ISMARA results: PBX3

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PBX3

Z-value: 1.64

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Transcription factors associated with PBX3

Gene Symbol	Gene ID	Gene Info
PBX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000167081.12	PBX homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PBX3	hg19_v2_chr9_+_128509624_128509658	0.72	1.0e-01	Click!

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_26859300 Show fit	1.24	ENST00000494628.2	STIM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	stromal interaction molecule 2
chr12_+_65996599 Show fit	1.07	ENST00000539116.1 ENST00000541391.1	RP11-221N13.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-221N13.3
chr7_-_64023441 Show fit	1.00	ENST00000309683.6	ZNF680 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 680
chr11_-_73720276 Show fit	0.97	ENST00000348534.4	UCP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	uncoupling protein 3 (mitochondrial, proton carrier)
chr4_-_87515202 Show fit	0.95	ENST00000502302.1 ENST00000513186.1	MAPK10 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitogen-activated protein kinase 10
chr2_-_61765315 Show fit	0.95	ENST00000406957.1 ENST00000401558.2	XPO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	exportin 1 (CRM1 homolog, yeast)
chr6_+_63921351 Show fit	0.92	ENST00000370659.1	FKBP1C Ensembl NCBI GeneCards UniProt NextProt Show fit	FK506 binding protein 1C
chr20_+_52824367 Show fit	0.89	ENST00000371419.2	PFDN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	prefoldin subunit 4
chr19_+_21324827 Show fit	0.85	ENST00000600692.1 ENST00000599296.1 ENST00000594425.1 ENST00000311048.7	ZNF431 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 431
chr19_+_21688366 Show fit	0.82	ENST00000358491.4 ENST00000597078.1	ZNF429 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 429

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.7	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	1.5	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.1	1.4	GO:1990845	adaptive thermogenesis(GO:1990845)
0.3	1.2	GO:0061290	cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1	1.2	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	1.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	1.0	GO:0090168	Golgi reassembly(GO:0090168)
0.0	1.0	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.1	0.8	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.1	0.8	GO:2001300	lipoxin metabolic process(GO:2001300)

Showing 1 to 10 of 115 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	GO:0005642	annulate lamellae(GO:0005642)
0.1	1.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	0.9	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.7	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	0.5	GO:0070695	FHF complex(GO:0070695)
0.0	0.5	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.5	GO:0032039	integrator complex(GO:0032039)
0.0	0.5	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.5	GO:0097440	apical dendrite(GO:0097440)
0.1	0.4	GO:0060187	cell pole(GO:0060187)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	1.5	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2	1.4	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.0	1.3	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	1.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	1.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.9	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2	0.8	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1	0.8	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.1	0.8	GO:0008430	selenium binding(GO:0008430)

Showing 1 to 10 of 72 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	PID FOXO PATHWAY	FoxO family signaling
0.1	1.7	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.2	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.0	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	1.7	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	1.6	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0	1.5	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	1.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.9	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	0.8	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.6	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)

Showing 1 to 10 of 22 entries

Results for PBX3

Z-value: 1.64

Motif logo

Transcription factors associated with PBX3

Activity-expression correlation:

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: