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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFKB2
Z-value: 1.33
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Transcription factors associated with NFKB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104155450_104155479 | 0.88 | 2.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 1.7 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 1.5 | GO:0007620 | copulation(GO:0007620) |
| 0.3 | 1.4 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.0 | 1.4 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 1.4 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.2 | 0.8 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.0 | 0.8 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.8 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 0.7 | GO:0000255 | allantoin metabolic process(GO:0000255) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.3 | 1.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.2 | 1.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 1.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.2 | 0.7 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.1 | 0.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 1.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 1.5 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 1.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 1.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.0 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.8 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.7 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.1 | 0.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.6 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 1.2 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.6 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.6 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 0.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |