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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NKX6-2
Z-value: 0.95
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Transcription factors associated with NKX6-2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_23891693 Show fit | 1.05 |
ENST00000264867.2
|
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
|
| chr8_+_92114873 Show fit | 0.88 |
ENST00000343709.3
ENST00000448384.2 |
leucine rich repeat containing 69 |
|
| chr6_-_113953705 Show fit | 0.69 |
ENST00000452675.1
|
RP11-367G18.1 |
|
| chr7_-_77325545 Show fit | 0.61 |
ENST00000447009.1
ENST00000416650.1 ENST00000440088.1 ENST00000430801.1 ENST00000398043.2 |
RSBN1L antisense RNA 1 |
|
| chr6_+_41021027 Show fit | 0.58 |
ENST00000244669.2
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 |
|
| chr7_-_84122033 Show fit | 0.58 |
ENST00000424555.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chrX_-_80457385 Show fit | 0.52 |
ENST00000451455.1
ENST00000436386.1 ENST00000358130.2 |
high mobility group nucleosome binding domain 5 |
|
| chr15_+_49715449 Show fit | 0.49 |
ENST00000560979.1
|
fibroblast growth factor 7 |
|
| chr9_+_109685630 Show fit | 0.47 |
ENST00000451160.2
|
Uncharacterized protein |
|
| chr18_+_76829441 Show fit | 0.44 |
ENST00000458297.2
|
ATPase, class II, type 9B |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640) |
| 0.2 | 0.8 | GO:0060437 | lung growth(GO:0060437) |
| 0.0 | 0.8 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.1 | 0.6 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.1 | 0.6 | GO:0009972 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.0 | 0.5 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.1 | 0.4 | GO:0070408 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
| 0.1 | 0.4 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.1 | 0.4 | GO:0060264 | respiratory burst involved in inflammatory response(GO:0002536) regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.0 | 0.4 | GO:0098535 | de novo centriole assembly(GO:0098535) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.4 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 0.4 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.2 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.0 | 0.2 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.8 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.6 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.6 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 0.4 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.1 | 0.4 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.0 | 0.4 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.8 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 0.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |