENST00000567200.1	PHKB Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphorylase kinase, beta
chr11_-_65314905 Show fit	1.21	ENST00000527339.1	LTBP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	latent transforming growth factor beta binding protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.6	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	2.5	GO:0050716	positive regulation of interleukin-1 secretion(GO:0050716)
0.1	2.1	GO:0007567	parturition(GO:0007567)
0.0	2.0	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	2.0	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2	1.7	GO:0038195	urokinase plasminogen activator signaling pathway(GO:0038195)
0.5	1.5	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.1	1.4	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	1.4	GO:0009251	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1	1.3	GO:0010968	regulation of microtubule nucleation(GO:0010968)

Showing 1 to 10 of 382 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0055038	recycling endosome membrane(GO:0055038)
0.6	2.3	GO:0097232	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1	2.2	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	1.7	GO:0071438	invadopodium membrane(GO:0071438)
0.1	1.6	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	1.6	GO:0000313	organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1	1.5	GO:0000243	commitment complex(GO:0000243)
0.1	1.5	GO:0000813	ESCRT I complex(GO:0000813)
0.1	1.5	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1	1.4	GO:0005964	phosphorylase kinase complex(GO:0005964)

Showing 1 to 10 of 143 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0070851	growth factor receptor binding(GO:0070851)
0.0	2.2	GO:0043130	ubiquitin binding(GO:0043130)
0.1	1.8	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.2	1.7	GO:0030377	urokinase plasminogen activator receptor activity(GO:0030377)
0.1	1.7	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	1.7	GO:0042056	chemoattractant activity(GO:0042056)
0.0	1.6	GO:0070034	telomerase RNA binding(GO:0070034)
0.2	1.4	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	1.4	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	1.4	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Showing 1 to 10 of 240 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	3.1	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.7	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.4	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	3.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.7	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	1.5	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	1.5	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	1.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.4	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.1	1.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	1.2	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Showing 1 to 10 of 69 entries

Results for PITX1

Z-value: 2.21

Motif logo

Transcription factors associated with PITX1

Activity-expression correlation:

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: