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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR0B1
Z-value: 0.91
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Transcription factors associated with NR0B1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR0B1 | hg19_v2_chrX_-_30326445_30326605 | 0.91 | 1.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_125486939 Show fit | 0.71 |
ENST00000303545.3
|
ring finger protein 139 |
|
| chr16_+_53164956 Show fit | 0.59 |
ENST00000563410.1
|
chromodomain helicase DNA binding protein 9 |
|
| chr1_+_6052700 Show fit | 0.55 |
ENST00000378092.1
ENST00000445501.1 |
potassium voltage-gated channel, shaker-related subfamily, beta member 2 |
|
| chr11_-_73471655 Show fit | 0.55 |
ENST00000400470.2
|
RAB6A, member RAS oncogene family |
|
| chr3_-_169381166 Show fit | 0.53 |
ENST00000486748.1
|
MDS1 and EVI1 complex locus |
|
| chr13_-_76111945 Show fit | 0.53 |
ENST00000355801.4
ENST00000406936.3 |
COMM domain containing 6 |
|
| chr1_-_171711177 Show fit | 0.49 |
ENST00000415773.1
ENST00000367740.2 |
vesicle-associated membrane protein 4 |
|
| chr7_+_149411860 Show fit | 0.48 |
ENST00000486744.1
|
KRAB-A domain containing 1 |
|
| chr19_-_10628098 Show fit | 0.48 |
ENST00000590601.1
|
sphingosine-1-phosphate receptor 5 |
|
| chr12_+_56661461 Show fit | 0.47 |
ENST00000546544.1
ENST00000553234.1 |
coenzyme Q10 homolog A (S. cerevisiae) |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR0B1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.8 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.2 | 0.6 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.2 | 0.6 | GO:1904799 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 0.1 | 0.6 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.6 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 0.6 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 0.6 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.0 | 0.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.6 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.7 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.6 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.5 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 0.5 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.4 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 0.7 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.0 | 0.7 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.6 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 0.6 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 0.6 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 0.6 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 0.6 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.5 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |