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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR2F2
Z-value: 0.87
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Transcription factors associated with NR2F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2F2 | hg19_v2_chr15_+_96869165_96869183 | 0.59 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_66790146 Show fit | 0.47 |
ENST00000316634.5
|
small nuclear RNA activating complex, polypeptide 5, 19kDa |
|
| chrX_+_122993544 Show fit | 0.40 |
ENST00000422098.1
|
X-linked inhibitor of apoptosis |
|
| chr4_+_57253672 Show fit | 0.38 |
ENST00000602927.1
|
RP11-646I6.5 |
|
| chr18_+_12658209 Show fit | 0.38 |
ENST00000400512.1
|
Uncharacterized protein |
|
| chrX_-_107018969 Show fit | 0.36 |
ENST00000372383.4
|
TSC22 domain family, member 3 |
|
| chr11_+_64053311 Show fit | 0.34 |
ENST00000540370.1
|
G protein-coupled receptor 137 |
|
| chr4_+_184365841 Show fit | 0.32 |
ENST00000510928.1
|
CDKN2A interacting protein |
|
| chr2_+_114163945 Show fit | 0.31 |
ENST00000453673.3
|
immunoglobulin kappa variable 1/OR2-108 (non-functional) |
|
| chr4_-_83483094 Show fit | 0.30 |
ENST00000508701.1
ENST00000454948.3 |
transmembrane protein 150C |
|
| chr1_+_222988363 Show fit | 0.30 |
ENST00000450784.1
ENST00000426045.1 ENST00000457955.1 ENST00000444858.1 ENST00000435378.1 ENST00000441676.1 |
RP11-452F19.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.1 | 0.5 | GO:1902530 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.0 | 0.5 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.1 | 0.4 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.0 | 0.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.0 | 0.4 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 0.3 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.1 | 0.3 | GO:0015993 | molecular hydrogen transport(GO:0015993) |
| 0.1 | 0.3 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.0 | 0.3 | GO:0006108 | malate metabolic process(GO:0006108) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0097196 | Shu complex(GO:0097196) |
| 0.1 | 0.4 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.4 | GO:0001652 | granular component(GO:0001652) |
| 0.0 | 0.4 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.4 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 0.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.1 | 0.2 | GO:0043293 | apoptosome(GO:0043293) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 0.4 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.0 | 0.4 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.4 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.0 | 0.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.4 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 0.3 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
| 0.1 | 0.3 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.0 | 0.3 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 0.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.4 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.4 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.0 | 0.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |