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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PGR
Z-value: 0.49
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Transcription factors associated with PGR
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_22766766 Show fit | 0.55 |
ENST00000426291.1
ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1 |
interleukin 6 (interferon, beta 2) |
|
| chr3_+_52454971 Show fit | 0.39 |
ENST00000465863.1
|
PHD finger protein 7 |
|
| chr7_-_75241096 Show fit | 0.27 |
ENST00000420909.1
|
huntingtin interacting protein 1 |
|
| chr17_+_67590125 Show fit | 0.24 |
ENST00000591334.1
|
AC003051.1 |
|
| chr5_+_148443049 Show fit | 0.22 |
ENST00000515304.1
ENST00000507318.1 |
CTC-529P8.1 |
|
| chr17_+_46970134 Show fit | 0.22 |
ENST00000503641.1
ENST00000514808.1 |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
|
| chr15_+_31658349 Show fit | 0.21 |
ENST00000558844.1
|
Kruppel-like factor 13 |
|
| chr6_+_30951487 Show fit | 0.21 |
ENST00000486149.2
ENST00000376296.3 |
mucin 21, cell surface associated |
|
| chr17_-_7760457 Show fit | 0.18 |
ENST00000576384.1
|
LSM domain containing 1 |
|
| chr16_+_58497274 Show fit | 0.18 |
ENST00000564207.1
|
NDRG family member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PGR
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.0 | 0.5 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 0.3 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.1 | 0.3 | GO:2000588 | positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588) |
| 0.0 | 0.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.0 | 0.2 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.0 | 0.2 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 0.2 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.0 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.1 | GO:0003275 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) glomerular endothelium development(GO:0072011) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.3 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.1 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.0 | 0.1 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.1 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 0.1 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.1 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 0.2 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.0 | 0.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 0.1 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.0 | 0.1 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.0 | 0.1 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.1 | GO:0015229 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.0 | 0.1 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.5 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |