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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MYBL2
Z-value: 1.49
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | -0.59 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.0 | 0.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.3 | 0.8 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.0 | 0.8 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.0 | 0.8 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.0 | 0.8 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.2 | 0.7 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.1 | 0.7 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.1 | 0.7 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.0 | 0.7 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 1.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 0.7 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.0 | 0.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 1.0 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.0 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.2 | 0.9 | GO:0033265 | choline binding(GO:0033265) |
| 0.0 | 0.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.7 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.6 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |