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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-3

Z-value: 0.94

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_114163945 0.73 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chrX_+_9502971 0.63 ENST00000452824.1
TBL1X
transducin (beta)-like 1X-linked
chr13_-_45048386 0.61 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr12_+_111051902 0.43 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chrX_-_108868390 0.42 ENST00000372101.2
KCNE1L
KCNE1-like
chr3_+_186743261 0.42 ENST00000423451.1
ENST00000446170.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr12_-_123565834 0.39 ENST00000546049.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr6_-_10435032 0.37 ENST00000491317.1
ENST00000496285.1
ENST00000479822.1
ENST00000487130.1
LINC00518
long intergenic non-protein coding RNA 518
chr12_+_111051832 0.35 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr2_-_98972468 0.35 ENST00000454230.1
AC092675.3
Uncharacterized protein
chr14_+_64565442 0.35 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr22_+_45714361 0.33 ENST00000452238.1
FAM118A
family with sequence similarity 118, member A
chr6_+_8652370 0.33 ENST00000503668.1
HULC
hepatocellular carcinoma up-regulated long non-coding RNA
chr2_-_37501692 0.33 ENST00000443977.1
PRKD3
protein kinase D3
chr2_+_64073187 0.30 ENST00000491621.1
UGP2
UDP-glucose pyrophosphorylase 2
chr1_-_46642154 0.29 ENST00000540385.1
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr16_-_79804394 0.29 ENST00000567993.1
RP11-345M22.2
RP11-345M22.2
chr12_+_25205155 0.29 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr1_-_205391178 0.28 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr16_-_18911366 0.28 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr11_-_46638720 0.27 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chr1_-_26147149 0.27 ENST00000536896.1
AL020996.1
Uncharacterized protein
chr7_+_56032652 0.27 ENST00000437587.1
GBAS
glioblastoma amplified sequence
chr14_+_36295504 0.26 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr2_+_204103663 0.26 ENST00000356079.4
ENST00000429815.2
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr5_+_150404904 0.26 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr18_-_25616519 0.25 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_+_71357744 0.25 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr10_+_13203543 0.25 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr5_-_114631958 0.24 ENST00000395557.4
CCDC112
coiled-coil domain containing 112
chr2_-_178128528 0.24 ENST00000397063.4
ENST00000421929.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr12_+_122018697 0.24 ENST00000541574.1
RP13-941N14.1
RP13-941N14.1
chr18_-_64271316 0.24 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr4_+_76439649 0.23 ENST00000507557.1
THAP6
THAP domain containing 6
chr3_-_122134882 0.22 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr12_-_124419531 0.21 ENST00000514254.2
DNAH10OS
dynein, axonemal, heavy chain 10 opposite strand
chr5_-_159846066 0.21 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr5_-_54988448 0.20 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr1_+_152943122 0.20 ENST00000328051.2
SPRR4
small proline-rich protein 4
chr1_+_205682497 0.20 ENST00000598338.1
AC119673.1
AC119673.1
chr2_+_204103733 0.20 ENST00000443941.1
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr5_-_42887494 0.19 ENST00000514218.1
SEPP1
selenoprotein P, plasma, 1
chr2_-_188419078 0.19 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_36295638 0.19 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr20_-_33539655 0.19 ENST00000451957.2
GSS
glutathione synthetase
chr8_-_99954788 0.19 ENST00000523601.1
STK3
serine/threonine kinase 3
chr6_-_46138676 0.19 ENST00000371383.2
ENST00000230565.3
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chrX_-_16730984 0.19 ENST00000380241.3
CTPS2
CTP synthase 2
chr3_+_113775594 0.18 ENST00000479882.1
ENST00000493014.1
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr4_-_104020968 0.18 ENST00000504285.1
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr18_-_51750948 0.18 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr19_+_15751689 0.18 ENST00000586182.2
ENST00000591058.1
ENST00000221307.8
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr7_-_29186008 0.18 ENST00000396276.3
ENST00000265394.5
CPVL
carboxypeptidase, vitellogenic-like
chr7_-_38948774 0.18 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr10_-_70092671 0.18 ENST00000358769.2
ENST00000432941.1
ENST00000495025.2
PBLD
phenazine biosynthesis-like protein domain containing
chr7_+_141463897 0.17 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr19_+_18485509 0.17 ENST00000597765.1
GDF15
growth differentiation factor 15
chr11_+_65266507 0.17 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr12_-_2966193 0.16 ENST00000382678.3
AC005841.1
Uncharacterized protein ENSP00000372125
chr6_+_134758827 0.16 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr8_-_17555164 0.16 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr4_-_75695366 0.16 ENST00000512743.1
BTC
betacellulin
chr15_+_58702742 0.16 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr5_+_150051149 0.16 ENST00000523553.1
MYOZ3
myozenin 3
chr14_+_67831576 0.16 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr4_+_48343339 0.16 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr11_-_65363259 0.16 ENST00000342202.4
KCNK7
potassium channel, subfamily K, member 7
chr10_-_76868931 0.16 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr3_-_69062764 0.16 ENST00000295571.5
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr4_-_36246060 0.16 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_50018140 0.16 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr2_+_242312264 0.16 ENST00000445489.1
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr12_-_42719885 0.15 ENST00000552673.1
ENST00000266529.3
ENST00000552235.1
ZCRB1
zinc finger CCHC-type and RNA binding motif 1
chr10_-_73976884 0.15 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr12_-_120315074 0.15 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr3_-_101039402 0.15 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr14_-_69263043 0.15 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr12_+_41136144 0.15 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr10_+_35464513 0.15 ENST00000494479.1
ENST00000463314.1
ENST00000342105.3
ENST00000495301.1
ENST00000463960.1
CREM
cAMP responsive element modulator
chrX_-_134049262 0.15 ENST00000370783.3
MOSPD1
motile sperm domain containing 1
chr2_-_188419200 0.15 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_-_76829125 0.15 ENST00000248598.5
FGL2
fibrinogen-like 2
chr3_-_123512688 0.14 ENST00000475616.1
MYLK
myosin light chain kinase
chrX_+_37865804 0.14 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr2_+_64069240 0.14 ENST00000497883.1
UGP2
UDP-glucose pyrophosphorylase 2
chr4_-_100242549 0.14 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr6_-_32731243 0.14 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr5_-_180688105 0.14 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr12_-_42878101 0.14 ENST00000552108.1
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_-_104531945 0.14 ENST00000551446.1
NFYB
nuclear transcription factor Y, beta
chr3_-_131753830 0.14 ENST00000429747.1
CPNE4
copine IV
chr9_-_75488984 0.14 ENST00000423171.1
ENST00000449235.1
ENST00000453787.1
RP11-151D14.1
RP11-151D14.1
chr4_-_52883786 0.14 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr22_+_45714672 0.13 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr4_-_90758227 0.13 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_-_108976410 0.13 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr1_+_174669653 0.13 ENST00000325589.5
RABGAP1L
RAB GTPase activating protein 1-like
chr5_-_132200477 0.13 ENST00000296875.2
GDF9
growth differentiation factor 9
chr1_+_174670143 0.13 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_71752838 0.13 ENST00000537930.1
NUMA1
nuclear mitotic apparatus protein 1
chr18_+_43684298 0.13 ENST00000282058.6
HAUS1
HAUS augmin-like complex, subunit 1
chr12_+_42719947 0.13 ENST00000395580.3
ENST00000337898.6
ENST00000358314.7
ENST00000395568.2
ENST00000256678.8
ENST00000449194.2
ENST00000552761.1
ENST00000317560.9
ENST00000432191.2
PPHLN1
periphilin 1
chr4_-_90758118 0.13 ENST00000420646.2
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_43824669 0.13 ENST00000372462.1
CDC20
cell division cycle 20
chr14_+_55494323 0.13 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr12_-_102591604 0.13 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr3_+_25831567 0.13 ENST00000280701.3
ENST00000420173.2
OXSM
3-oxoacyl-ACP synthase, mitochondrial
chr5_-_110848189 0.13 ENST00000296632.3
ENST00000512160.1
ENST00000509887.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr15_+_69452959 0.12 ENST00000261858.2
GLCE
glucuronic acid epimerase
chr14_-_50154921 0.12 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr5_+_112312399 0.12 ENST00000515408.1
ENST00000513585.1
DCP2
decapping mRNA 2
chr3_+_145782358 0.12 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr2_-_36825281 0.12 ENST00000405912.3
ENST00000379245.4
FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
chr9_-_138391692 0.12 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr4_+_189321881 0.12 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chrX_+_69509870 0.12 ENST00000374388.3
KIF4A
kinesin family member 4A
chr14_+_100531738 0.12 ENST00000555706.1
EVL
Enah/Vasp-like
chr9_+_131447342 0.12 ENST00000409104.3
SET
SET nuclear oncogene
chr14_-_90798273 0.12 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr16_+_56969284 0.12 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_+_202125219 0.12 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr19_-_1401486 0.12 ENST00000252288.2
ENST00000447102.3
GAMT
guanidinoacetate N-methyltransferase
chr3_+_182971018 0.12 ENST00000326505.3
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr7_+_6071007 0.12 ENST00000409061.1
ANKRD61
ankyrin repeat domain 61
chr4_+_139230865 0.12 ENST00000502757.1
ENST00000507145.1
ENST00000515282.1
ENST00000510736.1
LINC00499
long intergenic non-protein coding RNA 499
chr17_+_61905058 0.11 ENST00000375812.4
ENST00000581882.1
PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr1_+_152730499 0.11 ENST00000368773.1
KPRP
keratinocyte proline-rich protein
chrX_-_106362013 0.11 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RBM41
RNA binding motif protein 41
chr3_+_23847432 0.11 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr22_-_21213676 0.11 ENST00000449120.1
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr17_+_61904766 0.11 ENST00000581842.1
ENST00000582130.1
ENST00000584320.1
ENST00000585123.1
ENST00000580864.1
PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr7_-_86849836 0.11 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr12_+_116985896 0.11 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr4_-_39034542 0.11 ENST00000344606.6
TMEM156
transmembrane protein 156
chr2_+_64069459 0.11 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr22_-_30814469 0.11 ENST00000598426.1
KIAA1658
KIAA1658
chr3_-_180397256 0.11 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr4_-_120550146 0.11 ENST00000354960.3
PDE5A
phosphodiesterase 5A, cGMP-specific
chr7_-_130353553 0.11 ENST00000330992.7
ENST00000445977.2
COPG2
coatomer protein complex, subunit gamma 2
chr5_-_142814241 0.10 ENST00000504572.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_+_138210919 0.10 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr4_-_39033963 0.10 ENST00000381938.3
TMEM156
transmembrane protein 156
chr3_+_113775576 0.10 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr13_-_50018241 0.10 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr2_+_64068844 0.10 ENST00000337130.5
UGP2
UDP-glucose pyrophosphorylase 2
chr3_+_57094469 0.10 ENST00000334325.1
SPATA12
spermatogenesis associated 12
chr11_-_75017734 0.10 ENST00000532525.1
ARRB1
arrestin, beta 1
chr10_-_27529486 0.10 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chrX_-_21776281 0.10 ENST00000379494.3
SMPX
small muscle protein, X-linked
chr12_+_19389814 0.10 ENST00000536974.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr1_-_212965104 0.10 ENST00000422588.2
ENST00000366975.6
ENST00000366977.3
ENST00000366976.1
NSL1
NSL1, MIS12 kinetochore complex component
chr11_+_17599811 0.10 ENST00000342528.2
OTOG
otogelin
chr16_-_66952779 0.10 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr5_-_110848253 0.10 ENST00000505803.1
ENST00000502322.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr16_+_23765948 0.10 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr5_-_96518907 0.09 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2
chr12_+_57390745 0.09 ENST00000600202.1
HBCBP
HBcAg-binding protein; Uncharacterized protein
chr12_+_6309963 0.09 ENST00000382515.2
CD9
CD9 molecule
chr15_-_90437195 0.09 ENST00000560940.1
ENST00000558011.1
AP3S2
adaptor-related protein complex 3, sigma 2 subunit
chrX_-_49121165 0.09 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr4_+_76439665 0.09 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr3_-_122233723 0.09 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr18_+_32173276 0.09 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr7_+_1609765 0.09 ENST00000437964.1
ENST00000533935.1
ENST00000532358.1
ENST00000524978.1
PSMG3-AS1
PSMG3 antisense RNA 1 (head to head)
chr7_-_80548667 0.09 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_-_42623805 0.09 ENST00000456515.1
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
chr8_-_101718991 0.09 ENST00000517990.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr7_-_2883650 0.09 ENST00000544127.1
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr15_-_101142362 0.09 ENST00000559577.1
ENST00000561308.1
ENST00000560133.1
ENST00000560941.1
ENST00000559736.1
ENST00000560272.1
LINS
lines homolog (Drosophila)
chr2_-_172291273 0.09 ENST00000442778.1
ENST00000453846.1
METTL8
methyltransferase like 8
chrX_-_134049233 0.09 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr6_-_150212029 0.09 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr19_+_50148087 0.09 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr12_-_53189892 0.09 ENST00000309505.3
ENST00000417996.2
KRT3
keratin 3
chr6_+_31126291 0.09 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr19_-_46288917 0.09 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr1_-_89488510 0.09 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr1_+_202317855 0.09 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr12_+_10460417 0.09 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr1_+_65613340 0.09 ENST00000546702.1
AK4
adenylate kinase 4
chr16_+_68877496 0.08 ENST00000261778.1
TANGO6
transport and golgi organization 6 homolog (Drosophila)
chr19_+_42746927 0.08 ENST00000378108.1
AC006486.1
AC006486.1
chr12_-_122711968 0.08 ENST00000485724.1
DIABLO
diablo, IAP-binding mitochondrial protein
chr1_-_33116128 0.08 ENST00000436661.1
ENST00000373501.2
ENST00000341885.5
ENST00000468695.1
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr1_+_65613217 0.08 ENST00000545314.1
AK4
adenylate kinase 4
chr12_+_12966250 0.08 ENST00000352940.4
ENST00000358007.3
ENST00000544400.1
DDX47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr6_-_111927062 0.08 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr11_+_118889142 0.08 ENST00000533632.1
TRAPPC4
trafficking protein particle complex 4
chr11_+_12399071 0.08 ENST00000539723.1
ENST00000550549.1
PARVA
parvin, alpha
chr20_-_31071309 0.08 ENST00000326071.4
C20orf112
chromosome 20 open reading frame 112
chr4_-_104021009 0.08 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr18_+_43684310 0.08 ENST00000592471.1
ENST00000585518.1
HAUS1
HAUS augmin-like complex, subunit 1
chr3_-_49058479 0.08 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr6_+_134273300 0.08 ENST00000416965.1
TBPL1
TBP-like 1
chr2_-_231989808 0.08 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr1_+_206317450 0.08 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr7_-_86849883 0.08 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr9_-_39239171 0.08 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr5_-_39270725 0.08 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr5_-_83680192 0.07 ENST00000380138.3
EDIL3
EGF-like repeats and discoidin I-like domains 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.1 0.3 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.1 0.7 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.3 GO:2000470 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.3 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0036101 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.2 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.1 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) regulation of tolerance induction dependent upon immune response(GO:0002652)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0006601 creatine biosynthetic process(GO:0006601)
0.0 0.1 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.1 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.3 GO:2000809 regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.1 GO:0039650 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:1902846 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.5 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.2 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
0.0 0.1 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.0 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.5 GO:0070822 Sin3-type complex(GO:0070822)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.3 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 0.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.2 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893) V2 vasopressin receptor binding(GO:0031896)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.0 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.2 GO:0034185 apolipoprotein binding(GO:0034185)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression