ISMARA results: OLIG2_NEUROD1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OLIG2_NEUROD1_ATOH1

Z-value: 0.96

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Transcription factors associated with OLIG2_NEUROD1_ATOH1

Gene Symbol	Gene ID	Gene Info
OLIG2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000205927.4	oligodendrocyte transcription factor 2
NEUROD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162992.3	neuronal differentiation 1
ATOH1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172238.3	atonal bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NEUROD1	hg19_v2_chr2_-_182545603_182545603	-0.78	6.5e-02	Click!
OLIG2	hg19_v2_chr21_+_34398153_34398250	-0.11	8.4e-01	Click!

Activity profile of OLIG2_NEUROD1_ATOH1 motif

Sorted Z-values of OLIG2_NEUROD1_ATOH1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_26250835 Show fit	0.80	ENST00000446824.2	HIST1H3F Ensembl NCBI GeneCards UniProt NextProt Show fit	histone cluster 1, H3f
chr22_-_21905120 Show fit	0.80	ENST00000331505.5	RIMBP3C Ensembl NCBI GeneCards UniProt NextProt Show fit	RIMS binding protein 3C
chr4_-_108204904 Show fit	0.79	ENST00000510463.1	DKK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 2
chr5_-_159766528 Show fit	0.70	ENST00000505287.2	CCNJL Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin J-like
chr12_+_113416340 Show fit	0.63	ENST00000552756.1	OAS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr7_-_41742697 Show fit	0.60	ENST00000242208.4	INHBA Ensembl NCBI GeneCards UniProt NextProt Show fit	inhibin, beta A
chr12_+_113416191 Show fit	0.49	ENST00000342315.4 ENST00000392583.2	OAS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr2_-_7005785 Show fit	0.45	ENST00000256722.5 ENST00000404168.1 ENST00000458098.1	CMPK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_-_19030157 Show fit	0.45	ENST00000349893.4 ENST00000351079.4 ENST00000600932.1 ENST00000262812.4	COPE Ensembl NCBI GeneCards UniProt NextProt Show fit	coatomer protein complex, subunit epsilon
chr12_-_13105081 Show fit	0.43	ENST00000541128.1	GPRC5D Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor, family C, group 5, member D

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG2_NEUROD1_ATOH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0018377	protein myristoylation(GO:0018377)
0.0	0.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	0.6	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0	0.6	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	0.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	0.5	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1	0.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	0.5	GO:0033123	positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0	0.5	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.5	GO:0089711	L-glutamate transmembrane transport(GO:0089711)

Showing 1 to 10 of 86 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0	0.4	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.4	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.3	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.2	GO:0035976	AP1 complex(GO:0035976)
0.0	0.2	GO:0001673	male germ cell nucleus(GO:0001673)
0.0	0.1	GO:0031523	Myb complex(GO:0031523)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3	0.9	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.0	0.7	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	0.7	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1	0.6	GO:0034711	inhibin binding(GO:0034711)
0.1	0.6	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.6	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.6	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	0.5	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	0.5	GO:0009041	uridylate kinase activity(GO:0009041)

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.6	PID ALK1 PATHWAY	ALK1 signaling events
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.9	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.9	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	0.7	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.7	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.4	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane

Showing 1 to 9 of 9 entries

Results for OLIG2_NEUROD1_ATOH1

Z-value: 0.96

Motif logo

Transcription factors associated with OLIG2_NEUROD1_ATOH1

Activity-expression correlation:

Activity profile of OLIG2_NEUROD1_ATOH1 motif

Sorted Z-values of OLIG2_NEUROD1_ATOH1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG2_NEUROD1_ATOH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: