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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-6

Z-value: 0.87

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_41120896 0.45 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr17_-_55911970 0.45 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr7_+_141463897 0.42 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr3_+_156807663 0.37 ENST00000467995.1
ENST00000474477.1
ENST00000471719.1
LINC00881
long intergenic non-protein coding RNA 881
chr12_-_39300071 0.34 ENST00000550863.1
CPNE8
copine VIII
chr11_-_111383064 0.34 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
BTG4
B-cell translocation gene 4
chr3_-_42003613 0.33 ENST00000414606.1
ULK4
unc-51 like kinase 4
chr6_+_24775641 0.32 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr2_-_36779411 0.32 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr13_-_26452679 0.32 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr13_-_30951282 0.30 ENST00000420219.1
LINC00426
long intergenic non-protein coding RNA 426
chr1_-_149400542 0.29 ENST00000392948.2
HIST2H3PS2
histone cluster 2, H3, pseudogene 2
chr1_-_17231271 0.28 ENST00000606899.1
RP11-108M9.6
RP11-108M9.6
chr13_-_48669232 0.26 ENST00000258648.2
ENST00000378586.1
MED4
mediator complex subunit 4
chr13_-_48669204 0.25 ENST00000417167.1
MED4
mediator complex subunit 4
chr8_-_95220775 0.23 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr6_+_122793058 0.23 ENST00000392491.2
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr12_-_56236690 0.23 ENST00000322569.4
MMP19
matrix metallopeptidase 19
chr6_+_12007897 0.22 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr8_+_99076509 0.22 ENST00000318528.3
C8orf47
chromosome 8 open reading frame 47
chr19_+_50433476 0.22 ENST00000596658.1
ATF5
activating transcription factor 5
chr9_+_131452239 0.22 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr19_-_43835582 0.22 ENST00000595748.1
CTC-490G23.2
CTC-490G23.2
chr10_-_4720301 0.22 ENST00000449712.1
LINC00704
long intergenic non-protein coding RNA 704
chr2_+_102928009 0.21 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr2_-_112237835 0.21 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr14_+_65182395 0.21 ENST00000554088.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr8_+_42396936 0.20 ENST00000416469.2
SMIM19
small integral membrane protein 19
chr7_-_91509972 0.19 ENST00000425936.1
MTERF
mitochondrial transcription termination factor
chr2_+_87769459 0.19 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr1_-_108231101 0.19 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr5_+_173763250 0.19 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1
RP11-267A15.1
chr6_-_131299929 0.18 ENST00000531356.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr10_-_27529486 0.18 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr5_-_43412418 0.18 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr17_+_33914460 0.17 ENST00000537622.2
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr11_-_62521614 0.17 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr4_+_186317133 0.17 ENST00000507753.1
ANKRD37
ankyrin repeat domain 37
chr12_-_76377795 0.17 ENST00000552856.1
RP11-114H23.1
RP11-114H23.1
chr7_+_23719749 0.17 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr2_-_25565377 0.16 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr5_+_74907284 0.16 ENST00000601380.2
ANKDD1B
ankyrin repeat and death domain containing 1B
chr3_+_113609472 0.16 ENST00000472026.1
ENST00000462838.1
GRAMD1C
GRAM domain containing 1C
chr11_-_64527425 0.16 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chr3_+_32726774 0.16 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr1_+_19578033 0.15 ENST00000330263.4
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr7_+_121513143 0.15 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr14_+_68189190 0.15 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr17_-_34890709 0.15 ENST00000544606.1
MYO19
myosin XIX
chr1_-_200638964 0.15 ENST00000367348.3
ENST00000447706.2
ENST00000331314.6
DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr10_+_121652204 0.14 ENST00000369075.3
ENST00000543134.1
SEC23IP
SEC23 interacting protein
chr1_-_78444776 0.14 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr6_+_10528560 0.14 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chrX_+_52841228 0.14 ENST00000351072.1
ENST00000425386.1
ENST00000375503.3
XAGE5
X antigen family, member 5
chr9_+_127023704 0.14 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr8_-_133637624 0.14 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr1_-_149785236 0.14 ENST00000331491.1
HIST2H3D
histone cluster 2, H3d
chr6_+_155443048 0.14 ENST00000535583.1
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_+_122709200 0.13 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr3_+_42544084 0.13 ENST00000543411.1
ENST00000438259.2
ENST00000439731.1
ENST00000325123.4
VIPR1
vasoactive intestinal peptide receptor 1
chr1_+_159796534 0.13 ENST00000289707.5
SLAMF8
SLAM family member 8
chr3_+_99986036 0.13 ENST00000471098.1
TBC1D23
TBC1 domain family, member 23
chr17_+_33914276 0.13 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr7_+_5938386 0.13 ENST00000537980.1
CCZ1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr13_-_30951074 0.13 ENST00000416261.1
LINC00426
long intergenic non-protein coding RNA 426
chr11_-_8816375 0.13 ENST00000530580.1
ST5
suppression of tumorigenicity 5
chr12_+_118454500 0.13 ENST00000537315.1
ENST00000229043.3
ENST00000484086.2
ENST00000420967.1
ENST00000454402.2
ENST00000392542.2
ENST00000535092.1
RFC5
replication factor C (activator 1) 5, 36.5kDa
chr7_-_6865826 0.13 ENST00000538180.1
CCZ1B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr17_-_34890037 0.13 ENST00000589404.1
MYO19
myosin XIX
chr5_+_147443534 0.13 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5
serine peptidase inhibitor, Kazal type 5
chr16_+_69373323 0.13 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr5_+_78407602 0.13 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr4_+_91048706 0.12 ENST00000509176.1
CCSER1
coiled-coil serine-rich protein 1
chr2_-_175462934 0.12 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr19_+_10563567 0.12 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr16_+_89628778 0.12 ENST00000472354.1
RPL13
ribosomal protein L13
chr1_+_20512568 0.12 ENST00000375099.3
UBXN10
UBX domain protein 10
chr19_+_496454 0.12 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
chr13_+_115000556 0.12 ENST00000252458.6
CDC16
cell division cycle 16
chr17_-_34890665 0.12 ENST00000586007.1
MYO19
myosin XIX
chr1_-_78444738 0.12 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr14_+_50779029 0.12 ENST00000245448.6
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr12_-_15103621 0.11 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr9_-_33402506 0.11 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr2_+_219246746 0.11 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr19_+_50148087 0.11 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr9_+_131447342 0.11 ENST00000409104.3
SET
SET nuclear oncogene
chr16_+_58783542 0.11 ENST00000500117.1
ENST00000565722.1
RP11-410D17.2
RP11-410D17.2
chr7_+_5938351 0.11 ENST00000325974.6
CCZ1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr3_+_32726620 0.11 ENST00000331889.6
ENST00000328834.5
CNOT10
CCR4-NOT transcription complex, subunit 10
chr4_-_77996032 0.11 ENST00000505609.1
CCNI
cyclin I
chr14_+_31494672 0.11 ENST00000542754.2
ENST00000313566.6
AP4S1
adaptor-related protein complex 4, sigma 1 subunit
chr3_-_42003479 0.10 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr5_-_175612149 0.10 ENST00000515403.1
RP11-844P9.2
RP11-844P9.2
chr22_-_37882395 0.10 ENST00000416983.3
ENST00000424765.2
ENST00000356998.3
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_-_42825983 0.10 ENST00000506577.1
SEPP1
selenoprotein P, plasma, 1
chr6_-_110012380 0.10 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
AK9
adenylate kinase 9
chr8_-_17942432 0.10 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr13_+_27998681 0.10 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr14_+_52164675 0.10 ENST00000555936.1
FRMD6
FERM domain containing 6
chr8_+_41386761 0.10 ENST00000523277.2
GINS4
GINS complex subunit 4 (Sld5 homolog)
chr20_+_13202418 0.10 ENST00000262487.4
ISM1
isthmin 1, angiogenesis inhibitor
chr11_-_105892937 0.10 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr17_-_26903900 0.10 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr2_-_207082624 0.09 ENST00000458440.1
ENST00000437420.1
GPR1
G protein-coupled receptor 1
chr3_-_121379739 0.09 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_37035289 0.09 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr17_-_74049720 0.09 ENST00000602720.1
SRP68
signal recognition particle 68kDa
chr7_-_91509986 0.09 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
MTERF
mitochondrial transcription termination factor
chr17_-_5522731 0.09 ENST00000576905.1
NLRP1
NLR family, pyrin domain containing 1
chr13_+_115000521 0.09 ENST00000252457.5
ENST00000375308.1
CDC16
cell division cycle 16
chr20_-_1373606 0.09 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FKBP1A
FK506 binding protein 1A, 12kDa
chr2_-_175462456 0.09 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr17_+_49337881 0.09 ENST00000225298.7
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_-_157069590 0.09 ENST00000454449.2
ETV3L
ets variant 3-like
chr15_-_55563072 0.09 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr2_-_203776864 0.08 ENST00000261015.4
WDR12
WD repeat domain 12
chr11_-_65624415 0.08 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr12_-_57328187 0.08 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr8_-_121457608 0.08 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr1_-_21113105 0.08 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3
chr1_-_31902614 0.08 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr17_+_41150479 0.08 ENST00000589913.1
RPL27
ribosomal protein L27
chr1_+_159796589 0.08 ENST00000368104.4
SLAMF8
SLAM family member 8
chrY_+_15418467 0.08 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr17_+_80517216 0.08 ENST00000531030.1
ENST00000526383.2
FOXK2
forkhead box K2
chr9_+_74729511 0.08 ENST00000545168.1
GDA
guanine deaminase
chr17_+_57807062 0.08 ENST00000587259.1
VMP1
vacuole membrane protein 1
chr17_+_41150793 0.08 ENST00000586277.1
RPL27
ribosomal protein L27
chr1_+_144989309 0.08 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr11_-_65629497 0.08 ENST00000532134.1
CFL1
cofilin 1 (non-muscle)
chr5_+_140071178 0.07 ENST00000508522.1
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr1_+_233086326 0.07 ENST00000366628.5
ENST00000366627.4
NTPCR
nucleoside-triphosphatase, cancer-related
chr20_+_54967663 0.07 ENST00000452950.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_+_54569968 0.07 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr9_-_70465758 0.07 ENST00000489273.1
CBWD5
COBW domain containing 5
chr3_-_56950407 0.07 ENST00000496106.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr8_+_22414182 0.07 ENST00000524057.1
SORBS3
sorbin and SH3 domain containing 3
chr22_+_42017987 0.07 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr12_-_86230315 0.07 ENST00000361228.3
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr17_-_34329084 0.07 ENST00000354059.4
ENST00000536149.1
CCL15
CCL14
chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr8_+_20054878 0.07 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr5_+_140071011 0.07 ENST00000230771.3
ENST00000509299.1
ENST00000503873.1
ENST00000435019.2
ENST00000437649.2
ENST00000432671.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr9_-_19065082 0.07 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr3_-_46249878 0.07 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr4_-_170924888 0.07 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr5_-_111091948 0.07 ENST00000447165.2
NREP
neuronal regeneration related protein
chr12_-_57039739 0.07 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr8_+_42396712 0.07 ENST00000518574.1
ENST00000417410.2
ENST00000414154.2
SMIM19
small integral membrane protein 19
chr6_-_34664612 0.06 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr9_-_134406611 0.06 ENST00000372208.3
ENST00000372215.4
UCK1
uridine-cytidine kinase 1
chr2_+_86426478 0.06 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
MRPL35
mitochondrial ribosomal protein L35
chr4_+_17579110 0.06 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr11_-_61687739 0.06 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr11_+_6128914 0.06 ENST00000316529.3
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr20_-_1373726 0.06 ENST00000400137.4
FKBP1A
FK506 binding protein 1A, 12kDa
chr12_-_8088773 0.06 ENST00000544291.1
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr8_-_62602327 0.06 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr12_-_71182695 0.06 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr19_-_37663332 0.06 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr9_-_134406565 0.06 ENST00000372210.3
ENST00000372211.3
UCK1
uridine-cytidine kinase 1
chr13_+_44453969 0.06 ENST00000325686.6
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr12_-_371994 0.06 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr12_-_56236711 0.06 ENST00000409200.3
MMP19
matrix metallopeptidase 19
chr14_-_31856397 0.06 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr12_+_70219052 0.06 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr19_+_52074502 0.06 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr3_+_37034823 0.06 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr9_+_4839762 0.05 ENST00000448872.2
ENST00000441844.1
RCL1
RNA terminal phosphate cyclase-like 1
chr20_+_32254286 0.05 ENST00000330271.4
ACTL10
actin-like 10
chr17_+_41150290 0.05 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr17_-_49337392 0.05 ENST00000376381.2
ENST00000586178.1
MBTD1
mbt domain containing 1
chr12_+_44152740 0.05 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
IRAK4
interleukin-1 receptor-associated kinase 4
chr4_-_48082192 0.05 ENST00000507351.1
TXK
TXK tyrosine kinase
chr22_+_44427230 0.05 ENST00000444029.1
PARVB
parvin, beta
chr1_+_202431859 0.05 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr11_+_27062860 0.05 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_+_58755184 0.05 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr1_+_110163202 0.05 ENST00000531203.1
ENST00000256578.3
AMPD2
adenosine monophosphate deaminase 2
chr4_+_113739244 0.05 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr10_-_91403625 0.05 ENST00000322191.6
ENST00000342512.3
ENST00000371774.2
PANK1
pantothenate kinase 1
chr4_-_175041663 0.05 ENST00000503140.1
RP11-148L24.1
RP11-148L24.1
chr2_-_69870747 0.05 ENST00000409068.1
AAK1
AP2 associated kinase 1
chr18_+_39535239 0.05 ENST00000585528.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr17_-_72527605 0.05 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr1_-_31538517 0.05 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr17_-_6524159 0.05 ENST00000589033.1
KIAA0753
KIAA0753
chr7_+_16700806 0.04 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr10_+_135204338 0.04 ENST00000468317.2
RP11-108K14.8
Mitochondrial GTPase 1
chr17_-_44896047 0.04 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr15_+_84841242 0.04 ENST00000558195.1
RP11-182J1.16
ubiquitin-conjugating enzyme E2Q family member 2-like
chr19_-_49552006 0.04 ENST00000391869.3
CGB1
chorionic gonadotropin, beta polypeptide 1
chr22_+_23229960 0.04 ENST00000526893.1
ENST00000532223.2
ENST00000531372.1
IGLL5
immunoglobulin lambda-like polypeptide 5
chr7_-_112430647 0.04 ENST00000312814.6
TMEM168
transmembrane protein 168
chr12_+_54674482 0.04 ENST00000547708.1
ENST00000340913.6
ENST00000551702.1
ENST00000330752.8
ENST00000547276.1
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr21_-_31852663 0.04 ENST00000390689.2
KRTAP19-1
keratin associated protein 19-1
chr12_-_89919965 0.04 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr19_-_2282167 0.04 ENST00000342063.3
C19orf35
chromosome 19 open reading frame 35
chr2_+_70142232 0.04 ENST00000540449.1
MXD1
MAX dimerization protein 1
chr18_+_7754957 0.04 ENST00000400053.4
PTPRM
protein tyrosine phosphatase, receptor type, M

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 0.1 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.3 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0061568 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.0 0.1 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.0 0.1 GO:0070839 divalent metal ion export(GO:0070839)
0.0 0.3 GO:0001554 luteolysis(GO:0001554)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0006147 guanine catabolic process(GO:0006147)
0.0 0.2 GO:0071964 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0002784 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0070838 divalent metal ion transport(GO:0070838)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.2 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.1 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.0 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.1 GO:0032680 regulation of tumor necrosis factor production(GO:0032680)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.2 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.3 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.0 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.2 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.2 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 0.1 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.0 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling