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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1D1

Z-value: 0.38

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_38256990-0.187.3e-01Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_37880543 0.20 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_6900201 0.16 ENST00000480801.1
ALOX12
arachidonate 12-lipoxygenase
chr19_-_23433144 0.15 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
ZNF724P
zinc finger protein 724, pseudogene
chr1_-_147245445 0.13 ENST00000430508.1
GJA5
gap junction protein, alpha 5, 40kDa
chr1_+_20915409 0.11 ENST00000375071.3
CDA
cytidine deaminase
chr6_+_31543334 0.11 ENST00000449264.2
TNF
tumor necrosis factor
chr11_+_327171 0.10 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr1_-_147245484 0.10 ENST00000271348.2
GJA5
gap junction protein, alpha 5, 40kDa
chr8_+_101162812 0.10 ENST00000353107.3
ENST00000522439.1
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr4_-_82965397 0.09 ENST00000512716.1
ENST00000514050.1
ENST00000512343.1
ENST00000510780.1
ENST00000508294.1
RASGEF1B
RP11-689K5.3
RasGEF domain family, member 1B
RP11-689K5.3
chr12_-_110883346 0.08 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr17_-_72588422 0.08 ENST00000375352.1
CD300LD
CD300 molecule-like family member d
chr12_+_57854274 0.07 ENST00000528432.1
GLI1
GLI family zinc finger 1
chrX_+_54947229 0.07 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chr3_-_45957088 0.07 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr16_+_71392616 0.07 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr5_-_43313574 0.07 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_-_26232951 0.07 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr7_+_64126535 0.06 ENST00000344930.3
ZNF107
zinc finger protein 107
chr19_+_21688366 0.06 ENST00000358491.4
ENST00000597078.1
ZNF429
zinc finger protein 429
chr14_-_24733444 0.06 ENST00000560478.1
ENST00000560443.1
TGM1
transglutaminase 1
chr5_+_154173697 0.06 ENST00000518742.1
LARP1
La ribonucleoprotein domain family, member 1
chr1_-_26232522 0.06 ENST00000399728.1
STMN1
stathmin 1
chr1_-_32403903 0.06 ENST00000344035.6
ENST00000356536.3
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr1_-_38218577 0.06 ENST00000540011.1
EPHA10
EPH receptor A10
chr2_+_63816269 0.05 ENST00000432309.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr2_+_63816126 0.05 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_-_111991850 0.05 ENST00000411751.2
WDR77
WD repeat domain 77
chr14_-_50999190 0.05 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr15_-_65903512 0.05 ENST00000567923.1
VWA9
von Willebrand factor A domain containing 9
chr2_+_103353367 0.05 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
TMEM182
transmembrane protein 182
chr4_+_1873100 0.05 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr9_+_91150016 0.05 ENST00000375854.3
ENST00000375855.3
NXNL2
nucleoredoxin-like 2
chr11_+_125365110 0.04 ENST00000527818.1
AP000708.1
AP000708.1
chr6_+_63921351 0.04 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr11_-_125365435 0.04 ENST00000524435.1
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr19_-_22605136 0.04 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98
zinc finger protein 98
chr9_+_116343192 0.04 ENST00000471324.2
RGS3
regulator of G-protein signaling 3
chrX_+_24167746 0.04 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr14_+_74815116 0.04 ENST00000256362.4
VRTN
vertebrae development associated
chr14_-_23770683 0.04 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E
protein phosphatase 1, regulatory subunit 3E
chr14_+_50999744 0.04 ENST00000441560.2
ATL1
atlastin GTPase 1
chr12_-_123755639 0.04 ENST00000535979.1
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr19_+_21324863 0.04 ENST00000598331.1
ZNF431
zinc finger protein 431
chr14_-_50999307 0.04 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_197169672 0.04 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chrX_-_49089771 0.03 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr10_-_43762329 0.03 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr1_-_111991908 0.03 ENST00000235090.5
WDR77
WD repeat domain 77
chr19_+_22235279 0.03 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257
zinc finger protein 257
chr10_-_105156198 0.03 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
USMG5
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr11_-_327537 0.03 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr4_-_21699380 0.03 ENST00000382148.3
KCNIP4
Kv channel interacting protein 4
chr1_-_26233423 0.03 ENST00000357865.2
STMN1
stathmin 1
chr22_+_35776354 0.03 ENST00000412893.1
HMOX1
heme oxygenase (decycling) 1
chr1_+_218519577 0.03 ENST00000366930.4
ENST00000366929.4
TGFB2
transforming growth factor, beta 2
chr1_+_200863949 0.03 ENST00000413687.2
C1orf106
chromosome 1 open reading frame 106
chr1_-_11865351 0.03 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_-_154178803 0.03 ENST00000368525.3
C1orf189
chromosome 1 open reading frame 189
chr19_-_19932501 0.03 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506
CTC-559E9.4
zinc finger protein 506
CTC-559E9.4
chr11_-_125366018 0.03 ENST00000527534.1
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr19_+_38880695 0.03 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr12_-_7125770 0.03 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr7_-_100493482 0.03 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE
acetylcholinesterase (Yt blood group)
chr19_+_21264980 0.03 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714
zinc finger protein 714
chr22_-_47882857 0.02 ENST00000405369.3
LL22NC03-75H12.2
Novel protein; Uncharacterized protein
chr7_+_139025875 0.02 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chr1_+_161719552 0.02 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr19_-_51220176 0.02 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chrX_+_24167828 0.02 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chr19_+_22235310 0.02 ENST00000600162.1
ZNF257
zinc finger protein 257
chr19_+_21265028 0.02 ENST00000291770.7
ZNF714
zinc finger protein 714
chr1_-_1690014 0.02 ENST00000400922.2
ENST00000342348.5
NADK
NAD kinase
chr7_+_114562172 0.02 ENST00000393486.1
ENST00000257724.3
MDFIC
MyoD family inhibitor domain containing
chr1_+_197382957 0.02 ENST00000367397.1
CRB1
crumbs homolog 1 (Drosophila)
chr19_+_21264943 0.02 ENST00000597424.1
ZNF714
zinc finger protein 714
chr10_+_90346519 0.02 ENST00000371939.3
LIPJ
lipase, family member J
chr4_+_169842707 0.02 ENST00000503290.1
PALLD
palladin, cytoskeletal associated protein
chr2_+_63816295 0.02 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_-_226374373 0.02 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr19_-_18995029 0.02 ENST00000596048.1
CERS1
ceramide synthase 1
chr1_+_203764742 0.02 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr17_-_38074859 0.02 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB
gasdermin B
chr1_+_159796589 0.01 ENST00000368104.4
SLAMF8
SLAM family member 8
chr17_-_59940705 0.01 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr1_+_2398876 0.01 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr17_-_7145475 0.01 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP
GABA(A) receptor-associated protein
chr1_-_11866034 0.01 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_-_11007927 0.01 ENST00000468348.1
C1orf127
chromosome 1 open reading frame 127
chr9_+_103790991 0.01 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr3_+_171758344 0.01 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr13_+_113623509 0.01 ENST00000535094.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_+_99282570 0.01 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr16_+_4606347 0.01 ENST00000444310.4
C16orf96
chromosome 16 open reading frame 96
chr19_-_58071201 0.01 ENST00000325134.5
ENST00000457177.1
ZNF550
zinc finger protein 550
chr22_-_28316116 0.01 ENST00000415296.1
PITPNB
phosphatidylinositol transfer protein, beta
chrX_+_68725084 0.01 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr7_+_114562616 0.01 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr16_-_18468926 0.01 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr18_-_19284724 0.01 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr17_-_74528128 0.01 ENST00000590175.1
CYGB
cytoglobin
chr1_+_159796534 0.01 ENST00000289707.5
SLAMF8
SLAM family member 8
chr11_+_7534999 0.01 ENST00000528947.1
ENST00000299492.4
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_167525277 0.01 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr13_+_100741269 0.01 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr15_-_65903407 0.01 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
VWA9
von Willebrand factor A domain containing 9
chr19_+_21203426 0.01 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430
zinc finger protein 430
chr9_-_35112376 0.01 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chr15_-_65903574 0.01 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
VWA9
von Willebrand factor A domain containing 9
chr7_-_30009542 0.01 ENST00000438497.1
SCRN1
secernin 1
chr10_+_23216944 0.01 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
ARMC3
armadillo repeat containing 3
chr17_+_15637150 0.01 ENST00000578506.1
TBC1D26
TBC1 domain family, member 26
chr2_-_73053126 0.01 ENST00000272427.6
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chr9_+_139221880 0.01 ENST00000392945.3
ENST00000440944.1
GPSM1
G-protein signaling modulator 1
chr7_-_100493744 0.00 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chrY_+_2803322 0.00 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY
zinc finger protein, Y-linked
chr19_-_14629224 0.00 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr14_-_50999373 0.00 ENST00000554273.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr9_+_136243264 0.00 ENST00000371955.1
C9orf96
chromosome 9 open reading frame 96
chr9_-_136242956 0.00 ENST00000371989.3
ENST00000485435.2
SURF4
surfeit 4
chr19_-_12833164 0.00 ENST00000356861.5
TNPO2
transportin 2
chr13_+_113622810 0.00 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_31938700 0.00 ENST00000495340.1
DXO
decapping exoribonuclease
chr16_+_855443 0.00 ENST00000301698.1
PRR25
proline rich 25
chr2_+_63816087 0.00 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_+_168250194 0.00 ENST00000367821.3
TBX19
T-box 19
chr2_-_64371546 0.00 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0003193 pulmonary valve formation(GO:0003193) atrial ventricular junction remodeling(GO:0003294) foramen ovale closure(GO:0035922) atrial cardiac muscle cell to AV node cell communication by electrical coupling(GO:0086044) bundle of His cell to Purkinje myocyte communication by electrical coupling(GO:0086054) Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling(GO:0086055) regulation of Purkinje myocyte action potential(GO:0098906) vasomotion(GO:1990029)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.0 0.1 GO:2001302 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.0 0.1 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0060032 notochord regression(GO:0060032)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.0 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.0 GO:0003284 septum primum development(GO:0003284)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0086079 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling(GO:0086076) gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling(GO:0086078) gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling(GO:0086079)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.1 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)