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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PATZ1_KLF4
Z-value: 3.73
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF4 | hg19_v2_chr9_-_110251836_110251927 | -0.62 | 1.9e-01 | Click! |
| PATZ1 | hg19_v2_chr22_-_31742218_31742350 | -0.15 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_54372877 Show fit | 7.70 |
ENST00000414489.1
|
myeloid-associated differentiation marker |
|
| chr1_-_160068645 Show fit | 5.45 |
ENST00000448417.1
|
immunoglobulin superfamily, member 8 |
|
| chr11_+_65686952 Show fit | 5.44 |
ENST00000527119.1
|
DR1-associated protein 1 (negative cofactor 2 alpha) |
|
| chr1_+_37940153 Show fit | 5.25 |
ENST00000373087.6
|
zinc finger CCCH-type containing 12A |
|
| chr19_-_54984354 Show fit | 4.64 |
ENST00000301200.2
|
CDC42 effector protein (Rho GTPase binding) 5 |
|
| chr11_-_67397371 Show fit | 4.49 |
ENST00000376693.2
ENST00000301490.4 |
nudix (nucleoside diphosphate linked moiety X)-type motif 8 |
|
| chr19_-_10946949 Show fit | 4.13 |
ENST00000214869.2
ENST00000591695.1 |
transmembrane emp24 protein transport domain containing 1 |
|
| chr22_-_43583079 Show fit | 4.06 |
ENST00000216129.6
|
tubulin tyrosine ligase-like family, member 12 |
|
| chr7_-_1499123 Show fit | 4.06 |
ENST00000297508.7
|
MICAL-like 2 |
|
| chr19_-_48673552 Show fit | 3.92 |
ENST00000536218.1
ENST00000596549.1 |
ligase I, DNA, ATP-dependent |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.0 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.4 | 13.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 12.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 1.4 | 11.5 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.2 | 10.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 10.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 10.6 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 9.7 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.4 | 9.0 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 2.9 | 8.7 | GO:2000656 | regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 90.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 41.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 20.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 16.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 16.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 16.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 15.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 15.1 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 14.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 14.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 33.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 19.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.6 | 19.5 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 14.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 14.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 13.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 13.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.7 | 11.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 11.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 26.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 21.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.5 | 19.0 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.3 | 17.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 13.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 13.2 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 12.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 12.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 12.2 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 16.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 14.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 14.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 14.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 12.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.6 | 12.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.3 | 12.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 12.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 12.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |