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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFATC2_NFATC3
Z-value: 1.45
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC3 | hg19_v2_chr16_+_68119764_68119868 | -0.87 | 2.6e-02 | Click! |
| NFATC2 | hg19_v2_chr20_-_50179368_50179392 | 0.31 | 5.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.6 | 1.8 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.0 | 1.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 1.1 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.3 | 1.0 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.0 | 1.0 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.2 | 0.9 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.1 | 0.9 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.0 | 0.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.8 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 1.3 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 0.9 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.7 | GO:0072536 | interleukin-23 receptor complex(GO:0072536) |
| 0.1 | 0.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 0.6 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 0.5 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.2 | 0.4 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.4 | 1.8 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 1.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 1.3 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.2 | 1.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 0.9 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 1.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.6 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |