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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1I3

Z-value: 0.35

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Transcription factors associated with NR1I3

Gene Symbol Gene ID Gene Info
NR1I3
ENSG00000143257.7 nuclear receptor subfamily 1 group I member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I3hg19_v2_chr1_-_161207986_1612080000.522.9e-01Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_44007014 0.22 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr5_+_139055055 0.19 ENST00000511457.1
CXXC5
CXXC finger protein 5
chr19_+_2977444 0.18 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
TLE6
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
chr12_+_100594557 0.17 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr5_+_139055021 0.17 ENST00000502716.1
ENST00000503511.1
CXXC5
CXXC finger protein 5
chr1_+_44401479 0.15 ENST00000438616.3
ARTN
artemin
chr19_+_9203855 0.15 ENST00000429566.3
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr14_+_21525981 0.15 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr1_+_154378049 0.14 ENST00000512471.1
IL6R
interleukin 6 receptor
chr5_-_138780159 0.14 ENST00000512473.1
ENST00000515581.1
ENST00000515277.1
DNAJC18
DnaJ (Hsp40) homolog, subfamily C, member 18
chr8_-_53626974 0.14 ENST00000435644.2
ENST00000518710.1
ENST00000025008.5
ENST00000517963.1
RB1CC1
RB1-inducible coiled-coil 1
chr4_+_146402346 0.13 ENST00000514778.1
ENST00000507594.1
SMAD1
SMAD family member 1
chr6_+_96969672 0.13 ENST00000369278.4
UFL1
UFM1-specific ligase 1
chr15_+_96875657 0.13 ENST00000559679.1
ENST00000394171.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_-_46285646 0.12 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr1_+_154377669 0.12 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr15_+_96876340 0.12 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_-_61124266 0.11 ENST00000539890.1
CYB561A3
cytochrome b561 family, member A3
chr19_-_49140692 0.10 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr20_+_5987890 0.10 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr1_+_82165350 0.09 ENST00000359929.3
LPHN2
latrophilin 2
chr19_-_6604094 0.09 ENST00000597430.2
CD70
CD70 molecule
chr7_-_56160625 0.09 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr16_+_67280799 0.08 ENST00000566345.2
SLC9A5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr17_+_62503073 0.08 ENST00000580188.1
ENST00000581056.1
CEP95
centrosomal protein 95kDa
chr18_-_19284724 0.08 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr11_-_82611448 0.08 ENST00000393399.2
ENST00000313010.3
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr16_+_53133070 0.07 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr7_-_56160666 0.07 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr12_-_108991812 0.07 ENST00000392806.3
ENST00000547567.1
TMEM119
transmembrane protein 119
chr1_-_23886285 0.07 ENST00000374561.5
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr17_+_26833250 0.07 ENST00000577936.1
ENST00000579795.1
FOXN1
forkhead box N1
chr4_-_57524061 0.06 ENST00000508121.1
HOPX
HOP homeobox
chr10_-_73848764 0.06 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_-_39270725 0.06 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr3_-_71802760 0.06 ENST00000295612.3
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr2_-_209118974 0.06 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr16_-_16317321 0.05 ENST00000205557.7
ENST00000575728.1
ABCC6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr1_+_26036093 0.05 ENST00000374329.1
MAN1C1
mannosidase, alpha, class 1C, member 1
chr2_-_241075706 0.05 ENST00000607357.1
ENST00000307266.3
MYEOV2
myeloma overexpressed 2
chr2_-_228028829 0.05 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr20_-_45142154 0.05 ENST00000347606.4
ENST00000457685.2
ZNF334
zinc finger protein 334
chr18_-_23671139 0.05 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr19_-_49140609 0.05 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr9_-_80646374 0.05 ENST00000286548.4
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr13_-_114107839 0.05 ENST00000375418.3
ADPRHL1
ADP-ribosylhydrolase like 1
chr7_-_143579973 0.05 ENST00000460532.1
ENST00000491908.1
FAM115A
family with sequence similarity 115, member A
chr16_+_577697 0.04 ENST00000562370.1
ENST00000568988.1
ENST00000219611.2
CAPN15
calpain 15
chr13_-_21635631 0.04 ENST00000382592.4
LATS2
large tumor suppressor kinase 2
chr1_-_20755140 0.04 ENST00000418743.1
ENST00000426428.1
RP4-749H3.1
long intergenic non-protein coding RNA 1141
chr13_+_24883703 0.04 ENST00000332018.4
C1QTNF9
C1q and tumor necrosis factor related protein 9
chr2_-_86790472 0.04 ENST00000409727.1
CHMP3
charged multivesicular body protein 3
chr12_-_118810688 0.04 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr2_-_86790593 0.04 ENST00000263856.4
ENST00000409225.2
CHMP3
charged multivesicular body protein 3
chr1_+_15250596 0.04 ENST00000361144.5
KAZN
kazrin, periplakin interacting protein
chr13_+_60971080 0.04 ENST00000377894.2
TDRD3
tudor domain containing 3
chr6_-_56258892 0.03 ENST00000370819.1
COL21A1
collagen, type XXI, alpha 1
chr4_-_82136114 0.03 ENST00000395578.1
ENST00000418486.2
PRKG2
protein kinase, cGMP-dependent, type II
chr9_+_37486005 0.03 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr9_-_75567962 0.03 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_-_7985193 0.03 ENST00000328600.2
NLRP10
NLR family, pyrin domain containing 10
chr1_-_21625486 0.03 ENST00000481130.2
ECE1
endothelin converting enzyme 1
chr1_+_45274154 0.03 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19
BTB (POZ) domain containing 19
chr20_+_62339381 0.03 ENST00000355969.6
ENST00000357119.4
ENST00000431125.1
ENST00000369967.3
ENST00000328969.5
ZGPAT
zinc finger, CCCH-type with G patch domain
chr11_+_933555 0.03 ENST00000534485.1
AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr17_-_8198636 0.02 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35
solute carrier family 25, member 35
chr4_-_186578674 0.02 ENST00000438278.1
SORBS2
sorbin and SH3 domain containing 2
chr1_-_33336414 0.02 ENST00000373471.3
ENST00000609187.1
FNDC5
fibronectin type III domain containing 5
chr19_+_58920102 0.02 ENST00000599238.1
ENST00000322834.7
ZNF584
zinc finger protein 584
chrX_-_50386648 0.02 ENST00000460112.3
SHROOM4
shroom family member 4
chr17_-_33390667 0.02 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr19_-_7562334 0.02 ENST00000593942.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr22_+_42372764 0.02 ENST00000396426.3
ENST00000406029.1
SEPT3
septin 3
chr15_+_43885252 0.02 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr6_+_71276596 0.02 ENST00000370474.3
C6orf57
chromosome 6 open reading frame 57
chr11_-_71753188 0.02 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr1_+_32930647 0.02 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr12_+_49208234 0.02 ENST00000540990.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr15_+_43985084 0.02 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr7_+_101460882 0.02 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr12_-_54779511 0.02 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chrX_+_118602363 0.02 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr1_-_235116495 0.01 ENST00000549744.1
RP11-443B7.3
RP11-443B7.3
chr22_+_39493268 0.01 ENST00000401756.1
APOBEC3H
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr9_+_35605274 0.01 ENST00000336395.5
TESK1
testis-specific kinase 1
chr1_-_1690014 0.01 ENST00000400922.2
ENST00000342348.5
NADK
NAD kinase
chr1_-_20126365 0.01 ENST00000294543.6
ENST00000375122.2
TMCO4
transmembrane and coiled-coil domains 4
chr9_+_5450503 0.01 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr17_+_32582293 0.01 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr1_+_59250815 0.01 ENST00000544621.1
ENST00000419531.2
RP4-794H19.2
long intergenic non-protein coding RNA 1135
chr1_-_225616515 0.01 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr14_+_53173890 0.01 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr11_-_61124711 0.01 ENST00000536915.1
CYB561A3
cytochrome b561 family, member A3
chr22_+_39493207 0.01 ENST00000348946.4
ENST00000442487.3
ENST00000421988.2
APOBEC3H
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr16_-_4465886 0.01 ENST00000539968.1
CORO7
coronin 7
chr19_+_58919992 0.00 ENST00000306910.4
ENST00000598901.1
ENST00000593920.1
ENST00000596281.1
ZNF584
zinc finger protein 584
chr12_+_53817633 0.00 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
AMHR2
anti-Mullerian hormone receptor, type II
chr17_-_62503015 0.00 ENST00000581806.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr11_-_104480019 0.00 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr11_-_71781096 0.00 ENST00000535087.1
ENST00000535838.1
NUMA1
nuclear mitotic apparatus protein 1
chr7_+_100770328 0.00 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chrX_-_153583257 0.00 ENST00000438732.1
FLNA
filamin A, alpha
chr5_-_135528822 0.00 ENST00000607574.1
AC009014.3
AC009014.3
chr14_-_22005018 0.00 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr3_+_122103014 0.00 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
FAM162A
family with sequence similarity 162, member A
chr11_-_61124776 0.00 ENST00000542361.1
CYB561A3
cytochrome b561 family, member A3

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.2 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.1 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) regulation of positive thymic T cell selection(GO:1902232)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0006097 glyoxylate cycle(GO:0006097)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0002353 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.0 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.1 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling