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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFAT5
Z-value: 0.73
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Transcription factors associated with NFAT5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFAT5 | hg19_v2_chr16_+_69599861_69599887 | -0.77 | 7.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_103589789 Show fit | 0.55 |
ENST00000558056.1
ENST00000560869.1 |
tumor necrosis factor, alpha-induced protein 2 |
|
| chr6_+_138188351 Show fit | 0.51 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr14_+_95078714 Show fit | 0.49 |
ENST00000393078.3
ENST00000393080.4 ENST00000467132.1 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
|
| chr12_+_26274917 Show fit | 0.43 |
ENST00000538142.1
|
sarcospan |
|
| chr21_+_17792672 Show fit | 0.36 |
ENST00000602620.1
|
long intergenic non-protein coding RNA 478 |
|
| chr1_+_95975672 Show fit | 0.33 |
ENST00000440116.2
ENST00000456933.1 |
RP11-286B14.1 |
|
| chr4_+_105828492 Show fit | 0.31 |
ENST00000506148.1
|
RP11-556I14.1 |
|
| chr2_+_47799601 Show fit | 0.30 |
ENST00000601243.1
|
CDNA: FLJ23120 fis, clone LNG07989; HCG1987724; Uncharacterized protein |
|
| chr6_+_138188551 Show fit | 0.29 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr10_+_135122906 Show fit | 0.28 |
ENST00000368554.4
|
zinc finger protein 511 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFAT5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.0 | 0.8 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.3 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.0 | 0.3 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 0.2 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.1 | 0.2 | GO:0019364 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.1 | 0.2 | GO:0030264 | nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) |
| 0.0 | 0.2 | GO:0030309 | poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.0 | 0.2 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.4 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.3 | GO:0030914 | SAGA complex(GO:0000124) STAGA complex(GO:0030914) |
| 0.1 | 0.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.2 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 0.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.1 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 0.3 | GO:0031896 | vasopressin receptor binding(GO:0031893) V2 vasopressin receptor binding(GO:0031896) |
| 0.1 | 0.2 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.0 | 0.2 | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223) |
| 0.0 | 0.2 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.0 | 0.2 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.2 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.1 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.0 | 0.1 | GO:0043849 | Ras palmitoyltransferase activity(GO:0043849) |
| 0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |