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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR1I2
Z-value: 0.94
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Transcription factors associated with NR1I2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_67563250 Show fit | 0.52 |
ENST00000566907.1
|
family with sequence similarity 65, member A |
|
| chr22_+_22676808 Show fit | 0.50 |
ENST00000390290.2
|
immunoglobulin lambda variable 1-51 |
|
| chr3_-_69590486 Show fit | 0.45 |
ENST00000497880.1
|
FERM domain containing 4B |
|
| chr12_+_34175398 Show fit | 0.44 |
ENST00000538927.1
|
ALG10, alpha-1,2-glucosyltransferase |
|
| chr2_+_181988620 Show fit | 0.43 |
ENST00000428474.1
ENST00000424655.1 |
AC104820.2 |
|
| chr6_+_12007963 Show fit | 0.40 |
ENST00000607445.1
|
RP11-456H18.2 |
|
| chr19_+_2977444 Show fit | 0.37 |
ENST00000246112.4
ENST00000453329.1 ENST00000482627.1 ENST00000452088.1 |
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) |
|
| chr13_-_95364389 Show fit | 0.34 |
ENST00000376945.2
|
SRY (sex determining region Y)-box 21 |
|
| chr4_+_183065793 Show fit | 0.34 |
ENST00000512480.1
|
teneurin transmembrane protein 3 |
|
| chr13_+_25670268 Show fit | 0.33 |
ENST00000281589.3
|
poly(A) binding protein, cytoplasmic 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 0.4 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.1 | 0.4 | GO:2000567 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
| 0.0 | 0.4 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.0 | 0.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 0.3 | GO:0072361 | regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) |
| 0.1 | 0.3 | GO:0008057 | eye pigment granule organization(GO:0008057) |
| 0.1 | 0.3 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.3 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.1 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.1 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.0 | 0.1 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.5 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.0 | 0.5 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.4 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.1 | 0.4 | GO:0023030 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
| 0.0 | 0.4 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 0.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.3 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 0.3 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.0 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.4 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |