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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFKB1
Z-value: 2.01
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103422471_103422495 | 0.95 | 4.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_74904398 Show fit | 6.19 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr2_+_228678550 Show fit | 5.15 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr4_-_74964904 Show fit | 3.97 |
ENST00000508487.2
|
chemokine (C-X-C motif) ligand 2 |
|
| chr2_+_113735575 Show fit | 3.67 |
ENST00000376489.2
ENST00000259205.4 |
interleukin 36, gamma |
|
| chr4_-_74864386 Show fit | 3.46 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr4_+_74735102 Show fit | 3.32 |
ENST00000395761.3
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
| chr6_+_138188551 Show fit | 3.09 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr5_-_150467221 Show fit | 3.08 |
ENST00000522226.1
|
TNFAIP3 interacting protein 1 |
|
| chr5_+_159895275 Show fit | 3.01 |
ENST00000517927.1
|
microRNA 146a |
|
| chr6_+_138188351 Show fit | 2.91 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.1 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.9 | 9.7 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 2.9 | 8.8 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 1.7 | 5.1 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.4 | 4.9 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.9 | 3.6 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.0 | 3.3 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.1 | 3.1 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.5 | 2.7 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.9 | 2.6 | GO:2000625 | regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 5.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.9 | 3.6 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 3.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.4 | 2.6 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 1.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 1.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 1.0 | GO:0097542 | ciliary tip(GO:0097542) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 18.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.5 | 9.8 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 9.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 1.7 | 5.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 3.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 3.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 3.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 2.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.3 | 1.9 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 1.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 19.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 3.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.7 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 23.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 15.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 4.1 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.1 | 3.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 2.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.3 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 1.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 1.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.0 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |