ISMARA results: NFIX

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFIX_NFIB

Z-value: 1.42

Motif logo

Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt NextProt	ENSG00000008441.12	nuclear factor I X
NFIB Ensembl NCBI GeneCards UniProt NextProt	ENSG00000147862.10	nuclear factor I B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIX	hg19_v2_chr19_+_13134772_13134846	0.74	9.5e-02	Click!
NFIB	hg19_v2_chr9_-_14322319_14322340	0.53	2.8e-01	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_41903161 Show fit	1.20	ENST00000602129.1 ENST00000593771.1 ENST00000596905.1 ENST00000221233.4	EXOSC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	exosome component 5
chr13_-_95364389 Show fit	0.77	ENST00000376945.2	SOX21 Ensembl NCBI GeneCards UniProt NextProt Show fit	SRY (sex determining region Y)-box 21
chr12_-_7077125 Show fit	0.76	ENST00000545555.2	PHB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	prohibitin 2
chr9_-_35658007 Show fit	0.74	ENST00000602361.1	RMRP Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA component of mitochondrial RNA processing endoribonuclease
chr19_+_36134528 Show fit	0.66	ENST00000591135.1	ETV2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ets variant 2
chr17_+_1633755 Show fit	0.61	ENST00000545662.1	WDR81 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 81
chr17_+_74729060 Show fit	0.57	ENST00000587459.1	RP11-318A15.7 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr22_-_51066521 Show fit	0.57	ENST00000395621.3 ENST00000395619.3 ENST00000356098.5 ENST00000216124.5 ENST00000453344.2 ENST00000547307.1 ENST00000547805.1	ARSA Ensembl NCBI GeneCards UniProt NextProt Show fit	arylsulfatase A
chr6_-_26108355 Show fit	0.56	ENST00000338379.4	HIST1H1T Ensembl NCBI GeneCards UniProt NextProt Show fit	histone cluster 1, H1t
chr17_-_79533608 Show fit	0.56	ENST00000572760.1 ENST00000573876.1	NPLOC4 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear protein localization 4 homolog (S. cerevisiae)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0018149	peptide cross-linking(GO:0018149)
0.2	1.2	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1	1.0	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	1.0	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1	0.9	GO:0006570	tyrosine metabolic process(GO:0006570)
0.1	0.9	GO:0006228	UTP biosynthetic process(GO:0006228)
0.1	0.8	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.8	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.7	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.7	GO:0031581	hemidesmosome assembly(GO:0031581)

Showing 1 to 10 of 541 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	1.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	1.2	GO:0001533	cornified envelope(GO:0001533)
0.0	1.0	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.9	GO:0045095	keratin filament(GO:0045095)
0.1	0.8	GO:0005638	lamin filament(GO:0005638)
0.0	0.8	GO:0000786	nucleosome(GO:0000786)
0.0	0.7	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.6	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.6	GO:0043034	costamere(GO:0043034)

Showing 1 to 10 of 132 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	GO:0003823	antigen binding(GO:0003823)
0.1	1.2	GO:0036122	BMP binding(GO:0036122)
0.0	1.2	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.0	1.0	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	1.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.3	0.8	GO:0004947	bradykinin receptor activity(GO:0004947)
0.0	0.8	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.8	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.7	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.7	GO:0005095	GTPase inhibitor activity(GO:0005095)

Showing 1 to 10 of 309 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.0	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.7	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.6	ST GAQ PATHWAY	G alpha q Pathway
0.0	0.5	PID MYC PATHWAY	C-MYC pathway
0.0	0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.1	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	1.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	1.1	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	1.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.8	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.7	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.6	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0	0.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.5	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway

Showing 1 to 10 of 38 entries

Results for NFIX_NFIB

Z-value: 1.42

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: