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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NKX2-8
Z-value: 0.68
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Transcription factors associated with NKX2-8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-8 | hg19_v2_chr14_-_37051798_37051831 | -0.15 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_27998689 Show fit | 0.82 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr2_-_25451065 Show fit | 0.53 |
ENST00000606328.1
|
RP11-458N5.1 |
|
| chr17_+_67590125 Show fit | 0.53 |
ENST00000591334.1
|
AC003051.1 |
|
| chrX_+_115567767 Show fit | 0.42 |
ENST00000371900.4
|
solute carrier family 6 (amino acid transporter), member 14 |
|
| chr5_-_176056974 Show fit | 0.39 |
ENST00000510387.1
ENST00000506696.1 |
synuclein, beta |
|
| chr1_+_10057274 Show fit | 0.38 |
ENST00000294435.7
|
retinol binding protein 7, cellular |
|
| chr3_+_177545563 Show fit | 0.32 |
ENST00000434309.1
|
RP11-91K9.1 |
|
| chr22_+_38609538 Show fit | 0.31 |
ENST00000407965.1
|
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
|
| chr6_+_43968306 Show fit | 0.31 |
ENST00000442114.2
ENST00000336600.5 ENST00000439969.2 |
chromosome 6 open reading frame 223 |
|
| chr14_-_24732403 Show fit | 0.28 |
ENST00000206765.6
|
transglutaminase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:1904180 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 0.1 | 0.5 | GO:0043163 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.0 | 0.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 0.3 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.0 | 0.3 | GO:0007567 | parturition(GO:0007567) |
| 0.1 | 0.2 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.0 | 0.2 | GO:0030578 | PML body organization(GO:0030578) |
| 0.0 | 0.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.0 | 0.2 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.0 | 0.1 | GO:0031049 | mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.1 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.1 | GO:0070110 | ciliary neurotrophic factor receptor complex(GO:0070110) |
| 0.0 | 0.1 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 0.1 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.0 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.0 | 0.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.4 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 0.3 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.3 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 0.2 | GO:0031783 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
| 0.0 | 0.2 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.2 | GO:1903763 | gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
| 0.0 | 0.1 | GO:0035501 | MH1 domain binding(GO:0035501) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |