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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for OLIG3_NEUROD2_NEUROG2
Z-value: 0.91
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Transcription factors associated with OLIG3_NEUROD2_NEUROG2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177468.5 | oligodendrocyte transcription factor 3 | |
| ENSG00000171532.4 | neuronal differentiation 2 | |
| ENSG00000178403.3 | neurogenin 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NEUROD2 | hg19_v2_chr17_-_37764128_37764258 | -0.49 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_66918558 Show fit | 0.94 |
ENST00000435389.1
ENST00000428590.1 ENST00000412944.1 |
AC007392.3 |
|
| chr19_+_42041860 Show fit | 0.82 |
ENST00000483481.2
ENST00000494375.2 |
AC006129.4 |
|
| chr7_-_41742697 Show fit | 0.64 |
ENST00000242208.4
|
inhibin, beta A |
|
| chr1_+_95975672 Show fit | 0.56 |
ENST00000440116.2
ENST00000456933.1 |
RP11-286B14.1 |
|
| chr15_-_63448973 Show fit | 0.55 |
ENST00000462430.1
|
ribosomal protein S27-like |
|
| chr3_+_172361483 Show fit | 0.55 |
ENST00000598405.1
|
HCG1787166; PRO1163; Uncharacterized protein |
|
| chr4_-_140544386 Show fit | 0.51 |
ENST00000561977.1
|
RP11-308D13.3 |
|
| chr12_-_113658892 Show fit | 0.45 |
ENST00000299732.2
ENST00000416617.2 |
IQ motif containing D |
|
| chr12_+_42624050 Show fit | 0.44 |
ENST00000601185.1
|
Uncharacterized protein |
|
| chr6_-_160147925 Show fit | 0.44 |
ENST00000535561.1
|
superoxide dismutase 2, mitochondrial |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG3_NEUROD2_NEUROG2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.0 | 0.6 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 0.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.5 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.5 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.5 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.1 | 0.4 | GO:0007571 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 0.4 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 0.4 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 0.4 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.1 | 0.6 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 0.6 | GO:0098576 | lumenal side of membrane(GO:0098576) |
| 0.0 | 0.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.3 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.6 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 0.4 | GO:0030272 | 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272) |
| 0.1 | 0.4 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.0 | 0.4 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 0.4 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 0.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.3 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.0 | 0.3 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 0.5 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.4 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.2 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |