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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NKX2-6
Z-value: 0.87
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Transcription factors associated with NKX2-6
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_41120896 Show fit | 0.45 |
ENST00000299174.5
ENST00000427255.2 |
protein phosphatase 1, regulatory (inhibitor) subunit 14D |
|
| chr17_-_55911970 Show fit | 0.45 |
ENST00000581805.1
ENST00000580960.1 |
RP11-60A24.3 |
|
| chr7_+_141463897 Show fit | 0.42 |
ENST00000247879.2
|
taste receptor, type 2, member 3 |
|
| chr3_+_156807663 Show fit | 0.37 |
ENST00000467995.1
ENST00000474477.1 ENST00000471719.1 |
long intergenic non-protein coding RNA 881 |
|
| chr12_-_39300071 Show fit | 0.34 |
ENST00000550863.1
|
copine VIII |
|
| chr11_-_111383064 Show fit | 0.34 |
ENST00000525791.1
ENST00000456861.2 ENST00000356018.2 |
B-cell translocation gene 4 |
|
| chr3_-_42003613 Show fit | 0.33 |
ENST00000414606.1
|
unc-51 like kinase 4 |
|
| chr6_+_24775641 Show fit | 0.32 |
ENST00000378054.2
ENST00000476555.1 |
geminin, DNA replication inhibitor |
|
| chr2_-_36779411 Show fit | 0.32 |
ENST00000406220.1
|
Uncharacterized protein |
|
| chr13_-_26452679 Show fit | 0.32 |
ENST00000596729.1
|
Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.4 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.0 | 0.3 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.0 | 0.3 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 0.3 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.0 | 0.3 | GO:0001554 | luteolysis(GO:0001554) |
| 0.0 | 0.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.2 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.0 | 0.2 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.0 | 0.2 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.2 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.0 | 0.1 | GO:0005715 | late recombination nodule(GO:0005715) |
| 0.0 | 0.1 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 0.1 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.1 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 0.1 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.5 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 0.4 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 0.4 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 0.3 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.0 | 0.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 0.2 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.1 | 0.2 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.0 | 0.2 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.3 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |